Misexpression of miR-196a induces eye anomaly in Xenopus laevis.


:miR-196a is located in the posterior trunk and plays a role in limb development. Here we show that miR-196a is able to induce eye anomaly in Xenopus laevis. Microinjection of synthetic miRNA precursor molecule for mammalian miR-196a into Xenopus embryo is sufficient for miR-196a overexpression during early development. The misexpression of miR-196a in anterior embryo led to dose-dependent eye anomalies, especially size reduction. In addition, the expression of ET, Rx1, Six3, Pax6, Lhx2, Optx2 and Ath5 in eye field or optic cup was also down-regulated. These results indicate that miR-196a can target gene(s) in the genetic network involved in eye formation, providing a potential tool for studying the mechanisms of eye development and diseases.


Brain Res Bull


Brain research bulletin


Qiu R,Liu Y,Wu JY,Liu K,Mo W,He R




Has Abstract


2009-04-06 00:00:00














  • Hypophagic and dipsogenic effects of central 5-HT injections in pigeons.

    abstract::The present work describes a series of experiments designed to examine the possible role of central 5-HT circuits in the control of feeding and drinking in pigeons. Acute effects (within 1 h) of intracerebroventricular (ICV) injections of 5-HT (0, 9.7, 19.4, 38.7, 77.5, 155, and 310 nmol) in 24-h food-deprived (24FD) ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Steffens SM,Casas DC,Milanez BC,Freitas CG,Paschoalini MA,Marino-Neto J

    更新日期:1997-01-01 00:00:00

  • Enhancement of electroacupuncture-induced analgesic effect in cholecystokinin-A receptor deficient rats.

    abstract::Previously, we have showed that the cholecystokinin (CCK)-A receptor expression in hypothalamus is closely related with the responsiveness of electroacupuncture (EA)-mediated analgesic effects in rats. In order to confirm this observation more directly in vivo, the EA-mediated analgesic effects are compared between Ot...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Lee GS,Han JB,Shin MK,Hong MC,Kim SW,Min BI,Bae H

    更新日期:2003-12-15 00:00:00

  • Depressed excitability and integrated EEGs following hippocampal afterdischarges.

    abstract::Rats with chronic hippocampal electrode implants had afterdischarges induced with electrical stimulus intensities of 115, 200, and 800% of a previously determined threshold. Afterdischarge duration, postictal EEG depression duration, and the duration of postictal electrical hypoexcitability were assessed. After discha...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Swartzwelder HS,Wegener ST,Johnson CT,Dyer RS

    更新日期:1980-09-01 00:00:00

  • Butyrate alleviates PTZ-induced mitochondrial dysfunction, oxidative stress and neuron apoptosis in mice via Keap1/Nrf2/HO-1 pathway.

    abstract::This study aims to evaluate the neuroprotective effect of sodium butyrate against the pentylenetetrazol (PTZ)-induced kindling epilepsy. Sodium butyrate (SB) (5, 10 and 20 mg/kg) and sodium valproate for 40 days and PTZ (37 mg/kg) injection every day were conducted for Kunming mice, to investigate seizure intensity an...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Li D,Bai X,Jiang Y,Cheng Y

    更新日期:2020-12-28 00:00:00

  • The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.

    abstract::Intra-arterial administration of papaverine has been revealed to cause an increase in the blood-brain tumor barrier (BTB) permeability. The exact mechanism of papaverine opening the BTB in chemotherapy of malignant cerebral tumors, however, has not been well described. We used a rat brain glioma (C6) model for studyin...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Wang ZH,Xue YX,Liu YH

    更新日期:2010-11-20 00:00:00

  • Intracellularly studied excitability changes in coronal-pericruciate neurons following low frequency stimulation of the corticobulbar tract.

    abstract::Direct intracellular measurements of excitability changes to injected current were made in 116 cortical neurons of awake cats following antidromic or orthodromic activation by repetitive, 1-6 Hz stimulation of the pes pedunculi. The predominant effect seen in antidromically activated cells was a transient decrease in ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Tzebelikos E,Woody CD

