Abstract:
:The effect of endocannabinoids on synaptic plasticity has been demonstrated in a variety of species and brain regions. Relatively little is known about the localization and significance of cannabinoid (CB) receptors in the avian brain. The objective of the present study was to investigate the effect of a specific CB(1) receptor antagonist upon the acquisition and consolidation of memory in young domestic chicks. One-day-old domestic chicks (Gallus domesticus) were trained and tested by the passive avoidance paradigm. Systemic (i.p.) administration of the CB(1) receptor antagonist rimonabant in a dose of 1mg/kg 30 min before the training failed to affect learning, but a similar treatment 30 min before the recall (5.5h after training) attenuated the retention in 60% of animals. In another set of animals, a dose of 0.01 mg/kg produced no significant impairment, whereas doses 0.1mg/kg and 1.0mg/kg resulted in significant attenuation in passive avoidance performance when tested 30 min prior to recall. The results are discussed in terms of a putative mediating role of CB receptors in the consolidation of memory.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Adám AS,Wenger T,Csillag Adoi
10.1016/j.brainresbull.2008.02.004subject
Has Abstractpub_date
2008-06-15 00:00:00pages
272-4issue
3eissn
0361-9230issn
1873-2747pii
S0361-9230(08)00032-4journal_volume
76pub_type
杂志文章abstract::Prenatal cocaine exposure increases mu-opioid receptor binding in dopaminergic terminal areas and enhances behavioral responsiveness to mu-opioid agonists. We investigated the influence of early postnatal cocaine treatment on in vitro mu- and delta-opioid receptor activation in male and female weanling rats. Pups rece...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(00)00323-3
更新日期:2000-09-15 00:00:00
abstract::Microtubules are essential for the development and maintenance of axons and dendrites throughout the life of the neuron, and are vulnerable to degradation and disorganization in a variety of neurodegenerative diseases. Microtubules, polymers of tubulin heterodimers, are intrinsically polar structures with a plus end f...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2016.06.016
更新日期:2016-09-01 00:00:00
abstract::Cerebral ischemic damage in gerbils was assessed by locomotor activity studies and histopathological examination of the hippocampal CA1 pyramidal cell layer. Pretreatment with AICAr (50 and 500 mg/kg) 30 min prior to a 5-min ischemic episode in unanesthetized gerbils, significantly attenuated the degree of ischemic ne...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(90)90277-7
更新日期:1990-07-01 00:00:00
abstract::Waxing and waning electrographic responses (augmenting) and primary evoked responses could be induced in restricted regions of hippocampus, thalamus, and skeletal muscle by bipolar, low-frequency (7-10 Hz), low-amplitude (35 mV-4V) stimulation of selected sites within the hippocampus or thalamus of rabbits. Induction ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(77)90003-x
更新日期:1977-03-01 00:00:00
abstract::Neurobiotin and Lucifer yellow, indicators of gap junctional coupling, were applied to primary afferent fibers of the frog. Following application of tracers to cervical or lumbar dorsal root fibers, a large number of labeled granule cells were detected in the corpus cerebelli, the brainstem, and the spinal cord. The v...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00707-9
更新日期:2002-02-01 00:00:00
abstract::Groups of male Sprague-Dawley rats were predominantly fed either a high-fat or a high-carbohydrate (CHO) diet. For designated 2-day periods, their diets were switched. After baseline measurements of food and water intake, the rats were made diabetic by injections of either 40 or 46-50 mg/kg streptozotocin. Food and wa...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(86)90100-0
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:DTNBP1 gene variation and lower dysbindin-1 protein are associated with schizophrenia. Previous evidence suggests that downregulated dysbindin-1 expression results in lower expression of copper transporters ATP7A (intracellular copper transporter) and SLC31A1 (CTR1; extracellular copper transport...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.07.024
更新日期:2020-11-01 00:00:00
abstract::Studies were conducted to determine if norepinephrine activates both protein kinase C and the cyclic AMP-dependent protein kinase in cultured rat astrocytes using phosphoproteins as markers. Norepinephrine was found to decrease 32P incorporation into an acidic 80,000 M(R) protein. A similar response was observed with ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90059-7
