Early postnatal diazepam exposure alters sex differences in the rat brain.

Abstract:

:The volume and neuron number of the sexually dimorphic accessory olfactory bulb and locus coeruleus are altered by early postnatal exposure (from the day of birth to postnatal day 16) to diazepam. After diazepam treatment, both volume and neuron number were decreased in the male accessory olfactory bulb and in the female locus coeruleus. These results indicate that early postnatal diazepam administration can bear gender-dependent teratogenic effects upon sexually dimorphic nuclei and suggest that endogenous benzodiazepines may be involved in the sexual differentiation of the brain.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Segovia S,Pérez-Laso C,Rodríguez-Zafra M,Calés JM,Del Abril A,De Blas MR,Collado P,Valencia A,Guillamón A

doi

10.1016/0361-9230(91)90255-i

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

899-907

issue

6

eissn

0361-9230

issn

1873-2747

pii

0361-9230(91)90255-I

journal_volume

26

pub_type

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