Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats.

abstract：:Parkinson's disease (PD) is mostly known as a dopamine deficiency syndrome due the structural and functional changes in striatal projection neurons. However, studies have considered this pathology as a multi-systemic disease in which the neurodegenerative process extends beyond the dopaminergic system. Therefore, the ...

journal_title：Brain research bulletin

authors： Leal PC,Bispo JMM,Lins LCRF,Souza MF,Gois AM,Moore C,Marchioro M,Ribeiro AM,Silva RH,Meshul CK,Santos JR

更新日期：2019-03-01 00:00:00

abstract：:Every year, a large number of infants and young children worldwide are administered general anesthesia. Whether general anesthesia adversely affects the intellectual development and cognitive function of children at a later date remains controversial. Many animal experiments have shown that general anesthetics can cau...

journal_title：Brain research bulletin

authors： Yang F,Zhao H,Zhang K,Wu X,Liu H

更新日期：2020-11-01 00:00:00

abstract：:A newly developed technique employing the retrograde transport of horseradish peroxidase combined with immunocytochemistry is used to identify the cells of origin of descending spinal pathways and their putative neurotransmitters. With this technique the brainstem origins of descending serotonergic (5HT) pathways to t...

journal_title：Brain research bulletin

authors： Bowker RM,Westlund KN,Coulter JD

更新日期：1982-07-01 00:00:00

abstract：:Klotho, which is a life extension factor, and erythropoietin (EPO) have been introduced as effective neuroprotective factors in several neurological disorders. The present study is an attempt to examine the potential role of klotho and EPO in therapeutic effect of curcumin-loaded nanoparticles (NPs) in pentylenetetraz...

journal_title：Brain research bulletin

authors： Mansoor SR,Hashemian M,Khalili-Fomeshi M,Ashrafpour M,Moghadamnia AA,Ghasemi-Kasman M

更新日期：2018-09-01 00:00:00

abstract：:Gonadal hormones exert a critical influence over the architecture of specific brain areas affecting the formation of neuronal contacts. Cellular mechanisms mediating gonadal hormone actions on synapses have been studied extensively in the rat arcuate nucleus, a hypothalamic center involved in the feed-back regulation ...

journal_title：Brain research bulletin

authors： Fernandez-Galaz MC,Morschl E,Chowen JA,Torres-Aleman I,Naftolin F,Garcia-Segura LM

更新日期：1997-01-01 00:00:00

abstract：:Microspectrofluorometry has played an important part in the development and understanding of fluorescence techniques for the demonstration of biogenic amines. This paper reviews briefly the techniques currently available for the characterization and localization of biogenic amines, and considers the basic design consi...

journal_title：Brain research bulletin

authors： Wreford NG,Smith GC

更新日期：1982-07-01 00:00:00

abstract：:Patients with post-traumatic stress disorder (PTSD) tend to misinterpret innocuous stimuli as potential threats, possibly due to a conditioning provoked by traumatic episodes. Previous neuroimaging evidence has shown an abnormal activation of the amygdala and prefrontal cortex in PTSD patients during fear conditioning...

journal_title：Brain research bulletin

authors： Brunetti M,Sepede G,Ferretti A,Mingoia G,Romani GL,Babiloni C

更新日期：2015-05-01 00:00:00

abstract：:EEG activity was recorded from left and right parietal cortex in adult male and female rats on a daily basis during 3 days. Absolute and relative power and interhemispheric correlation of the EEG activity were calculated and compared between males and females. Interhemispheric correlation of the theta rhythm was highe...

journal_title：Brain research bulletin

authors： Juárez J,Corsi-Cabrera M

更新日期：1995-01-01 00:00:00

abstract：:According to recently published papers acylated-ghrelin (A-Ghr) modifies memory and learning. The basolateral nucleus of amygdala (ABL) participates in the regulation of memory and learning mechanisms. Previously we verified A-Ghr responsive neurons in the ABL by electrophysiological methods. In male Wistar rats effec...

journal_title：Brain research bulletin

authors： Tóth K,László K,Lénárd L

更新日期：2010-01-15 00:00:00

abstract：:Several lines of evidence have established that performance during the initial steps of acquisition on a shuttle-box avoidance task is an anxiety-mediated behavior (i.e., the differences between strains selectivity bred for emotionality; the effects of postnatal handling; the course of the corticosterone response and ...

journal_title：Brain research bulletin

authors： Fernández-Teruel A,Escorihuela RM,Núñez JF,Zapata A,Boix F,Salazar W,Tobeña A

