Abstract：
:Although the huge economic and social impact and the predicted incidence increase, neuroprotection for ischemic stroke remains as a therapeutically empty niche. In the present study, we investigated the rationale of the C-Phycocyanin (C-PC) treatment on global cerebral ischemia/reperfusion (I/R) injury in gerbils. We demonstrated that C-PC given either prophylactically or therapeutically was able to significantly reduce the infarct volume as assessed by triphenyltetrazolium chloride (TTC) staining and the neurological deficit score 24h post-stroke. In addition, C-PC exhibited a protective effect against hippocampus neuronal cell death, and significantly improved the functional outcome (locomotor behavior) and gerbil survival after 7 days of reperfusion. Malondialdehyde (MDA), peroxidation potential (PP) and ferric reducing ability of plasma (FRAP) were assayed in serum and brain homogenates to evaluate the redox status 24h post-stroke. The treatment with C-PC prevented the lipid peroxidation and the increase of FRAP in both tissue compartments. These results suggest that the protective effects of C-PC are most likely due to its antioxidant activity, although its anti-inflammatory and immuno-modulatory properties reported elsewhere could also contribute to neuroprotection. To our knowledge, this is the first report of the neuroprotective effect of C-PC in an experimental model of global cerebral I/R damage, and strongly indicates that C-PC may represent a potential preventive and acute disease modifying pharmacological agent for stroke therapy.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Pentón-Rol G,Marín-Prida J,Pardo-Andreu G,Martínez-Sánchez G,Acosta-Medina EF,Valdivia-Acosta A,Lagumersindez-Denis N,Rodríguez-Jiménez E,Llópiz-Arzuaga A,López-Saura PA,Guillén-Nieto G,Pentón-Arias Edoi
10.1016/j.brainresbull.2011.05.016subject
Has Abstractpub_date
2011-08-10 00:00:00pages
42-52issue
1-2eissn
0361-9230issn
1873-2747pii
S0361-9230(11)00180-8journal_volume
86pub_type
杂志文章abstract：:The vestibulo-ocular reflex (VOR) has historically been considered a computationally simple reflex: to stabilize images on the retina against imposed head rotation, the eyes must be counterrotated by an equal amount in the opposite direction. During almost any head rotation, however, the eyes are also translated. We s...
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pub_type： 评论,杂志文章
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journal_title：Brain research bulletin
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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