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To die or not to die, does it change the function? Behavior of transgenic mice reveals a role for developmental cell death.

Abstract：

:In humans, perturbations in the developmental neuronal death leading to an excess of neurons could be associated with developmental neuropsychiatric disorders. Hu-bcl-2 transgenic mice appear to be a valuable tool to study the functional role of developmental programmed cell death. Indeed, the over-expression of the anti-apoptotic gene bcl-2 decreases developmental neuronal death and Hu-bcl-2 mice present supernumerary neurons in several brain regions. A detailed behavioral analysis of these mice revealed selective deficits. Hu-bcl-2 mice have normal vision, general activity and motor skills. Only the most complex behavior like anxiety and learning abilities are impaired in these mice.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Rondi-Reig L,Mariani J

doi

10.1016/s0361-9230(01)00639-6

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

85-91

issue

1

eissn

0361-9230

issn

1873-2747

pii

S0361923001006396

journal_volume

57

pub_type

杂志文章

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