Abstract：
PURPOSE:We assessed the potential of resting-state fMRI lag analysis (RSLA) in detecting epileptic activation and in estimating anti-epileptic effects of Levetiracetam (LEV) in Rolandic epilepsy. METHODS:Forty-three children with Rolandic epilepsy underwent simultaneous EEG-fMRI. They were grouped into LEV vs drug-naïve groups according to their medication, and into patients who showed or did not show central-temporal spike (CTS) discharges during scans. We calculated the lag structure of rs-fMRI for all patients and assessed interactions with drug (LEV vs. drug-naïve) and CTS status (CTS vs. no-CTS). We furthermore assessed correlations between lag values and number of CTS and medication conditions. RESULTS:RSLA analysis indicated earlier intrinsic activations in bilateral Rolandic areas when CTS occurred. More frequent epileptic discharges were correlated with earlier intrinsic activations (r=-0.46, p = 0.03 left Rolandic). Patients with LEV therapy, on the other hand, displayed delayed intrinsic activity in Rolandic areas compared to drug-naïve patients CONCLUSION: Our RSLA analysis indicated an association between centro-temporal spikes and earlier hemodynamic activations in epileptogenic regions in Rolandic epilepsy, which were counteracted by LEV treatment. As it allows for the mapping of propagation features of intrinsic activity and drug-effects, our findings suggest potential of lag based analyses in detecting focus localization and estimating treatment effects.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Xu Q,Hu Z,Yang F,Bernhardt BC,Zhang Q,Stufflebeaskm SM,Zhang Z,Lu Gdoi
10.1016/j.brainresbull.2020.05.016subject
Has Abstractpub_date
2020-09-01 00:00:00pages
125-131eissn
0361-9230issn
1873-2747pii
S0361-9230(20)30512-8journal_volume
162pub_type
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pub_type： 杂志文章,评审
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journal_title：Brain research bulletin
pub_type： 传,历史文章,杂志文章
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