更新日期:1992-09-01 00:00:00
abstract::The localization of CGRP mRNA in neurons of the rat brain and spinal cord was assessed by in situ hybridization histochemistry (ISH) using a radiolabeled synthetic 57-mer oligodeoxynucleotide probe complementary to the rat prepro CGRP mRNA. Results were compared with previously published findings of CGRP-immunoreactiv...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)00201-b
更新日期:1995-01-01 00:00:00
abstract::Recent findings in epigenetics shed new light on the regulation of gene expression in the central nervous system (CNS) during stress. The most frequently studied epigenetic mechanisms are DNA methylation, histone modifications and microRNA activity. These mechanisms stably determine cell phenotype but can also be resp...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2013.07.003
更新日期:2013-09-01 00:00:00
abstract::Delayed visual maturation (DVM) is characterised by visual unresponsiveness in early infancy, which subsequently improves spontaneously to normal levels. We studied the optokinetic response and recorded pattern reversal VEPs in six infants with DVM (aged 2-4 months) when they were at the stage of complete visual unres...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(96)00128-1
更新日期:1996-01-01 00:00:00
abstract::The volume and neuron number of the sexually dimorphic accessory olfactory bulb and locus coeruleus are altered by early postnatal exposure (from the day of birth to postnatal day 16) to diazepam. After diazepam treatment, both volume and neuron number were decreased in the male accessory olfactory bulb and in the fem...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90255-i
更新日期:1991-06-01 00:00:00
abstract::To assess the efficacy of using an HRP-coated wire knife to label cells of origin of cut axons, labeling cuts were made both through and parallel to the dorsal noradrenergic bundle. The damage to the dorsal bundle was evaluated independently by using fluorescence microscopy to detect the buildup of norepinephrine in c...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(82)90050-8
更新日期:1982-02-01 00:00:00
abstract::A method for bulk preparation of glomerular particles from subdivisions of the bovine cerebellum is presented. This method represents a modification of that previously reported by Hajos et al. [8], which increases the yield of glomerular protein by five-fold (5.5 mg/g wet wt) without compromising structural integrity ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(85)90025-5
更新日期:1985-05-01 00:00:00
abstract::Since the second decade of this century it has been known that opiates can influence ingestive behaviors. Generally, opioid agents enhance feeding and opioid antagonists decrease feeding. The present paper reviews the responsiveness of different animal species to opiates in relation to ingestive behaviors, the opioid ...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/0361-9230(85)90116-9
更新日期:1985-06-01 00:00:00
abstract::Fluoro-Ruby (tetramethylrhodamine-dextran amine conjugate) has been shown recently to be an effective anterograde tracer readily visible in brain sections with fluorescence microscopy. We show in this study that further microscopic analysis of Fluoro-Ruby-labeled elements is feasible with a conventional immunoperoxida...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90046-e
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:The effects of COX-2 inhibitors on seizure activity are controversial. The aim of the current study was to determine the post-treatment effect of aceclofenac on penicillin-induced experimental epilepsy. METHODS:Male Wistar rats were used in all experiments (n=18). The seizure activity was triggered by penicill...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2016.12.010
更新日期:2017-04-01 00:00:00
abstract::Chronic pain and depressive disorders have been estimated to co-occur in up to 80% of patients and traditional antidepressants and analgesics have shown limited clinical efficacy. α- (phenylselanyl) acetophenone (PSAP) is an organic selenium compound which has already demonstrated antioxidant, antidepressant and antin...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2018.07.007
更新日期:2018-09-01 00:00:00
abstract::The role of calmodulin (CaM) in organelle motility (fast axonal transport) in the axoplasm of the squid giant axon was evaluated directly using video-enhanced microscopy. Addition of 6 microM CaM to extruded squid axoplasm produced a 2.6-fold increase in the number of organelles moving per minute per unit area of axop...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)00256-8
