Abstract:
:The effects of systemic injections of amphetamine sulfate on the extracellular levels of glycine, GABA, and taurine in the neostriatum of awake rats were studied using a push-pull perfusion system. Amphetamine produced a dose-related increase in glycine levels. Amphetamine also produced an enhancement on GABA and taurine levels, although these increases did not follow a dose-related curve. The percentage increase of amino acids produced by the highest dose of amphetamine (5 mg/kg) at the peak effect was: GLY 235.9%; GABA 218%, and TAU 177%. All these effects were blocked by the D1-D2 dopamine receptor antagonist, haloperidol. It is suggested that dopamine, released by amphetamine, induces the release of inhibitory amino acid neurotransmitters in the neostriatum. These results are consistent with the hypothesis of dopamine playing a role of an amplifier of the activity of different neurochemical circuits. The results are also in accord with the idea that dopamine could mediate the neurotoxic effects produced by amphetamines through an interplay between excitatory and inhibitory amino acids.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Porras A,Mora Fdoi
10.1016/0361-9230(93)90222-wsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
305-10issue
3-4eissn
0361-9230issn
1873-2747pii
0361-9230(93)90222-Wjournal_volume
31pub_type
杂志文章abstract::The localization of CGRP mRNA in neurons of the rat brain and spinal cord was assessed by in situ hybridization histochemistry (ISH) using a radiolabeled synthetic 57-mer oligodeoxynucleotide probe complementary to the rat prepro CGRP mRNA. Results were compared with previously published findings of CGRP-immunoreactiv...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)00201-b
更新日期:1995-01-01 00:00:00
abstract::The effects of two diketopiperazines, Cyclo (His-Pro) (CHP) and Cyclo (Asp-Phe) (CAP), on striatal extracellular levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) were examined using in vivo microdialysis in anaesthetized rats. Treatment with ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90171-7
更新日期:1993-01-01 00:00:00
abstract::The present study in piglets was designed to examine cerebrovascular effects of tumor necrosis factor-alpha (TNF alpha) and potential mechanisms involved. Anesthetized new-born pigs with closed cranial windows implanted were used. Effects of nitric oxide synthase (NOS) inhibitors, NG-nitro-L-arginine (L-NNA) and amino...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(95)02142-6
更新日期:1996-01-01 00:00:00
abstract::Klotho, which is a life extension factor, and erythropoietin (EPO) have been introduced as effective neuroprotective factors in several neurological disorders. The present study is an attempt to examine the potential role of klotho and EPO in therapeutic effect of curcumin-loaded nanoparticles (NPs) in pentylenetetraz...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2018.08.010
更新日期:2018-09-01 00:00:00
abstract::We have previously demonstrated that chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) infusion to the substantia nigra (SN) and the locus coeruleus (LC) both produce a long-lasting neurotoxicity on dopamine (DA) and norepinephrine (NE) neurons in these two areas, respectively. In the present study, we furth...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90215-w
更新日期:1993-01-01 00:00:00
abstract::Bacillus Calmette-Guérin (BCG) is administered to neonates worldwide, but it is still unknown whether this neonatal vaccination affects brain development during early postnatal life, despite the close association of the immune system with the brain. Newborn C57BL/6 mice were injected subcutaneously with BCG or phospha...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2015.10.012
更新日期:2016-01-01 00:00:00
abstract::Saturation and competition binding studies showed that the turtle brain contains sigma sites labeled by both [3H]di-o-tolylguanidine (DTG) and [3H](+)-pentazocine. There was a significant correlation between the IC50 values of sigma ligands for [3H]DTG sites in the turtle vs. rat brain, suggesting that the sites are c...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(99)00029-5
更新日期:1999-03-15 00:00:00
abstract::The effects of intracerebroventricular (ICV) injection of neuropeptide Y (NPY) on parameters of dopamine (DA), glutamate (Glu) and gamma-aminobutyric acid (GABA) activities were investigated in the rat striatum. NPY (1.17-4.70 nmol) induced a dose-dependent increase in the striatal endogenous DA release monitored in f...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90178-z
