beta-Amyloid-induced toxicity in rat hippocampal cells: in vitro evidence for the involvement of free radicals.

Abstract:

:The conditions under which amyloid is toxic to primary rat hippocampal neurons were investigated. Synthetic A beta (1-42) peptide elicited neurotoxic activity following "aging" for 7 to 14 days at 37 degrees C in Modified Eagles Media. Neurotoxicity included decreases in neurite length, cell number, and a loss in 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide reduction. In contrast, the addition of the media supplement B27, during the aging process, promoted the neurotrophic actions of aged A beta (1-42), as indicated by an increase in neurite length and the number of cells possessing neurites, and attenuated toxicity. The differences in the biological actions elicited by these two preparations of aged peptide were attributed to the presence of the B27 components. B27 consists of a mixture of agents that provide protection against oxidative damage. In support, aging A beta (1-42) in the presence of superoxide dismutase and catalase, two components of B27, significantly reduced the toxic actions of peptide; hence, suggesting that free radicals may be required for the toxicity that accumulates during the aging of the peptide. To determine the contribution of particular amino acid residues in amyloid toxicity, studies were carried out with an aged preparation of the A beta (1-42) analog, A beta (1-42)Nle35. Findings from these studies suggest that the methionine residue may play a part, but is not required, for amyloid toxicity to occur.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Manelli AM,Puttfarcken PS

doi

10.1016/0361-9230(95)02034-x

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

569-76

issue

6

eissn

0361-9230

issn

1873-2747

pii

036192309502034X

journal_volume

38

pub_type

杂志文章
  • Dopamine in the hippocampal dentate gyrus modulates spatial learning via D1-like receptors.

    abstract::Increasing evidence supports that dopamine (DA) plays an important role in the hippocampal function via activation of D1-like receptors (D1Rs). As the entry structure of the hippocampal formation, the hippocampal dentate gyrus (DG) is critically involved in spatial learning and memory. Despite a number of studies inve...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2018.11.010

    authors: Wang F,Wan P,Wang W,Xiao B,Jin H,Jin Q

    更新日期:2019-01-01 00:00:00

  • REM-dreams recall in patients with narcolepsy-cataplexy.

    abstract::An abundant recall of dreams has been observed in clinical studies on patients with narcolepsy-cataplexy (NC), a neurological disorder characterized by an altered sleep architecture. Laboratory studies have shown that dream experiences developed during 1st-rapid eye movement (REM) sleep by NC patients are longer and m...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2009.10.021

    authors: Mazzetti M,Bellucci C,Mattarozzi K,Plazzi G,Tuozzi G,Cipolli C

    更新日期:2010-01-15 00:00:00

  • Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice.

    abstract::Aβ plaques of Alzheimer's disease (AD) are believed to precede cognitive deficits or clinical manifestation by decades. However, validated biomarkers for early diagnosis of the AD disease are still not available. In this present study, we combined MRI-based neuroimages and histological assessment of the glial response...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2020.01.003

    authors: Liu L,Liu Y,Li N,Huang R,Zheng X,Huang L,Hou S,Yuan Q

    更新日期:2020-03-01 00:00:00

  • Clozapine increased c-Fos protein expression in several brain subregions of socially isolated rats.

    abstract::Chronic social stress and/or pharmacological treatments differentially modulate the expression of c-Fos, a marker of neuronal activity, in subregions of the rat brain. Here, we examined the effect of the atypical antipsychotic Clozapine (Clz) (20 mg/kg/day for 3 weeks) on the neuronal activation pattern of c-Fos prote...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2019.07.005

    authors: Stanisavljević A,Perić I,Bernardi RE,Gass P,Filipović D

    更新日期:2019-10-01 00:00:00

  • Termination of trigeminal primary afferents on glossopharyngeal-vagal motoneurons: possible neural networks underlying the swallowing phase and visceromotor responses of prey-catching behavior.

    abstract::Prey-catching behavior (PCB) of the frog consists of a sequence of coordinated activity of muscles which is modified by various sensory signals. The aim of the present study was, for the first time, to examine the involvement of the trigeminal afferents in the swallowing phase of PCB. Experiments were performed on Ran...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2013.09.006

    authors: Kecskes S,Matesz C,Birinyi A

    更新日期:2013-10-01 00:00:00

  • Effect of avian basal forebrain lesions, including septum, on heart rate conditioning.

