Abstract:
:Degenerating terminals were mapped by the Fink-Heimer method after lateral or fourth ventricular administration of 6-hydroxydopamine (60OHDA). This method marks dopaminergic terminals and has the advantage that noradrenergic terminals are not stained. Fink-Heimer stained degeneratig terminals were seen bilaterally in specific patterns in many nuclei known to have a dopaminergic innervation: neostriatum, nucleus accumbens, olfactory tubercle, the dorsolateral and ventral parts of the bed nucleus of the stria terminalis, laterla septal nucleus, amygdala, and layers II-III of anterior cingulate cortex. Detailed maps are provided of the dopaminergic innervation in the bed nucleus of the atria terminalis in relatin to the cytoarchitectural subdivisions of this nucleus. A Fink-Heimer stained field was discovered in the lateral parabrachial nucleus, suggesting the presence of a previously unreported dopaminergic innervation of this nucleus. It was also noted that nonspecific degeneration near the injection site was much worse after lateral ventricle than after fourth ventricle injection.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Hedreen Jdoi
10.1016/s0361-9230(80)80013-xsubject
Has Abstractpub_date
1980-07-01 00:00:00pages
425-36issue
4eissn
0361-9230issn
1873-2747pii
S0361-9230(80)80013-Xjournal_volume
5pub_type
杂志文章abstract::Sleep EEG in the sigma and delta frequency bands was subjected to spectral analysis in 8 normal young adults. In each subject, power density of sigma and delta oscillated reciprocally during NREM sleep, confirming an observation made initially with period/amplitude analysis. In REM sleep, power density for both freque...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90286-s
更新日期:1991-07-01 00:00:00
abstract::Aβ plaques of Alzheimer's disease (AD) are believed to precede cognitive deficits or clinical manifestation by decades. However, validated biomarkers for early diagnosis of the AD disease are still not available. In this present study, we combined MRI-based neuroimages and histological assessment of the glial response...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.01.003
更新日期:2020-03-01 00:00:00
abstract::Astrocytes become activated and proliferate in response to autoimmune diseases involving the CNS. In many cases, elevated numbers of astrocytes may compound inflammatory responses and exacerbate neuronal degeneration. The regulation of astrocytes in disease states has been shown as an important corollary to disease pr...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2012.09.001
更新日期:2013-01-01 00:00:00
abstract::The topographical distribution of glutamate uptake, GABA uptake, and GAD activity was studied in caudal, intermediate and rostral areas of the nucleus of the solitary tract (NTS), dorsal motor nucleus of the vagus (DMN) and the of the solitary tract (NTS), dorsal motor nucleus of the vagus (DMN) and the hypoglossal nu...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(85)90176-5
更新日期:1985-01-01 00:00:00
abstract::Our previous results showed that neurochemical destruction of the amygdaloid terminal field of the mesolimbic dopaminergic system caused disturbances in body weight regulation and feeding. In the present experiments, it was studied whether 6-hydroxydopamine (6-OHDA)-induced bilateral lesions of the mesolimbic dopamine...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90125-4
更新日期:1991-09-01 00:00:00
abstract::Prenatal exposure of mice to heroin (SC injection of 10mg/kg to the dams on gestational days 9-18) resulted at adulthood in behavioral deficits related to septohippocampal cholinergic innervation accompanied with both presynaptic and postsynaptic cholinergic hyperactivity; including an increase membrane PKC activity, ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2004.04.006
更新日期:2004-05-30 00:00:00
abstract::Central cholinergic neurons play an important role in learning and memory functions. The present study was undertaken to elucidate the pathological changes in learning function and acetylcholine metabolism of the cerebral cortex and hippocampus, following microsphere embolism in rats. Microspheres (48 microns) were in...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(96)00350-4
更新日期:1997-01-01 00:00:00
abstract::In the preceding article, a dorsochiasmatic area (DCh) was described that projects to both paraventricular (PVN) and supraoptic (SON) nuclei. The main afferents of the DCh, revealed by local injections of retrograde tracers, are the hypothalamic PVN and SON, lateral septal nuclei (LSV and SHy), bed nuclei of the stria...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90107-4
