当前位置： SCI文献检索 > BRAIN RESEARCH BULLETIN期刊下所有文献 > In vivo modulation of follicle-stimulating hormone release and beta subunit gene expression by activin A and the GnRH agonist buserelin in female rats.

In vivo modulation of follicle-stimulating hormone release and beta subunit gene expression by activin A and the GnRH agonist buserelin in female rats.

Abstract：

:The effects of separate and simultaneous recombinant bovine (rb) activin A and buserelin administration on the FSH release and pituitary FSH beta subunit gene expression in vivo were examined in ovariectomised, estradiol pretreated rats. The animals received a single injection of either rb activin A (50 ng), buserelin (1 micro g) or activin/buserelin (50 ng+1 micro g/0.1 ml PBS) into the jugular vein and were killed 30 min, 1, 3 and 5h later. Activin A stimulated FSH release and effect appeared 1h after injection (168% increase of controls) reaching a maximum at 3h (437% of controls). Activin A and buserelin exerted their effects with a distinct time courses: activin's stimulation was not so rapid when compared with buserelin. The simultaneous administration of rb activin A and buserelin amplified FSH release (118, 309, 1006 and 779% of controls). The low dose of activin A was sufficient to elevate FSH beta mRNA level as early as 3 and 5h after administration (170 and 140%, respectively). Activin plus buserelin stimulation resulted in a higher (340 and 360% of controls) FSH beta gene expression than after their separate administration. These results suggest that activin and buserelin may act independently and synergistically in the regulation of FSH release and beta subunit mRNA level.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Gajewska A,Siawrys G,Bogacka I,Przala J,Lerrant Y,Counis R,Kochman K

doi

10.1016/s0361-9230(02)00821-3

keywords:

subject

Has Abstract

pub_date

2002-09-15 00:00:00

pages

475-80

issue

5

eissn

0361-9230

issn

1873-2747

pii

S0361923002008213

journal_volume

58

pub_type

杂志文章

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