    更新日期:1979-09-01 00:00:00

  • Neuroprotective role of alendronate against APP processing and neuroinflammation in mice fed a high fat diet.

    abstract::Obesity and consumption of diet rich in fat are known to contribute to the development of Alzheimer's disease (AD) which is a complex and multifactorial neurodegenerative disease and a leading cause of mortality with unmet medical needs. Hypercholesterolemia was discovered to increase neuropathological changes along w...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Zameer S,Alam M,Hussain S,Vohora D,Ali J,Najmi AK,Akhtar M

    更新日期:2020-08-01 00:00:00

  • A driving simulation task: correlations with Multiple Sleep Latency Test.

    abstract::Sleepiness and driving is a dangerous combination that causes thousands of crashes each year resulting in injury and death. In the last few years, driving simulators have been used to study the performance decrements associated with drowsiness. We correlated performances of a driving simulation task in healthy volunte...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Pizza F,Contardi S,Mostacci B,Mondini S,Cirignotta F

    更新日期:2004-06-30 00:00:00

  • Regulation by equilibrative nucleoside transporter of adenosine outward currents in adult rat spinal dorsal horn neurons.

    abstract::A current response induced by superfusing adenosine was examined in substantia gelatinosa (SG) neurons of adult rat spinal cord slices by using the whole-cell patch-clamp technique. In 78% of the neurons examined, adenosine induced an outward current at -70 mV [18.8 +/- 1.1 pA (n = 98) at 1mM] in a dose-dependent mann...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Liu T,Fujita T,Kawasaki Y,Kumamoto E

    更新日期:2004-07-30 00:00:00

  • The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function.

    abstract::Locomotor performance of transgenic R6/2 mice carrying the Huntington's disease (HD) mutation was assessed using four different tasks, fixed speed rotarod, accelerating rotarod, Digigait and footprint test. The tasks were compared directly in age- and CAG repeat-matched R6/2 mice. Accelerating rotarod was more sensiti...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Pallier PN,Drew CJ,Morton AJ

    更新日期:2009-03-30 00:00:00

  • Sex differences in interhemispheric correlation and spectral power of EEG activity.

    abstract::EEG activity was recorded from left and right parietal cortex in adult male and female rats on a daily basis during 3 days. Absolute and relative power and interhemispheric correlation of the EEG activity were calculated and compared between males and females. Interhemispheric correlation of the theta rhythm was highe...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Juárez J,Corsi-Cabrera M

    更新日期:1995-01-01 00:00:00

  • Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life.

    abstract::Bacillus Calmette-Guérin (BCG) is administered to neonates worldwide, but it is still unknown whether this neonatal vaccination affects brain development during early postnatal life, despite the close association of the immune system with the brain. Newborn C57BL/6 mice were injected subcutaneously with BCG or phospha...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Yang J,Qi F,Gu H,Zou J,Yang Y,Yuan Q,Yao Z

    更新日期:2016-01-01 00:00:00

  • FGF9 knockout in GABAergic neurons induces apoptosis and inflammation via the Fas/caspase-3 pathway in the cerebellum of mice.

    abstract::Fibroblast growth factor 9 (FGF9) is a member of the fibroblast growth factor family and is widely expressed in the central nervous system (CNS). However, it is not clear how the working mechanism of FGF9 is involved in cerebellar development. To address this question, we deleted the Fgf9 gene specifically in GABAergi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Guo M,Chen H,Duan W,Li Z,Li Y,Ma Y,Xu X,Yi L,Bi Y,Liu Y,Zhang J,Li C

    更新日期:2020-01-01 00:00:00

  • Transport of fatty acids and monoacylglycerols in white and brown adipose tissues.

    abstract::Long chain fatty acids (FA) and 2-monoacylglycerols (MG) are produced by lipoprotein lipase (LPL) from plasma triacylglycerols (TG) in capillaries of adipose tissue and transported to adipocytes for TG synthesis. It is widely proposed FA may be transported in cells by FA-binding protein. Mode of transport of MG has re...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Scow RO,Blanchette-Mackie EJ