更新日期:1994-01-01 00:00:00
abstract::Morphine exposure may have a negative effect on the receptive field properties of neurons in primary visual cortex of cats. The present experiment used morphological methods in order to investigate whether chronic morphine treatment also affects dendritic characters of these neurons. According to the Sholl analysis an...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.06.007
更新日期:2008-09-30 00:00:00
abstract::Chronic swimming training and phytotherapeutic supplementation are assumed to alleviate oxidative damage, and support cell survival in the brain. The effect of forced, chronic swimming training, and enriched lab chow containing 1% (w/w) dried nettle (Urtica dioica) leaf were investigated for oxidative stress, inflamma...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.02.028
更新日期:2005-05-30 00:00:00
abstract::The caudal neurosecretory system of Poecilia sphenops (molly) is an isolated population of neurosecretory cells located in the caudal most aspect of the teleost spinal cord. The structure of this neuroendocrine system is favorable for studies on the synaptic control of neurosecretory mechanisms. Little is known about ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90079-5
更新日期:1983-01-01 00:00:00
abstract::Somatosensory input to 431 neurons in MsI has been studied in unanesthetized, paralyzed raccoons (Procyon lotor). The type of sensory input to neurons in lateral sigmoid gyrus (cytoarchitectonic area 4) and in posterior sigmoid gyrus (areas 4 and 3a) was not significantly different. Of these neurons, 36% were activate...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(90)90146-q
更新日期:1990-06-01 00:00:00
abstract::Plasma gonadotropins, prolactin and hypothalamic tyrosine hydroxylase (TH) activity were evaluated at 15 and 30 min after third ventricular injection of bombesin at doses of 100 or 1000 ng and secretin at doses of 1000 and 5000 ng in ovariectomized (OVX) unanesthetized rats. Bombesin had no effect on plasma gonadotrop...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90053-9
更新日期:1983-07-01 00:00:00
abstract::In this study, we compared the depression-like symptoms induced by olfactory bulbectomy (OBX) in the two inbred Wistar and Long Evans rat strains. We also analyzed the self-regulated oral intake of nicotine in these strains and the effect of nicotine on the depression-like symptoms of olfactory bulbectomy. Furthermore...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.05.007
更新日期:2008-09-05 00:00:00
abstract::The projections from the rat medial prefrontal cortex to the amygdaloid complex were investigated using retrograde transport of fluorescent dyes and anterograde transport of horseradish peroxidase-WGA. The ventral anterior cingulate, prelimbic, infralimbic and medial orbital areas and the taenia tecta were found to pr...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(86)90237-6
更新日期:1986-09-01 00:00:00
abstract::Bilateral lesions of the entorhinal cortex (E.C.) of the rat result in persistent deficits in both spontaneous and reinforced alternation. The present study analyzes the nature of this impairment. To determine if changes in exploratory activity accompanied the deficits in alternation, open field activity was measured ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(77)90023-5
更新日期:1977-01-01 00:00:00
abstract::In brainstem slices of male rats, we examined in single neurons of the medial vestibular nucleus (MVN) the effect of exogenous administration of estrogenic (17β-estradiol, E2) and androgenic (5α-dihydrotestosterone, DHT) steroids on the synaptic response to vestibular afferent stimulation. By whole cell patch clamp re...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2013.05.006
更新日期:2013-08-01 00:00:00
abstract::Results using radial mazes suggest rats may have a greater short-term memory (STM) capacity than the human "magical number seven." We examined spatial STM in humans using a radial maze analog drawn on paper. Subjects were instructed to lift, in "random" order, each of 17 cardboard flaps arranged radially around a cent...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90058-j
更新日期:1993-01-01 00:00:00
abstract::In humans, perturbations in the developmental neuronal death leading to an excess of neurons could be associated with developmental neuropsychiatric disorders. Hu-bcl-2 transgenic mice appear to be a valuable tool to study the functional role of developmental programmed cell death. Indeed, the over-expression of the a...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00639-6