    abstract::The possible involvement of basal telencephalic structures in visually conditioned heart rate change (established by pairing light and foot-shock) was studied in 156 pigeons by evaluating conditioning performance following lesions of the septum or lobus parolfactorius. Extensive destruction of the septal complex had n...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(78)90098-9

    authors: Cohen DH,Goff DM

    更新日期:1978-07-01 00:00:00

  • Microarray assay of circular RNAs reveals cicRNA.7079 as a new anti-apoptotic molecule in spinal cord injury in mice.

    abstract::Traumatic spinal cord injury (SCI) can lead to motor disturbance, sensory deficit, or autonomic dysfunction. The role of circRNAs in the pivotal physiopathological processes of SCI has been demonstrated recently. However, no similar research has been performed to explore the circRNAs involved in apoptosis after SCI. T...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2020.08.004

    authors: Yao Y,Wang J,He T,Li H,Hu J,Zheng M,Ding Y,Chen YY,Shen Y,Wang LL,Zhu Y

    更新日期:2020-11-01 00:00:00

  • Morphine pretreatment increases opioid inhibitory effects on maternal behavior.

    abstract::Ongoing maternal behavior in rats is under the inhibitory influence of opiates. Exposure to drugs of abuse may result in a progressive and enduring enhancement of their reinforcing effects. Little attention has been paid to the possibility that puerperal treatment with morphine may lead to sensitization to this drug, ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(01)00549-4

    authors: Miranda-Paiva CM,Nasello AG,Yin AJ,Felicio LF

    更新日期:2001-07-01 00:00:00

  • Glutamate stimulation of acetylcholine release from myenteric plexus is mediated by endogenous nitric oxide.

    abstract::Glutamate was found to be an excitatory neurotransmitter in the enteric nervous system. Although several lines of evidence indicate a role of glutamate in the regulation of gut motility and secretion the physiological significance of glutamatergic transmission is not clear yet. We studied the effect of glutamate on [3...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2005.05.011

    authors: Milusheva EA,Kuneva VI,Itzev DE,Kortezova NI,Sperlagh B,Mizhorkova ZN

    更新日期:2005-08-15 00:00:00

  • The effect of ACTH4-10 on protein synthesis, actin and tubulin during regeneration.

    abstract::The effects of ACTH4-10, a peptide fragment of corticotropin, on rat dorsal root ganglia (DRG), spinal cord and sciatic nerve were studied following a crush lesion of the sciatic nerve. The in vitro total protein synthesis rate of DRG L4, L5 and L6, measured one and three days after ipsilateral nerve crush, were not a...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(85)90149-2

    authors: Edwards PM,Verhaagen J,Spierings T,Schotman P,Jennekens FG,Gispen WH

    更新日期:1985-09-01 00:00:00

  • Recovery of function after brain damage: the extrinsic stimulus specificity of spared neural traces.

    abstract::Previous research has demonstrated that while primary visual cortex lesions in rats will disrupt performance of a learned brightness discrimination, the neural traces associated with this discrimination are spared. Moreover, the spared neural traces may, in certain instances, influence the postoperative reinstatement ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(78)90058-8

    authors: Levere TE,Davis N,Fontaine CW

    更新日期:1978-01-01 00:00:00

  • HLY78 protects blood-brain barrier integrity through Wnt/β-catenin signaling pathway following subarachnoid hemorrhage in rats.

    abstract::Wnt/β-catenin signaling plays an essential role in blood-brain barrier (BBB) formation and maintenance under pathophysiological conditions. HLY78, a lycorine derivative, has been identified as a novel activator of Wnt/β-catenin signaling in vitro. However, the effects of HLY78 on the BBB function in subarachnoid hemor...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2020.06.003

    authors: Luo X,Li L,Zheng W,Gu L,Zhang X,Li Y,Xie Z,Cheng Y

    更新日期:2020-09-01 00:00:00

  • Recovery of function in spinalized, neonatal rats.

    abstract::Neonatal rats, when spinalized on the fourteenth postnatal day, showed minimal recovery of function in their hindlimbs. Bridging the cut spinal cord with E16 fetal spinal cord tissue did not improve functional recovery. Bridging, plus treatment with GM1 ganglioside, caused a significant (p less than 0.05) improvement ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(91)90272-l

    authors: Commissiong JW,Sauve Y,Csonka K,Karoum F,Toffano G

    更新日期:1991-07-01 00:00:00

  • Ethyl-EPA in Huntington disease: potentially relevant mechanism of action.

