Abstract：
:The interaction between nitric oxide (NO) and the release of [(3)H]noradrenaline ([(3)H]NA) in conditions of non-activated and activated nicotinic receptors in guinea-pig gastric fundus preincubated with [(3)H]NA was studied. Nicotinic receptor agonist, 1,1-dimethyl-4-phenyl-piperazinium iodide (DMPP) (100 microM) significantly increased the resting release of [(3)H]NA. NO-synthase inhibitor, N(omega)-nitro-L-arginine (L-NNA) (100 microM) significantly decreased DMPP-induced release of [(3)H]NA. Field electrical stimulation (FES) (2Hz; 1 ms; 360 st) significantly increased the release of [(3)H]NA above the basal levels. L-NNA significantly decreased the stimulation-evoked release of [(3)H]NA. DMPP increased the stimulation-evoked release of [(3)H]NA, effect which was significantly decreased by L-NNA. The data suggests that endogenous NO increases the release of [(3)H]NA, evoked either by activation of the nicotinic receptors or by electrical stimulation in guinea-pig gastric fundus.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Sotirov E,Papasova Mdoi
10.1016/s0361-9230(99)00264-6keywords:
subject
Has Abstractpub_date
2000-03-15 00:00:00pages
401-5issue
5eissn
0361-9230issn
1873-2747pii
S0361-9230(99)00264-6journal_volume
51pub_type
杂志文章abstract：:Mounting clinical and experimental evidence suggests the gut-brain interplay as a novel important paradigm in translational neuroscience, including the critical role for gut microbiota in modulating brain development and behavior, as well as neuroimmune and neuroendocrine responses. Animal models are an indispensable ...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/0361-9230(79)90014-5
更新日期：1979-11-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2007-06-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.brainresbull.2009.03.003
更新日期：2009-06-30 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90215-j
更新日期：1992-06-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2014.04.002
更新日期：2014-05-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(89)90075-0
更新日期：1989-02-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90105-7
更新日期：1992-04-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 社论
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更新日期：2016-09-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(91)90017-e
更新日期：1991-03-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.09.014
更新日期：2008-12-16 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0361-9230(02)00821-3
更新日期：2002-09-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(90)90049-6
更新日期：1990-11-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2011.07.020
更新日期：2011-10-10 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(84)90223-5
更新日期：1984-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(97)00315-8
更新日期：1998-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(89)90077-4
更新日期：1989-04-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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更新日期：2017-07-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2005.02.021
更新日期：2005-05-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(91)90255-i
更新日期：1991-06-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(91)90286-s
更新日期：1991-07-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(99)00029-5
更新日期：1999-03-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.12.009
更新日期：2009-04-06 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2020.11.019
更新日期：2021-02-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1986-10-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2012-02-10 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1981-06-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2000-07-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
abstract：:Prior results (37) showed that morphine pretreatment reduces the escape response of the crab Chasmagnathus to a shadow passing overhead and prevents the acquisition of a long-term habituation. These results were explained by a reduction in the danger signalled by the stimulus, and to test this hypothesis methods other...
journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1991-05-01 00:00:00