    更新日期:1991-09-01 00:00:00

  • Periaqueductal gray neurons response to microiontophoretically injected morphine in naive and morphine-dependent rats.

    abstract::The attempt of this study was to investigate the direct effects of increasing doses of morphine on the neuronal activity of the periaqueductal gray in morphine-naive and morphine-dependent rats. The microiontophoresis technique was used for this purpose. The four different responses induced by morphine exhibited dose-...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Schurr A,Rigor BM,Ho BT,Dafny N

    更新日期:1981-06-01 00:00:00

  • Blockade of stress-induced prolactin release in monosodium glutamate-treated rats.

    abstract::To elucidate the role of the medial basal hypothalamus (MBH) in stress-induced prolactin (Prl) release, adult male rats which had received monosodium glutamate (MSG 4 mg/g) on alternate days for the first 10 days of life were subjected to ether stress for 2 min. Blood samples were drawn at 0, 15, 30 and 60 min after e...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Mizunuma H,Khorram O,McCann SM

    更新日期:1983-01-01 00:00:00

  • Zinc-bound metallothioneins as potential biological markers of ageing.

    abstract::Metallothioneins (MTs) (I+II) play pivotal roles in metal-related cell homeostasis because of their high affinity for metals forming clusters. The main functional role of MTs is to sequester and/or dispense zinc participating in zinc homeostasis. Consistent with this role, MT gene expression is transcriptionally induc...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Mocchegiani E,Giacconi R,Cipriano C,Muzzioli M,Fattoretti P,Bertoni-Freddari C,Isani G,Zambenedetti P,Zatta P

    更新日期:2001-05-15 00:00:00

  • Neuroautoantibody immunoreactivity in relation to aging and stress in apolipoprotein E-deficient mice.

    abstract::Progressive disruption of both the neuroendocrine and immune systems has been correlated with age-associated pathogenesis in patients with Alzheimer's disease and in mice lacking apolipoprotein E (ApoE). In this study, we examined neuroautoimmune and neuroendocrine activities in relation to aging and stress in ApoE-de...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Zhou Y,Cheshire A,Howell LA,Ryan DH,Harris RB

    更新日期:1999-06-01 00:00:00

  • Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance.

    abstract::Rats were tested in the elevated plus-maze test of anxiety after a probe injection of chlordiazepoxide (CDP 5 mg/kg) following short-term (5 days) or long-term (20 days) pretreatment with 5 or 20 mg/kg/day. After short-term pretreatment with either dose, the probe dose had anxiolytic effects (it increased the % number...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: File SE,Baldwin HA,Aranko K

    更新日期:1987-11-01 00:00:00

  • Ultrastructure of HRP-labelled neurons: a comparison of two sensitive techniques.

    abstract::Rat sciatic nerves were transected and placed in a solution of HRP. Following perfusion, L4-6 spinal segments and sensory ganglia were cut into 60 micron sections. Alternate sections were processed with the glucose oxidase (GOD) or the benzidine dihydrochloride (BDHC) procedure. Sections were then either mounted on gl...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Mawe GM,Bresnahan JC,Beattie MS

    更新日期:1983-04-01 00:00:00

  • Persistent alterations in GABAA receptor binding and function after prenatal lorazepam administration in the chick.

    abstract::Behavioral abnormalities have been reported in young and adult animals exposed to benzodiazepines prenatally. The presence of neurochemical alterations in the GABAergic system after prenatal benzodiazepine exposure was assessed in a chick model which avoids prenatal and postnatal maternal effects. The GABAA receptor c...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Miller LG,Roy RB,Weill CL,Lopez F

    更新日期:1989-09-01 00:00:00

  • Sadness as a passion of the soul: a psychopathological consideration of the Cartesian concept of melancholy.

    abstract::The relationship between the "passions" (emotions or feelings) and psychopathology has been a constant throughout the history of medicine. In this context, melancholy was considered a perversion of the soul (corruption of the passions). One of the most influential authors on this subject was René Descartes, who discus...

    journal_title:Brain research bulletin

    pub_type: 历史文章,杂志文章,评审


    authors: López-Muñoz F,Rubio G,Molina JD,Alamo C

    更新日期:2011-04-25 00:00:00

  • Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier.