    abstract::The pathomechanisms involved in the neuronal dysfunction in Huntington disease (HD) are still unresolved and may be heterogeneous. One potential mechanism might be related to the induction of mitochondrial dysfunction in the CNS. This might lead firstly to neuronal dysfunction and finally to the activation of apoptoti...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainresbull.2006.10.020

    authors: Murck H,Manku M

    更新日期:2007-04-30 00:00:00

  • The effect of exercise and nettle supplementation on oxidative stress markers in the rat brain.

    abstract::Chronic swimming training and phytotherapeutic supplementation are assumed to alleviate oxidative damage, and support cell survival in the brain. The effect of forced, chronic swimming training, and enriched lab chow containing 1% (w/w) dried nettle (Urtica dioica) leaf were investigated for oxidative stress, inflamma...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2005.02.028

    authors: Toldy A,Stadler K,Sasvári M,Jakus J,Jung KJ,Chung HY,Berkes I,Nyakas C,Radák Z

    更新日期:2005-05-30 00:00:00

  • Widespread dopaminergic projections of the subparafascicular thalamic nucleus in the rat.

    abstract::The subparafascicular thalamic nucleus (Spf) contains a substantial number of dopaminergic neurons. The present study was designed to investigate in the rat whether or not Spf neurons projecting to a variety of central nervous system structures are dopaminergic. The following eight structures were tested for projectio...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(93)90191-d

    authors: Takada M

    更新日期:1993-01-01 00:00:00

  • Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B.

    abstract::The availability of mutant mice that lack either MAO A or MAO B has created unique profiles in the central and peripheral availability of serotonin, norepinephrine, dopamine, and phenylethylamine. This paper summarizes some of the current known phenotypic findings in MAO A knock-out mice and contrast these with those ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/s0361-9230(01)00613-x

    authors: Holschneider DP,Chen K,Seif I,Shih JC

    更新日期:2001-11-15 00:00:00

  • Phenotypic characteristics of hybrid cells generated by transferring neuronal nuclei into bone marrow stromal cell cytoplasts.

    abstract::Bone marrow stromal cells (BMSCs) are promising donor cells for transplantation therapies for a variety of diseases. However, there still lack efficient ways to induce directional differentiation of BMSCs to promote their practical use in transplantation therapy. In this study, we constructed hybrid cells by transferr...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2011.11.001

    authors: Zhou Z,Xu Y,Zhong Q,Zheng J

    更新日期:2012-02-10 00:00:00

  • Temporal and regional expression of Fos-related proteins in response to ischemic injury.

    abstract::The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for contr...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2003.12.005

    authors: Butler TL,Pennypacker KR

    更新日期:2004-03-01 00:00:00

  • Cytoarchitecture of nitrergic neurons in the human striatum and subthalamic nucleus.

    abstract:BACKGROUND:Nitric oxide (NO) is a gaseous molecule that modulates several physiological processes, including signal transmission in the central nervous system. There is evidence supporting NO as a major neurotransmitter involved in motor and emotion/behavior control. We investigated the distribution and morphology of n...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2016.04.003

    authors: Santos-Lobato BL,Del-Bel E,Pittella JE,Tumas V

    更新日期:2016-06-01 00:00:00

  • Control of the body vertical by vestibular and proprioceptive inputs.

    abstract::The study examines the influence of vestibular and leg proprioceptive cues on the maintenance of the body vertical in human stance. Vestibular body orientation cues were changed by applying bipolar currents to both mastoid bones (cosine-bell wave form of 3.3 s duration, 1 mA current intensity). Proprioceptive input wa...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(96)00138-4

    authors: Hlavacka F,Mergner T,Krizkova M

    更新日期:1996-01-01 00:00:00

  • Repeated cocaine treatment alters tyrosine hydroxylase in the rat nucleus accumbens.

    abstract::To determine whether repeated exposure of cocaine affects the dopaminergic innervation of the nucleus accumbens, we employed a typical cocaine-dosing regimen in adult male Sprague-Dawley rats followed by an immunocytochemical analysis of tyrosine hydroxylase (TH). Treatment consisted of bi-daily injections of saline o...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(00)00277-x

    authors: Todtenkopf MS,De Leon KR,Stellar JR

    更新日期:2000-07-15 00:00:00

  • Effects of ovarian steroids on serotonin metabolism within grossly dissected and microdissected brain regions of the ovariectomized rat.