更新日期：1991-01-01 00:00:00

abstract：:Binary mixtures of acid with salt were observed to produce enhancing effects on oral chemoreceptor responses by recording the activity of the whole glossopharyngeal nerve of the clawed toad (Xenopus laevis). The mixtures of HCl with various inorganic salts elicited responses larger than the sum of the responses to ind...

journal_title：Brain research bulletin

authors： Yamashita S,Hisadome K,Yotsumata Y,Kiyohara S

更新日期：1997-01-01 00:00:00

abstract：:Plasma gonadotropins, prolactin and hypothalamic tyrosine hydroxylase (TH) activity were evaluated at 15 and 30 min after third ventricular injection of bombesin at doses of 100 or 1000 ng and secretin at doses of 1000 and 5000 ng in ovariectomized (OVX) unanesthetized rats. Bombesin had no effect on plasma gonadotrop...

journal_title：Brain research bulletin

authors： Babu GN,Vijayan E

更新日期：1983-07-01 00:00:00

abstract：:Recent investigations of the nucleus ambiguus (NA) have attempted to identify motoneurons associated with the branchiomeric muscles of the larynx and pharynx. However, relatively little attention has been directed to the levator veli palatini muscle (LVP) which is critical in respiration, deglutition and eustachian tu...

journal_title：Brain research bulletin

authors： van Loveren H,Saunders MC,Keller JT

更新日期：1983-09-01 00:00:00

abstract：:We have examined the effects of the presence of the mutated human presenilin 1 gene (M146L; hps1*) on lesion-induced sprouting in the hippocampus of the mouse (C57/CBA). The entorhinal cortex was unilaterally lesioned with ibotenic acid in adult, male mice. Four weeks later the subsequent axonal sprouting in the denta...

journal_title：Brain research bulletin

authors： Kadish I,Pradier L,van Groen T

更新日期：2002-03-15 00:00:00

abstract：:It was found that neurons in the posterior orbitofrontal cortex, area 13, of the rhesus monkey were activated from self-stimulation electrodes (in 142 of 168 possible instances), and that neurons in the anterior orbitofrontal areas were much less likely to be activated from the self-stimulation electrodes (in only 28 ...

journal_title：Brain research bulletin

authors： Mora F,Avrith DB,Rolls ET

更新日期：1980-03-01 00:00:00

abstract：:Trans-2, 4-dimethoxystibene (S3) is a synthetic stilbenes. In the present study, S3 was investigated to assess its neuroprotective effect against the toxicity induced by Abeta(25-35) in hypercholesterolemic rats. Rats were fed with hypercholesterolemic chow for six weeks, and then received a single intracerebroventric...

journal_title：Brain research bulletin

authors： Ruan CJ,Li Z,Zhang L,Chen DH,Du GH,Sun L

更新日期：2010-07-30 00:00:00

abstract：:The effects of ventral amygdalofugal pathways (VAF) or stria terminalis (ST) on the hypothalamic aggressive-defense (rage) reaction were examined in fifteen cats. After bilateral electrolytic lesions of the VAF or ST, 0.5 pmol of acetylcholine (ACh) was injected into the VMH and electrical stimulation was applied. The...

journal_title：Brain research bulletin

authors： Kono R,Tashiro N,Nakao H

更新日期：1986-04-01 00:00:00

abstract：:In precollicular decerebrate cats, the vestibulospinal reflex (VSR) was intermittently recorded from the triceps brachii during sinusoidal roll tilt of the whole animal (at 0.15 Hz, +/- 10 degrees), leading to selective stimulation of labyrinth receptors. This reflex, tested during and after a 3-h period of sustained ...

journal_title：Brain research bulletin

authors： Pompeiano O,Manzoni D,D'Ascanio P,Andre P

更新日期：1994-01-01 00:00:00

abstract：:The serotonin(2A) (5HT(2A)) receptors have been shown to play an important role in several psychiatric disorders, including depression, schizophrenia, and alcoholism. This immunohistochemical study examined the cellular localization of 5HT(2A) receptors in various rat brain structures (olfactory, striatum, cortex, hip...

journal_title：Brain research bulletin

authors： Xu T,Pandey SC

更新日期：2000-04-01 00:00:00

abstract：:Electrogastrography (EGG) is a noninvasive measurement of stomach activity using surface electrodes positioned over the abdominal surface. For over 10 years, EGG has been used as an objective measure of epigastric symptoms and nausea experienced in visually induced sickness provoked by circularvection. It was reported...