更新日期:1995-01-01 00:00:00
abstract::After spinal cord injury (SCI) of the cat or rat neuronal centres below the level of lesion exhibit plasticity that can be exploited by specific training paradigms. In individuals with complete or incomplete SCI, human spinal locomotor centers can be activated by appropriate afferent input. This includes to facilitate...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/S0361-9230(08)00410-3
更新日期:2009-01-15 00:00:00
abstract:PURPOSE:We assessed the potential of resting-state fMRI lag analysis (RSLA) in detecting epileptic activation and in estimating anti-epileptic effects of Levetiracetam (LEV) in Rolandic epilepsy. METHODS:Forty-three children with Rolandic epilepsy underwent simultaneous EEG-fMRI. They were grouped into LEV vs drug-naï...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.05.016
更新日期:2020-09-01 00:00:00
abstract::Glutamate afferents reaching the ventral tegmental area (VTA) affect dopamine (DA) cells in this structure probably mainly via NMDA receptors. VTA appears to be one of the structures involved in regulation of hippocampal theta rhythm, and this work aimed at assessing the role of glutamatergic activation of the VTA in ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2014.06.001
更新日期:2014-08-01 00:00:00
abstract::Somatostatin immunoreactive (SOM-I) perikarya were first observed in the ventral horn at E12, in the presumptive intermediate gray area at E14, and in the alar plate of the rostral spinal cord at E14. In general, after their initial appearance, their density increased and then decreased during development. A moderate ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90125-6
更新日期:1988-07-01 00:00:00
abstract::Spontaneous locomotion and motor coordination was evaluated in young (5-6 month old) and aged (24-25 month old) rats. Animals were tested for spontaneous locomotor activity in Digiscan Animal Activity Monitors during the nocturnal cycle. Aged animals exhibited a significant hypoactivity compared to their young counter...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90294-l
更新日期:1993-01-01 00:00:00
abstract::Rats were unilaterally deprived of odor stimulation by surgically sealing one naris 1, 30 or 60 days after birth. Thirty days later the laminar volumes of the olfactory bulb ipsilateral to the occluded naris were compared with those ipsilateral to the normal side. Deprivation from days 1-30 resulted in approximately 2...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90121-1
更新日期:1983-11-01 00:00:00
abstract::Neonatal rats, when spinalized on the fourteenth postnatal day, showed minimal recovery of function in their hindlimbs. Bridging the cut spinal cord with E16 fetal spinal cord tissue did not improve functional recovery. Bridging, plus treatment with GM1 ganglioside, caused a significant (p less than 0.05) improvement ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90272-l
更新日期:1991-07-01 00:00:00
abstract::Schizophrenia (SZ) is a common and severe psychiatric disorder with both environmental and genetic risk factors, and a high heritability. After over 20 years of molecular genetics research, new molecular strategies, primarily genome-wide association studies (GWAS), have generated major tangible progress. This new data...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2010.04.009
更新日期:2010-09-30 00:00:00
abstract::Adenoviral vector directed gene transfer to rat facial motoneurons occurs efficiently following intra-parenchymal injection of relatively high dosages (> or =10(7) pfu per injection) of a prototype first generation adenoviral vector. However, high level of transgene expression, as observed during the first week follow...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(98)00042-2
更新日期:1998-09-15 00:00:00
abstract::Neutral, magnesium-stimulated sphingomyelinase and acid sphingomyelinase activities in the neurohypophysis, adenohypophysis and cerebrum of rats given 2.25% NaCl drinking water for 7 or 14 days were compared with the same enzyme activities in the tissues of control animals allowed free access to distilled drinking wat...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90028-x
更新日期:1983-05-01 00:00:00
abstract::Recent investigations of the nucleus ambiguus (NA) have attempted to identify motoneurons associated with the branchiomeric muscles of the larynx and pharynx. However, relatively little attention has been directed to the levator veli palatini muscle (LVP) which is critical in respiration, deglutition and eustachian tu...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90165-x
更新日期:1983-09-01 00:00:00