    abstract::Brain serotonin (5-HT) levels and accumulation rate within the dorsal raphe nucleus (DR) were elevated in ovariectomized (OVX) rats after ovarian steroid treatment, which consisted of estradiol benzoate (EB) followed by progesterone (P) 48 hr later. Some animals were also given the monoamine oxidase (MAO) inhibitor pa...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(81)90111-8

    authors: Cone RI,Davis GA,Goy RW

    更新日期:1981-12-01 00:00:00

  • Cholinergic, noradrenergic, and serotonergic inhibition of fast synaptic transmission in spinal lumbar dorsal horn of rat.

    abstract::It is known that spinal nociceptive sensory transmission receives descending inhibitory and facilitatory modulation from supraspinal structures. Glutamate is the major fast excitatory transmitter between primary afferent fibers and spinal dorsal horn neurons. In whole-cell patch clamp recordings from dorsal horn neuro...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(01)00470-1

    authors: Li P,Zhuo M

    更新日期:2001-04-01 00:00:00

  • Non-invasive brain stimulation (rTMS and tDCS) in patients with aphasia: mode of action at the cellular level.

    abstract::A high proportion of patients who have suffered a stroke also suffer from aphasia. Approximately half of those affected will remain in this state despite intensive language therapy. Non-invasive brain stimulation allows us to directly and focally stimulate areas of the brain. Repetitive transcranial magnetic stimulati...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainresbull.2013.07.005

    authors: Málly J

    更新日期:2013-09-01 00:00:00

  • Effects of beta-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: further evidence of antidepressant properties.

    abstract::The chronic mild stress (CMS) model has been used as an animal model of depression which induces anhedonic behavior in rodents. The present study was aimed to evaluate the behavioral and physiological effects of administration of beta-carboline harmine in rats exposed to CMS procedure. To this aim, after 40 days of ex...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2009.09.008

    authors: Fortunato JJ,Réus GZ,Kirsch TR,Stringari RB,Fries GR,Kapczinski F,Hallak JE,Zuardi AW,Crippa JA,Quevedo J

    更新日期:2010-03-16 00:00:00

  • Fe(2+) and Fe(3+) in micromolar concentrations modulate glycine-induced Cl(-) current in rat hippocampal neurons.

    abstract::The effects of Fe(2+) and Fe(3+) on glycine-activated chloride current (IGly) were studied in rat isolated pyramidal hippocampal neurons using patch-clamp technique in whole-cell configuration. 25, 100 or 500 μM glycine was applied for 600 ms with 40s intervals. Fe(2+) and Fe(3+) were co-applied with glycine in the ra...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2015.04.004

    authors: Solntseva EI,Bukanova JV,Kondratenko RV,Skrebitsky VG

    更新日期:2015-06-01 00:00:00

  • Changes of K+ -Cl- cotransporter 2 (KCC2) and circuit activity in propofol-induced impairment of long-term potentiation in rat hippocampal slices.

    abstract::Enhancing inhibition via gamma-aminobutyric acid type A (GABA(A)) receptors contributes to anesthetic-induced impairment of long-term potentiation (LTP) of excitatory synaptic transmission, which may account for general anesthesia-associated memory impairment (amnesia). The neuron-specific K+ -Cl- cotransporter 2 (KCC...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2006.07.004

    authors: Wang W,Wang H,Gong N,Xu TL

    更新日期:2006-10-16 00:00:00

  • Neuroeconomics: an overview from an economic perspective.

    abstract::Until now, economic theory has not systematically integrated the influence of emotions on decision-making. Since evidence from neuroscience suggests that decision-making as hypothesized in economic theory depends on prior emotional processing, interdisciplinary research under the label of "neuroeconomics" arose. The k...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainresbull.2005.07.006

    authors: Kenning P,Plassmann H

    更新日期:2005-11-15 00:00:00

  • Rapid differentiation of NT2 cells in Sertoli-NT2 cell tissue constructs grown in the rotating wall bioreactor.

    abstract::Cell replacement therapy is of great interest as a long-term treatment of neurodegenerative diseases such as Parkinson's disease (PD). We have previously shown that Sertoli cells (SC) provide neurotrophic support to transplants of dopaminergic fetal neurons and NT2N neurons, derived from the human clonal precursors ce...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2004.09.003

    authors: Saporta S,Willing AE,Shamekh R,Bickford P,Paredes D,Cameron DF

    更新日期:2004-12-15 00:00:00