Intrahippocampal grafts of cholinergic-rich striatal tissue ameliorate spatial memory deficits in rats with fornix lesions.

abstract：:Baroreceptor input plays a critical role in body fluid balance and the endocrine response to NaCl consumption [25]. Experiments were performed to characterize the alterations in salt intake that are seen after baroreceptor denervation. Using chronically baroreceptor denervated (SAD) or control (CON) male Sprague-Dawle...

journal_title：Brain research bulletin

authors： Rocha MJ,Callahan MF,Morris M

更新日期：1997-01-01 00:00:00

abstract：:The neuropathology of Alzheimer disease is characterized by senile plaques, neurofibrillary tangles and cell death. These hallmarks develop according to the differential vulnerability of brain networks, senile plaques accumulating preferentially in the associative cortical areas and neurofibrillary tangles in the ento...

journal_title：Brain research bulletin

authors： Savioz A,Leuba G,Vallet PG,Walzer C

更新日期：2009-10-28 00:00:00

abstract：:The biochemical balance between right- and left-ascending DA systems is an essential factor to regulate behavioral lateralization. However, there is no electrophysiological evidence for the regulation of interhemispheric DA systems. In the present paper we report electrophysiological evidence supporting the hypothesis...

journal_title：Brain research bulletin

authors： Castellano MA,Rodriguez Diaz M

更新日期：1991-08-01 00:00:00

abstract：:The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to...

journal_title：Brain research bulletin

authors： Wilkins HM,Swerdlow RH

更新日期：2017-07-01 00:00:00

abstract：:This study analyzed the projection neurons of the anterior subdivision of the rat basolateral amygdaloid nucleus (BLa) by correlating the morphology of Golgi-stained neurons with the morphology of neurons that were retrogradely labeled by injections into the main terminal fields of BLa. In each animal multiple injecti...

journal_title：Brain research bulletin

authors： McDonald AJ

更新日期：1992-02-01 00:00:00

abstract：:We investigated the effects of mild hyperglycemia and insulin treatment on the metabolism of the ischemic brain in spontaneously hypertensive rats with acute hyperglycemia (n = 9), acute hyperglycemia treated with insulin during ischemia (n = 10), and normoglycemia (n = 10). Cerebral blood flow was measured by the H2 ...

journal_title：Brain research bulletin

authors： Sugimori H,Ibayashi S,Fujii K,Nagao T,Sadoshima S,Fujishima M

更新日期：1996-01-01 00:00:00

abstract：:Adult male Sprague-Dawley rats were made paraplegic by a complete transection of the spinal cord at lower thoracic level. One week later they were transplanted, below the level of the section, with a cell suspension prepared from the raphe region of 14-day embryos. After survival periods of 10 days to 1 year, the anim...

journal_title：Brain research bulletin

authors： Privat A,Mansour H,Rajaofetra N,Geffard M

更新日期：1989-01-01 00:00:00

abstract：:Subpallial structures are highly conserved across the different vertebrate species. They are instrumental in the neural processing relevant to adaptive learning, decision making, motivation and behavioural strategies. Of the striatal regions, our attention has been focussed on the medial and ventral striatum (MSt), no...

journal_title：Brain research bulletin

authors： Csillag A,Bálint E,Adám A,Zachar G

更新日期：2008-06-15 00:00:00

abstract：:Using immunohistochemistry for serotonin (5-HT) after administration of 5-hydroxytryptophan (5-HTP), we have demonstrated the existence of a particular group of 5-HT accumulating neurons in the posterior hypothalamus of the rat and cat. This cluster of neurons, which we termed "5-HT immunoreactive (IR) posterior hypot...

journal_title：Brain research bulletin

authors： Sakumoto T,Sakai K,Jouvet M,Kimura H,Maeda T

更新日期：1984-06-01 00:00:00

abstract：:Isoflurane (ISO) is an anesthesia and can result in neuron injury. A previous study has indicated that microRNA-302b-3p (miR-302b-3p) exerts a crucial function in modulating cerebral ischemia/reperfusion damage-induced neuronal injury. We sought to examine the role of miR-302b-3p in ISO-induced neuronal injury. In the...

journal_title：Brain research bulletin

authors： Li L,Lu S,Fan X

更新日期：2020-12-25 00:00:00

abstract：:Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain. However, insulin receptors are important for brain function...

