Abstract：
:Progressive disruption of both the neuroendocrine and immune systems has been correlated with age-associated pathogenesis in patients with Alzheimer's disease and in mice lacking apolipoprotein E (ApoE). In this study, we examined neuroautoimmune and neuroendocrine activities in relation to aging and stress in ApoE-deficient mice. An elevated level of autoantibodies against brain antigens was found in sera from ApoE-deficient mice compared to that of wild-type mice as early as 7-8 weeks of age. However, there was no significant difference between the two genotypes at this age in the effect of stress on serum corticosterone or autoantibody titers. Higher titers of autoantibodies were observed in approximately 12-week-old ApoE-deficient mice, especially in those exposed to chronic stress. Based on Western analysis, sera from ApoE-deficient mice showed a strong immunoreactivity with approximately 78 kDa and approximately 40 kDa brain abundant polypeptides, approximately 58 kDa non-brain tissue abundant antigen, and others of approximately, 80-82 kDa in both the brain and non-brain tissues. Immunofluorescence confocal microscopy showed that the major cellular components recognized by the autoimmune sera from ApoE-deficient mice were associated with neuronal cell nuclei and fiber-like structures in different regions of the brain, including the frontal cortex, lateral cortex and hippocampus. These results suggest that neuroautoimmunity associated with the aging process and exposure to chronic stress may be involved in early development of neurodegeneration in mice with ApoE-deficiency.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Zhou Y,Cheshire A,Howell LA,Ryan DH,Harris RBdoi
10.1016/s0361-9230(99)00052-0keywords:
subject
Has Abstractpub_date
1999-06-01 00:00:00pages
173-9issue
3eissn
0361-9230issn
1873-2747pii
S0361-9230(99)00052-0journal_volume
49pub_type
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journal_title：Brain research bulletin
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journal_title：Brain research bulletin
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journal_title：Brain research bulletin
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1987-05-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Brain research bulletin
pub_type： 杂志文章
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pub_type： 杂志文章
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doi：10.1016/j.brainresbull.2020.10.008
更新日期：2020-12-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(01)00760-2
更新日期：2002-03-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.10.011
更新日期：2005-12-15 00:00:00
abstract：:A substantial and still growing body of research tries to link different psychological models and chronic diseases, with special emphasis on cardiovascular disease. These efforts have established several conceptual bridges that connect psychological alterations and psychosocial factors to the risks, onset and prognosi...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2003.12.001
更新日期：2004-02-01 00:00:00