journal_title：Brain research bulletin

authors： Cheung B,Vaitkus P

更新日期：1998-11-15 00:00:00

abstract：:An animal with an unimpaired "reference" memory can distinguish between alternatives that belong to a rewarded set and those that are unrewarded. An animal with an unimpaired "working" memory can distinguish between alternatives where it has been rewarded (e.g., food has been eaten and not replaced) and those where it...

journal_title：Brain research bulletin

authors： Oades RD

更新日期：1981-08-01 00:00:00

abstract：:Sexually relevant pheromonal cues are detected by the vomeronasal system which includes the posterodorsal part of the medial amygdala, the posteromedial part of the bed nucleus of the stria terminalis and the medial preoptic area. Copulatory behavior is impaired in mice lacking functional aromatase, the enzyme convert...

journal_title：Brain research bulletin

authors： Aste N,Honda S,Harada N

更新日期：2003-05-15 00:00:00

abstract：:Fluoro-Ruby (tetramethylrhodamine-dextran amine conjugate) has been shown recently to be an effective anterograde tracer readily visible in brain sections with fluorescence microscopy. We show in this study that further microscopic analysis of Fluoro-Ruby-labeled elements is feasible with a conventional immunoperoxida...

journal_title：Brain research bulletin

authors： Chang HT

更新日期：1993-01-01 00:00:00

abstract：:The development of morphine-induced antinociceptive tolerance limits its therapeutic efficacy in pain management. Atorvastatin, or competitive inhibitor of 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase, is mainstay agent in hypercholesterolemia treatment. Beyond the cholesterol-lowering activity, exploratio...

journal_title：Brain research bulletin

authors： Hassanipour M,Amini-Khoei H,Shafaroodi H,Shirzadian A,Rahimi N,Imran-Khan M,Rezayat SM,Dehpour A

更新日期：2016-07-01 00:00:00

abstract：:The central GABAergic system is associated with normal blood pressure regulation, but the role of GABA receptors in genetic hypertension remains unclear. This study was conducted to investigate GABAA receptor binding in several brain regions of spontaneously hypertensive (SHR) rats during development of hypertension. ...

journal_title：Brain research bulletin

authors： Kunkler PE,Hwang BH

更新日期：1995-01-01 00:00:00

abstract：:Progesterone receptor (PR) isoforms expression was determined in several regions of the prepuberal and adult male rat brain by using reverse transcription coupled to polymerase chain reaction. Rats under a 14:10-h light-dark cycle, with lights on at 0600 h were used. We found that in the hypothalamus of prepuberal ani...

journal_title：Brain research bulletin

authors： Guerra-Araiza C,Reyna-Neyra A,Salazar AM,Cerbón MA,Morimoto S,Camacho-Arroyo I

更新日期：2001-01-01 00:00:00

abstract：:In vitro and in vivo studies have demonstrated that lithium treatment can protect neurons against excitotoxic and ischemic damage. Yet the possible beneficial effect of chronic low dose lithium on a model of traumatic brain injury (TBI) has not been intensively investigated. In this study, lithium (1 mmol/kg) was give...

journal_title：Brain research bulletin

authors： Zhu ZF,Wang QG,Han BJ,William CP

更新日期：2010-10-30 00:00:00

abstract：:The central anti-nociception of BmK IT2, a sodium channel modulator from scorpion Buthus martensi Karsh (BmK) was investigated in this study. It was found that the formalin-induced rat spontaneous flinches and spinal c-Fos expression could be significantly suppressed by intrathecal BmK IT2 pre- or post-formalin inject...

journal_title：Brain research bulletin

authors： Bai ZT,Liu T,Pang XY,Chai ZF,Ji YH

更新日期：2007-07-12 00:00:00

abstract：:IN anesthetized and paralyzed rabbits, action potentials were elicited antidromically following electrical stimulation of optic tract terminals at the geniculate level (LGN). The conduction velocity spectrum extended from 7 m.s-1 to 34 m.s-1. The distribution of conduction velocities indicated four major modes at 10, ...

journal_title：Brain research bulletin

authors： Molotchnikoff S,Lessard I

更新日期：1980-11-01 00:00:00

abstract：:The development of central serotonergic neurons has been examined immunocytochemically utilizing an antiserum to serotonin (5-HT). Cells of the B4-B9 complex are first detected early on embryonic day 13 (E13; 7 mm crown rump length, CRL) and increase rapidly in number through E15 when they appear as bilateral columns ...

journal_title：Brain research bulletin

authors： Wallace JA,Lauder JM

更新日期：1983-04-01 00:00:00