journal_title：Brain research bulletin

authors： Mueller PL,Pritchett CE,Wiechman TN,Zharikov A,Hajnal A

更新日期：2018-10-01 00:00:00

abstract：:Impairment of endosomal/lysosomal functions are reported as some of the earliest changes in several age-related neurological disorders such as Alzheimer's disease. Dysregulation of the lysosomal system is also accompanied by the accumulation of age-associated pigments and several recent reports have indicated that thi...

journal_title：Brain research bulletin

authors： Ditaranto-Desimone K,Saito M,Tekirian TL,Saito M,Berg M,Dubowchik G,Soreghan B,Thomas S,Marks N,Yang AJ

更新日期：2003-02-15 00:00:00

abstract：:The effects of post-training intra-hippocampal injections of group I mGluR agonists and antagonists, were examined in the contextual fear test, in rats. It was found that (S)-3,5-dihydroxyphenylglycine (DHPG) (a mGluR1-5 agonist) decreased, and (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) (a mGluR1 antagonist) incre...

journal_title：Brain research bulletin

authors： Maciejak P,Taracha E,Lehner M,Szyndler J,Bidziński A,Skórzewska A,Wisłowska A,Zienowicz M,Płaźnik A

更新日期：2003-11-15 00:00:00

abstract：:A reduction in nerve conduction velocity and an increase in resistance to ischemic conduction failure are early signs of neural dysfunction in both diabetic patients and animal models of diabetes. The effect of Bimoclomol (BRLP-42), a drug under clinical development for the treatment of diabetic complications, on expe...

journal_title：Brain research bulletin

authors： Bíró K,Jednákovits A,Kukorelli T,Hegedüs E,Korányi L

更新日期：1997-01-01 00:00:00

abstract：:The effects of administration of isoproterenol, a beta-adrenergic agonist, and angiotensin II, a peptide, separately and in combination, on water intake and blood pressure of rats were studied. The results of 6 factorially designed studies in which 4 different doses of each compound were administered revealed that wat...

journal_title：Brain research bulletin

authors： Fregly MJ,Threatte RM,Barney CC,Katovich MJ

更新日期：1983-03-01 00:00:00

abstract：:A newly developed technique employing the retrograde transport of horseradish peroxidase combined with immunocytochemistry is used to identify the cells of origin of descending spinal pathways and their putative neurotransmitters. With this technique the brainstem origins of descending serotonergic (5HT) pathways to t...

journal_title：Brain research bulletin

authors： Bowker RM,Westlund KN,Coulter JD

更新日期：1982-07-01 00:00:00

abstract：:The efferent and centrifugal afferent connections of the main olfactory bulb (MOB) of the mouse were studied by orthograde and retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP). MOB projects ipsilaterally to the anterior olfactory nucleus, taenia tecta, anterior hippocampal c...

journal_title：Brain research bulletin

authors： Shipley MT,Adamek GD

更新日期：1984-06-01 00:00:00

abstract：:The ability to form tight junctions and the paucity of fluid phase endocytosis showed by brain microvacular endothelial cells (BMECs) make up the structural basis of the blood-brain barrier (BBB). Most studies on cultured BMECs focused on intercellular junctions, whereas endocytosis received lesser attention. We studi...

journal_title：Brain research bulletin

authors： Defazio G,Ribatti D,Nico B,Ricchiuti F,De Salvia R,Roncali L,Livrea P

更新日期：1997-01-01 00:00:00

abstract：:Groups of male Sprague-Dawley rats were predominantly fed either a high-fat or a high-carbohydrate (CHO) diet. For designated 2-day periods, their diets were switched. After baseline measurements of food and water intake, the rats were made diabetic by injections of either 40 or 46-50 mg/kg streptozotocin. Food and wa...

journal_title：Brain research bulletin

authors： Koopmans HS,Xavier Pi-Sunyer F

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In humans, activation of the diving reflex by a cold stimulus to the face results in bradycardia, peripheral vasoconstriction and an increase in blood pressure. However, responses of the cerebral blood flow have not yet been evaluated. We undertook this study to assess the effect of cold face sti...

journal_title：Brain research bulletin

authors： Brown CM,Sanya EO,Hilz MJ

更新日期：2003-06-30 00:00:00

abstract：:The aim of this study was to investigate whether the histamine H1-receptor blocker, chlorpheniramine (CPA), has a reinforcing effect in goldfish. We used a place-preference procedure in an aquarium with two chambers colored black and white. On day 1, the animals were placed in the test chamber for 10 min for habituati...

