Abstract:
:The nucleus reticularis gigantocellularis of the rat medulla oblongata was perfused in situ, and effects of noxious stimuli on the release of immunoreactive Met-enkephalin were examined. Formalin-induced and thermal but not mechanical stimuli increased the "tonic" release of immunoreactive Met-enkephalin from this nucleus. No "phasic" increase was observed following the three forms of stimulation. A topical application of dibucaine abolished the formalin-induced increase in the release of immunoreactive Met-enkephalin. Therefore, the possibility that persistent noxious stimuli may activate the Met-enkephalin-containing fibers in the nucleus reticularis gigantocellularis has to be given consideration.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Kuraishi Y,Sugimoto M,Hamada T,Kayanoki Y,Takagi Hdoi
10.1016/0361-9230(84)90223-5subject
Has Abstractpub_date
1984-01-01 00:00:00pages
123-7issue
1eissn
0361-9230issn
1873-2747pii
0361-9230(84)90223-5journal_volume
12pub_type
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
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pub_type: 杂志文章
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