更新日期:2002-01-01 00:00:00
abstract::Creatine kinase reaction rates were measured by the magnetisation transfer technique in brains of healthy adult and aged rats and in rats with chronic cerebral ischemia and chronic ethanol intoxication. These measurements indicated that the rate constant of the creatine kinase reaction is significantly reduced in the ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(00)00405-6
更新日期:2000-11-01 00:00:00
abstract::Specific angiotensin II (Ang II) binding sites are present in the dorsal medulla of several species, and dose-related cardiovascular effects are produced by microinjection of the peptide into this region. Because the anatomical location of Ang II binding sites in the area postrema (ap), nucleus tractus solitarii (nTS)...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(86)90217-0
更新日期:1986-10-01 00:00:00
abstract::Developmental changes in the control of neurite extension by extracellular factors can be examined by utilizing cultures of neurons from various aged embryos. Several conditioned media and tissue extracts were added to cultures of chick embryo retinal neurons on collagen substrates for 1, 3 and 5 days in vitro. Neurit...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(87)90112-2
更新日期:1987-04-01 00:00:00
abstract::Nine healthy subjects standing upright, initiated small, medium and large (S, M and L conditions, respectively) forward movements of their right (Rt) arm together with backward movements of their left (Lt) arm. They also performed medium-size movements while holding a 3 kg dumbbell in each hand (D condition). Movement...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.05.015
更新日期:2005-09-30 00:00:00
abstract::Entrainment of the dominant circadian pacemaker localised to the hypothalamic suprachiasmatic nuclei (SCN) is mediated partially via the indirect retino-geniculo-hypothalamic projection to the SCN, which is presumed to utilise enkephalin and other neurotransmitters, to modulate circadian rhythmicity. In the present st...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(99)00069-6
更新日期:1999-09-15 00:00:00
abstract::Crested Ducks (CR) occasionally show intracranial fat bodies. Additionally, behavioral abnormalities such as motor incoordination can be observed. Here, it is shown that a behavioral test helps to identify CR that have a problematical fat body. The ducks were put on their backs, and the time required for them to stand...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.03.009
更新日期:2008-06-15 00:00:00
abstract::The distribution of calcitonin gene-related peptide (CGRP)-like immunoreactive (LI) nerve cells and terminals (BST) was studied in the rat. Only the fusiform nucleus was found to consistently contain CGRP-LI neurons. The CRGP-LI terminals had a wide distribution in the BST, being most numerous in the oval and the fusi...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90036-j
更新日期:1991-11-01 00:00:00
abstract::Investigation of the differentiation of electrical properties of motoneurons has been stimulated by the importance of these neurons for embryonic behavior and facilitated by their experimental accessibility. In this review, we examine the development of different patterns of excitability and their functions, and discu...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/s0361-9230(00)00388-9
更新日期:2000-11-15 00:00:00
abstract::This paper surveys more than twenty types of tactile illusions and discusses several of their aspects. These aspects include the ease with which they can be demonstrated and whether they have clear visual analogs. The paper also shows how to construct equipment made of simple supplies able to deliver well-controlled t...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2008.01.008
更新日期:2008-04-15 00:00:00
abstract::To better describe the hypothalamic efferents that mediate estrogenic effects on lordosis, each of 18 ovariectomized hamsters received a 30 gauge implant of estradiol aimed at the right or left ventromedial hypothalamus (VMN). Six days later, subjects were treated with progesterone and observed for their durations of ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(89)90094-4
更新日期:1989-04-01 00:00:00
abstract::Emerging evidence suggests that sleep deprivation (SD) is a public health epidemic and increase the risk of Alzheimer's disease (AD) progression. However, the underlying mechanisms remain to be fully investigated. In this study, we investigate the impact of 72 h SD on the prefrontal cortex (PFC) of 3∼4-months-old APP/...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.11.003
更新日期:2021-01-01 00:00:00