    abstract::Although iron is involved in brain function, very little is known about the regulation of its concentrations in the central nervous system. We quantitatively measured the entry and exit rates of iron, transferrin (its major transport protein), and albumin in mice. The blood to brain transport of iron greater than tran...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Banks WA,Kastin AJ,Fasold MB,Barrera CM,Augereau G

    更新日期:1988-12-01 00:00:00

  • Endocytosis of horseradish peroxidase by brain microvascular and umbilical vein endothelial cells in culture: an ultrastructural and morphometric study.

    abstract::The ability to form tight junctions and the paucity of fluid phase endocytosis showed by brain microvacular endothelial cells (BMECs) make up the structural basis of the blood-brain barrier (BBB). Most studies on cultured BMECs focused on intercellular junctions, whereas endocytosis received lesser attention. We studi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Defazio G,Ribatti D,Nico B,Ricchiuti F,De Salvia R,Roncali L,Livrea P

    更新日期:1997-01-01 00:00:00

  • Triplet repeats, over-expanded in neuromuscular diseases, are under-represented in mammalian DNA: a survey of models.

    abstract::Simple tandem repeats represent more than 1% of the human genome: occasionally they exhibit intergenerational expansibility and are associated with neuromuscular diseases. In transgenic mice the same sequences elicit similar symptoms, but do not expand. We have searched for di-, tri-, and tetra-repeats in the publishe...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Astolfi P,Bellizzi D,Losso MA,Sgaramella V

    更新日期:2001-10-01 00:00:00

  • Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact.

    abstract::Epigenetic processes are involved in regulation of cell functions and survival, but their role in responses of neurons and glial cells to oxidative injury is insufficiently explored. Here, we studied the role of DNA methylation and histone deacetylation in reactions of neurons and surrounding glial cells to photodynam...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Sharifulina SA,Komandirov MA,Uzdensky AB

    更新日期:2014-03-01 00:00:00

  • Evaluation of muscle re-innervation employing pre- and post-axotomy injections of fluorescent retrograde tracers.

    abstract::In experimental studies on peripheral nerve repair, the possibility to objectively compare original and post-operative innervation is of decisive importance for the selection of the proper nerve-reconstruction strategy. Herewith we report serious drawbacks encountered with the standard method of pre- and post-operativ...

    journal_title:Brain research bulletin



    authors: Popratiloff AS,Neiss WF,Skouras E,Streppel M,Guntinas-Lichius O,Angelov DN

    更新日期:2001-01-01 00:00:00

  • Brain habituation during repeated exposure to fearful and neutral faces: a functional MRI study.

    abstract::Central nervous system habituation in humans was studied using functional magnetic resonance imaging and repeated presentations of single fearful and neutral faces. Habituation of blood-oxygenation-level-dependent (BOLD) signal during exposure to face stimuli, collapsed over fearful and neutral expressions, was eviden...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Fischer H,Wright CI,Whalen PJ,McInerney SC,Shin LM,Rauch SL

    更新日期:2003-01-30 00:00:00

  • Sex differences and estrous cycle-variations in the AF64A-induced cholinergic deficit in the rat hippocampus.

    abstract::The influence of gender and stage of the estrous cycle on the levels of acetylcholine, serotonin, and noradrenaline in the hippocampus and on the susceptibility of the cholinergic septo-hippocampal pathway to the neurotoxic effect of ethylcholine aziridinium (AF64A) was investigated in the rat. Levels of acetylcholine...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Hörtnagl H,Hansen L,Kindel G,Schneider B,el Tamer A,Hanin I

    更新日期:1993-01-01 00:00:00

  • The use of place conditioning in studying the neuropharmacology of drug reinforcement.

    abstract::The place conditioning paradigm has proven successful in identifying the neural mechanisms of drug reinforcement. Two classes of drugs, opiates and psychomotor stimulants, have received the most study, and in each case an important role for DA neurons of the mesolimbic system has been established. Moreover, both recep...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Hoffman DC

    更新日期:1989-10-01 00:00:00