Abstract:
:The putative behavioral effects of the enantiomers of BAY K 8644 and the behavioral responses to (+/-)-BAY K 8644 following chronic injection were assessed on motor function in mice. The interaction of the enantiomers of BAY K 8644 with mouse brain dihydropyridine binding sites was also evaluated. The calcium channel activating enantiomer (-)-S-BAY K 8644 impaired rotarod and motor activity with an ED50 value of 0.5 mg/kg. The calcium channel blocker enantiomer (+)-R-BAY K 8644 neither affected rotarod nor motor activity. (+)-R-BAY K 8644, and the structurally related dihydropyridine calcium channel blockers nifedipine and (-)-202-791 inhibited the impairment of rotarod activity by (-)-S-BAY K 8644 in a dose-dependent manner. (+/-)-BAY K 8644 produced convulsions in mice with a CD50 of 5 mg/kg. Chronic injection of (+/-)-BAY K 8644 (8 mg/kg IP once each day for four days) resulted in a significant tolerance to, and increase in recovery from, the motor deficits produced by (+/-)-BAY K 8644. Furthermore, chronic treatment with (+/-)-BAY K 8644 increased the onset time, but did not reduce the number of mice having convulsions to (+/-)-BAY K 8644. Chronic injection of nifedipine did not affect the motor deficit and convulsive activity of (+/-)-BAY K 8644. The behavioral effects of (+/-)-BAY K 8644 were observed at significant brain levels of drug. [3H]Nitrendipine binding to mouse brain dihydropyridine binding sites was unchanged in mice chronically injected with either (+/-)-BAY K 8644 or nifedipine.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
O'Neill SK,Bolger GTdoi
10.1016/0361-9230(88)90019-6subject
Has Abstractpub_date
1988-12-01 00:00:00pages
865-72issue
6eissn
0361-9230issn
1873-2747pii
0361-9230(88)90019-6journal_volume
21pub_type
杂志文章abstract::Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, and is widely expressed in the adult mammalian brain. Besides its well known neuroprotective activity after traumatic brain injury the evidences regarding its activity dependent release by the pathophysiology of major depression ar...
journal_title:Brain research bulletin
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abstract::The effects of changes in ambient and central temperature, amines, PGEu and pyrogen were investigated with respect to the mechanism of Na+-Ca++ ratio in the posterior hypothalamus of the unrestrained cat. Guide tubes were implanted bilaterally above the posterior hypothalamic area of 23 cats so as to accommodate push-...
journal_title:Brain research bulletin
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journal_title:Brain research bulletin
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doi:10.1016/0361-9230(88)90119-0
更新日期:1988-07-01 00:00:00
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journal_title:Brain research bulletin
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pub_type: 杂志文章
doi:10.1016/0361-9230(94)90094-9
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
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更新日期:1989-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90272-l
更新日期:1991-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00523-8
更新日期:2001-07-15 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/s0361-9230(99)00242-7
更新日期:2000-01-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:2002-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90034-5
更新日期:1994-01-01 00:00:00
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更新日期:2020-04-01 00:00:00
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doi:10.1016/j.brainresbull.2007.07.006
更新日期:2007-10-19 00:00:00
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pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
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更新日期:2013-08-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90275-o
更新日期:1991-07-01 00:00:00
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journal_title:Brain research bulletin
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doi:10.1016/j.brainresbull.2011.05.013
更新日期:2011-08-10 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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