journal_title：Brain research bulletin

authors： Mattioli R,Nelson CA,Huston JP,Spieler RE

更新日期：1998-01-01 00:00:00

abstract：:Depression is the root of various diseases. It is one of the most debilitating conditions globally. Antidepressant drugs are usually the first-line of depression treatment. Arctigenin (ARC), one of active ingredient of Arctium lappa L, has been found to exert neuroprotective, anti-decrepitude, and anti-inflammatory ac...

journal_title：Brain research bulletin

authors： Du Y,Li W,Li Y,Yang J,Wang X,Yin S,Wang X,Velez de-la-Paz OI,Gao Y,Chen H,Yin X,Shi H

更新日期：2019-03-01 00:00:00

abstract：:The gonadotropin-releasing hormone-associated peptide (GAP) and luteinizing hormone-releasing hormone (LHRH) portions of the LHRH precursor were localized by immunocytochemistry in prepubertal female rats, in adult female rats at different stages of the estrous cycle, and in ovariectomized rats. Our results indicate t...

journal_title：Brain research bulletin

authors： Merchenthaler I,Culler MD,Negro-Vilar A,Petrusz P,Flerko B

更新日期：1988-06-01 00:00:00

abstract：:Systemically administered human recombinant erythropoietin (EPO) may have the potential to reduce the cognitive and behavioural symptoms of mechanical brain injury. In a series of studies we address this possibility. Previously, we studied the effects of EPO given to fimbria-fornix transected rats at the moment of inj...

journal_title：Brain research bulletin

authors： Mogensen J,Boyd MH,Nielsen MD,Kristensen RS,Malá H

更新日期：2008-09-05 00:00:00

abstract：:Insulin release was examined in human subjects after lingual applications of D-glucose and its anomers. A dose-dependent increase in the insulin release was noted following the application of equilibrated D-glucose consisting of 36% alpha- and 64% beta-anomer. The response was not reproduced after administration of at...

journal_title：Brain research bulletin

authors： Yamazaki M,Sakaguchi T

更新日期：1986-08-01 00:00:00

abstract：:Three models of inducing spinal trauma in experimental animals--weight-dropping model, severance-by-knife model, and laceration-type-lesions model--are reviewed critically. Contributions by these models in understanding paraplegia in anatomical and pathological terms are brought out. Important distinctions between sub...

journal_title：Brain research bulletin

authors： Das GD

更新日期：1989-01-01 00:00:00

abstract：:Endocannabinoid system activity contributes to the homeostatic defense against aging and thus may counteract the progression of brain aging. The cannabinoid type 1 (CB1) receptor activity declines with aging in the brain, which impairs neuronal network integrity and cognitive functions. However, the underlying mechani...

journal_title：Brain research bulletin

authors： Kataoka K,Bilkei-Gorzo A,Nozaki C,Togo A,Nakamura K,Ohta K,Zimmer A,Asahi T

更新日期：2020-07-01 00:00:00

abstract：:Studies were conducted to determine if norepinephrine activates both protein kinase C and the cyclic AMP-dependent protein kinase in cultured rat astrocytes using phosphoproteins as markers. Norepinephrine was found to decrease 32P incorporation into an acidic 80,000 M(R) protein. A similar response was observed with ...

journal_title：Brain research bulletin

authors： Mobley PL,Combs DL

更新日期：1992-09-01 00:00:00

abstract：:Ten years after the discovery of human diseases caused by trinucleotide repeat expansions, searching for mechanistic links between gene mutation and pathological phenotype remains a fundamental and unsolved issue. Evidence accumulated so far indicates that the pathogenesis of repeat disorders is complex and multi-fact...

journal_title：Brain research bulletin

authors： Galvão R,Mendes-Soares L,Câmara J,Jaco I,Carmo-Fonseca M

更新日期：2001-10-01 00:00:00

abstract：:Parkinson's disease (PD) is mostly known as a dopamine deficiency syndrome due the structural and functional changes in striatal projection neurons. However, studies have considered this pathology as a multi-systemic disease in which the neurodegenerative process extends beyond the dopaminergic system. Therefore, the ...

journal_title：Brain research bulletin

authors： Leal PC,Bispo JMM,Lins LCRF,Souza MF,Gois AM,Moore C,Marchioro M,Ribeiro AM,Silva RH,Meshul CK,Santos JR

更新日期：2019-03-01 00:00:00