Quipazine has a biphasic effect on slow wave sleep and reduces REM sleep rebound in REM sleep deprived rats.

Abstract:

:Rats implanted with electrodes for polygraphic recording were deprived of REM sleep for 24 hr. Following REM sleep deprivation animals were injected with quipazine maleate (7.5 mg/kg IP) and were polygraphically recorded for 48 hr. The results show that quipazine reduces REM sleep rebound and that it has a biphasic effect on slow-wave sleep: initial 6 hr suppression is followed by a delayed increase in the second 24 hr recording period. The initial suppression of slow-wave sleep we attribute to the stimulation of central serotonergic receptors while the effect on REM sleep rebound may result from quipazine's action on central catecholamines.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Zak R,Radulovacki M

doi

10.1016/0361-9230(82)90067-3

subject

Has Abstract

pub_date

1982-03-01 00:00:00

pages

329-31

issue

3

eissn

0361-9230

issn

1873-2747

pii

0361-9230(82)90067-3

journal_volume

8

pub_type

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