更新日期:1992-02-01 00:00:00
abstract::Mutations in PLA2G6, which encodes calcium-independent phospholipase A(2) group VIA (iPLA2-VIA), underlie the autosomal recessive disorder infantile neuroaxonal dystrophy (INAD). INAD typically presents in the first year of life, and leads to optic atrophy and psychomotor regression. We have examined PLA2G6 expression...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2010.08.011
更新日期:2010-11-20 00:00:00
abstract::It is well known that some epileptic patients does not respond to conventional treatments, despite multiple combination of antiepileptic drugs, and they are therefore considered drug-resistant. For these patients, vagal nerve stimulation (VNS) represents a successful alternative to traditional therapy, and it is gener...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2007.02.004
更新日期:2007-06-15 00:00:00
abstract::The use of a new and very sensitive immunohistochemical method, combined with intracerebral injections of colchicine, has allowed us to show that a number of nerve cell bodies immunoreactive for Met-enkephalin are present in several mesencephalic nuclei of the rat, including the different subdivisions of the substanti...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90275-o
更新日期:1991-07-01 00:00:00
abstract::Arachidonic acid [20:4(N-6)] has been implicated in neurological damage induced by cerebral ischaemia. Membrane arachidonate concentrations can be reduced by changes in dietary fat intake. Therefore, in the present study, we have investigated the effects of N-3 fatty acid supplementation on neuronal damage induced by ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90180-j
更新日期:1993-01-01 00:00:00
abstract::gamma-Aminobutyric acid (GABA) is considered a major inhibitory neurotransmitter in the generation of presynaptic inhibition at central terminals of primary afferent fiber (PAF), while it has also been established that nitric oxide (NO) may sensitize the terminals of nocisponsive PAFs and enhance neuropeptide release,...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00500-7
更新日期:2001-06-01 00:00:00
abstract::The claustrum is a relatively large telencephalic structure, situated close to the border of the neo- and allocortical regions. Its neuronal population consists of glutamatergic, projecting neurons and GABA-ergic interneurons, characterized by occurrence of numerous additional biochemical markers. The postnatal develo...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2009.06.020
更新日期:2009-09-28 00:00:00
abstract::This study tests the influence of transcranial magnetic stimulation (TMS) of the posterior parietal cortex (PPC) on the initiation of horizontal and vertical saccades, alone or combined with a predictable divergence. A gap paradigm was used; TMS was applied 100 ms after target onset. TMS of the left PPC increased the ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2007.11.007
更新日期:2008-05-15 00:00:00
abstract::Depression is a state of low mood and aversion to activity, affecting a person's thoughts, behavior, motivation, feelings and sense of well-being, which is associated with dramatical gene expression changes in hippocampus. Rodents induced by chronic unpredictable mild stress (CUMS) demonstrate typical depression-like ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.06.001
更新日期:2020-09-01 00:00:00
abstract::We investigated whether a continuous supply of glial cell line-derived neurotrophic factor (GDNF) via encapsulated genetically modified cells can promote survival and fiber outgrowth from xenotransplanted human dopaminergic neurons. Cells genetically engineered to continuously secrete GDNF were confined in hollow fibe...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.04.009
更新日期:2005-07-30 00:00:00
abstract::Although the huge economic and social impact and the predicted incidence increase, neuroprotection for ischemic stroke remains as a therapeutically empty niche. In the present study, we investigated the rationale of the C-Phycocyanin (C-PC) treatment on global cerebral ischemia/reperfusion (I/R) injury in gerbils. We ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2011.05.016
更新日期:2011-08-10 00:00:00
abstract::Observation of people performing movements facilitates motor planning, execution and memory formation. Tempo, a crucial aspect involved in the execution of rhythmic movements, is normally perceived and learned through auditory channels. In this work, we ascertained whether: first, the frequency of self-paced finger mo...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2009.04.008
更新日期:2009-09-28 00:00:00
