Treadmill locomotion and aversive effects induced by electrical stimulation of the mesencephalic locomotor region in the rat.

Abstract:

:The effects of electrical stimulation of the "mesencephalic locomotor region" and adjacent dorsolateral tegmentum were assessed and compared in the same rats in freely moving conditions or when lightly anesthetized and suspended over a moving treadmill. In freely moving conditions, electrical brain stimulation (EBS) of this part of the mesencephalon elicited mainly aversive effects (escape reactions: violent running and explosive jumps), but also ipsiversive circling and "gnawing." On the treadmill, EBS induced flexions of hindlimbs followed by locomotion (stepping) or flexions only. In addition, it was found that locomotion and flexions on the treadmill were almost exclusively elicited by EBS of sites positive for escape reactions in freely moving conditions.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Depoortere R,Di Scala G,Sandner G

doi

10.1016/0361-9230(90)90049-6

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

723-7

issue

5

eissn

0361-9230

issn

1873-2747

pii

0361-9230(90)90049-6

journal_volume

25

pub_type

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