Abstract:
:Microinjection of galanin into the paraventricular nucleus (PVN) of the hypothalamus has been reported to predominantly increase dietary fat consumption during the light or late dark periods. However, there have been no studies of the macronutrient-specific effects of galanin administered into the amygdala (AMY). We used male Sprague-Dawley rats to test the effect of galanin administered into the PVN or central nucleus of the AMY on diet selection using two different protocols: the two-choice composite diet (10% or 55% energy as fat) (Study 1) or the three-choice macronutrient diet (Study 2). In the first study, total food intake was significantly increased 60 min after galanin injection (0.3 nmol) into either the PVN or AMY, but there was no difference in intake between the low- and high-fat diets. In Study 2, using the three-choice macronutrient diet, the feeding stimulation produced by galanin in the PVN also was not diet-dependent. In the AMY, there was a significant effect of diet on the feeding response to galanin, due primarily to the lack of stimulation of protein intake, whereas the intakes of fat and carbohydrate were not significantly different. In summary, there was no difference in the effect of galanin on fat versus carbohydrate intake for either nuclei, whether animals were injected during the light or the late-dark phase. Because rats often display preferences when allowed to choose among individual macronutrient sources, we also examined the relationship between baseline macronutrient preference and the feeding response to galanin in groups of highly fat-preferring and carbohydrate-preferring rats (Study 3). After PVN galanin injection, fat-preferring rats demonstrated significant increases in their consumption of both carbohydrate and fat, whereas carbohydrate-preferring rats responded by eating carbohydrate almost exclusively. There were significant positive associations between baseline macronutrient intake and galanin-induced intake. The results of these studies combined suggest that the effect of galanin on macronutrient selection is not specific for fat and that underlying macronutrient preferences are important in determining the feeding response to galanin.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Smith BK,York DA,Bray GAdoi
10.1016/0361-9230(95)02086-1subject
Has Abstractpub_date
1996-01-01 00:00:00pages
149-54issue
3eissn
0361-9230issn
1873-2747pii
0361-9230(95)02086-1journal_volume
39pub_type
杂志文章abstract::Our previous results showed that neurochemical destruction of the amygdaloid terminal field of the mesolimbic dopaminergic system caused disturbances in body weight regulation and feeding. In the present experiments, it was studied whether 6-hydroxydopamine (6-OHDA)-induced bilateral lesions of the mesolimbic dopamine...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90125-4
更新日期:1991-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90272-d
更新日期:1993-01-01 00:00:00
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journal_title:Brain research bulletin
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更新日期:2011-08-10 00:00:00
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journal_title:Brain research bulletin
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doi:10.1016/0361-9230(81)90086-1
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:2003-04-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(78)90085-0
更新日期:1978-09-01 00:00:00
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更新日期:2000-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90036-j
更新日期:1991-11-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2018.02.019
更新日期:2018-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(87)90139-0
更新日期:1987-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2013.04.006
更新日期:2013-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:2019-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(89)90133-0
更新日期:1989-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(02)00948-6
更新日期:2003-02-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.07.002
更新日期:2005-10-15 00:00:00
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journal_title:Brain research bulletin
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doi:10.1016/j.brainresbull.2008.09.014
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90070-z
更新日期:1991-08-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90044-k
更新日期:1991-11-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1982-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2016.05.009
更新日期:2016-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90079-5
更新日期:1983-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90240-x
更新日期:1992-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90177-y
更新日期:1992-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90021-3
更新日期:1994-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90125-2
更新日期:1994-01-01 00:00:00