abstract::In pigeons, the tectofugal system is functionally as well as structurally lateralized. So for example the right nucleus rotundus is less modulated by right forebrain influences than the left nucleus rotundus by the left ones. This functional lateralization pattern may depend on a dynamic balance between left and right...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2007.10.031
更新日期:2008-03-18 00:00:00
abstract::The effects of unilateral cortical spreading depression (CSD) on feeding, drinking and other behaviors were studied in rats. CSD waves were elicited by a microinjection of KC1 solution through an implanted cannula. The animal's behavior and slow potential changes (SPC) accompanying CSD were then simultaneously monitor...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(78)90108-9
更新日期:1978-07-01 00:00:00
abstract::We examined effects of omega-conotoxin previously known as a selective blocker of N-type calcium channels, on the adenosine triphosphate (ATP)-induced currents in the rat dorsal root ganglion neurons. These neurons express at least two types of ionotropic purinoreceptors: P2X3 receptors that have very rapid desensitiz...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00433-6
更新日期:2001-03-15 00:00:00
abstract::Locomotor activity was increased as a function of current intensity in a series of rats with chronic stimulating electrodes in the tegmental pedunculopontine nucleus. Single pulse stimulation of these same mesencephalic locomotor region (MLR) sites antidromically activated more than one-quarter of the neurons sampled ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(86)90060-2
更新日期:1986-03-01 00:00:00
abstract::A computer program designed to be user friendly is described in this report. Two types of calculations are provided: a) determination of free calcium concentration based on known total salt concentration and b) those which calculate total salt concentration required to insure a desired free calcium concentration in th...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90088-f
更新日期:1992-09-01 00:00:00
abstract::Cerebral ischemic damage in gerbils was assessed by locomotor activity studies and histopathological examination of the hippocampal CA1 pyramidal cell layer. Pretreatment with AICAr (50 and 500 mg/kg) 30 min prior to a 5-min ischemic episode in unanesthetized gerbils, significantly attenuated the degree of ischemic ne...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(90)90277-7
更新日期:1990-07-01 00:00:00
abstract::To compare the developmental pattern of the visual tecto- and thalamofugal pathways in the altricial pigeon, we examined the posthatch differentiation of the retinothalamic system. Choleratoxin was injected into the left and right eye to visualize the retinal innervation pattern of the lateral geniculate nucleus of th...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2007.10.036
更新日期:2008-03-18 00:00:00
abstract::Fipronil, a GABA(A) receptor antagonist, is replacing many insecticide uses formerly fulfilled by organophosphates like chlorpyrifos. Few studies have addressed the potential for fipronil to produce developmental neurotoxicity. We compared the neurotoxicity of fipronil and chlorpyrifos in undifferentiated and differen...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.09.020
更新日期:2009-03-30 00:00:00
abstract::The vestibulo-ocular reflex (VOR) has historically been considered a computationally simple reflex: to stabilize images on the retina against imposed head rotation, the eyes must be counterrotated by an equal amount in the opposite direction. During almost any head rotation, however, the eyes are also translated. We s...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(96)00118-9
更新日期:1996-01-01 00:00:00
abstract::Thyroid hormones are essential for neonatal brain development. It is well established that absence of thyroid hormones during critical periods of development can alter sensory functions such as visual and auditory processing, but there are few studies on rat somatosensory system development at mild, long-term, and irr...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2019.11.015
更新日期:2020-02-01 00:00:00
abstract::Several hypotheses have been proposed to explain why some neurological patients fail to recognise objects from unusual views: that it results from difficulty identifying an object's principal axis when it is foreshortened, identifying an object when landmark features are occluded, or an inability to rotate mental imag...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(96)00148-7
更新日期:1996-01-01 00:00:00