Noxious stimuli and Met-enkephalin release from nucleus reticularis gigantocellularis.

Abstract:

:The nucleus reticularis gigantocellularis of the rat medulla oblongata was perfused in situ, and effects of noxious stimuli on the release of immunoreactive Met-enkephalin were examined. Formalin-induced and thermal but not mechanical stimuli increased the "tonic" release of immunoreactive Met-enkephalin from this nucleus. No "phasic" increase was observed following the three forms of stimulation. A topical application of dibucaine abolished the formalin-induced increase in the release of immunoreactive Met-enkephalin. Therefore, the possibility that persistent noxious stimuli may activate the Met-enkephalin-containing fibers in the nucleus reticularis gigantocellularis has to be given consideration.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Kuraishi Y,Sugimoto M,Hamada T,Kayanoki Y,Takagi H

doi

10.1016/0361-9230(84)90223-5

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

123-7

issue

1

eissn

0361-9230

issn

1873-2747

pii

0361-9230(84)90223-5

journal_volume

12

pub_type

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