Abstract:
:Maternal immune activation during pregnancy is a risk factor for neurodevelopmental disorders, such as schizophrenia; however, a full mechanistic understanding has yet to be established. The activity of a transient cell population, the subplate neurons, is critical for the development of cortical inhibition and functional thalamocortical connections. Sensitivity of these cells to factors released during inflammation, therefore, may offer a link between maternal immune activation and the aberrant cortical development underlying some neuropsychiatric disorders. An elevated extracellular ATP concentration is associated with inflammation and has been shown to have an effect on neuronal activity. Here, we investigated the effect of ATP on the electrophysiological properties of subplate neurons. Exogenous ATP increased the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs) at micromolar concentrations. Further, ATP released by astrocytes activated by the PAR-1 agonist, TFLLR-NH2, also increased the amplitude and frequency of sEPSCs in subplate neurons. The electrophysiological properties of subplate neurons recorded from prefrontal cortical (PFC) slices from neonatal rats were also disrupted in a maternal immune activation rat model of schizophrenia, with a suramin-sensitive increase in frequency and amplitude of sEPSCs. An alternative neurodevelopmental rat model of schizophrenia, MAM-E17, which did not rely on maternal immune activation, however, showed no change in subplate neuron activity. Both models were validated with behavioral assays, showing schizophrenia-like endophenotypes in young adulthood. The purinergic modulation of subplate neuron activity offers a potential explanatory link between maternal immune activation and disruptions in cortical development that lead to the emergence of neuropsychiatric disorders.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Beamer E,Kovács G,Sperlágh Bdoi
10.1016/j.brainresbull.2017.10.006subject
Has Abstractpub_date
2017-10-01 00:00:00pages
129-142eissn
0361-9230issn
1873-2747pii
S0361-9230(17)30379-9journal_volume
135pub_type
杂志文章abstract::Data from clinical investigations and laboratory fundings have provided preliminary evidence for the effectiveness and safety of acupuncture therapy in depression. However, the mechanisms underlying the antidepressant response of acupuncture are not fully elucidated. To elucidate the potential effects of acupuncture f...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2017.07.021
更新日期:2017-09-01 00:00:00
abstract::The involvement of alpha-amino-3-hydroxy-5-methylizoxazole-4-propionic acid (AMPA) receptors in induction of long-term potentiation (LTP) was examined in rat hippocampal slice preparation. Using conventional extracellular recording, excitatory postsynaptic potentials (EPSPs) and population action potentials (PSs), evo...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(00)00288-4
更新日期:2000-08-01 00:00:00
abstract::All mammals have complex behaviours but these are generally stereotyped in nature and lack the flexibility of human behaviour. Can the flexibility of human behaviour be understood as an evolutionary extension of previous behaviours or is it a departure? Theories pertaining to this question have a long history includin...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2007.06.008
更新日期:2007-09-28 00:00:00
abstract::Songbirds have emerged as extremely important animals for investigating sex steroid hormone effects on the central nervous system. The masculinizing effects of exogenous estrogen on the neural circuits controlling song in female zebra finches are well documented. There is evidence that estrogens are necessary for the ...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/s0361-9230(97)00215-3
更新日期:1997-01-01 00:00:00
abstract::miR-196a is located in the posterior trunk and plays a role in limb development. Here we show that miR-196a is able to induce eye anomaly in Xenopus laevis. Microinjection of synthetic miRNA precursor molecule for mammalian miR-196a into Xenopus embryo is sufficient for miR-196a overexpression during early development...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.12.009
更新日期:2009-04-06 00:00:00
abstract::Neonatal post-hemorrhagic hydrocephalus is associated with cognitive decline and a serious deterioration in the patient's quality of life. The underlying impairments to neurons are not well understood. Here, we used the method described by Cherian et al. to construct a model of hydrocephalus after intra-ventricular he...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2010.06.009
更新日期:2010-08-30 00:00:00
abstract::Ethanol has a pharmacological profile similar to other centrally acting drugs, which facilitate GABAergic transmission. GABA is known to produce its effects by increasing the conductance to Cl- ions. In this study, we have examined the effect of ethanol on GABA-induced 36Cl-influx in primary spinal cord cultured neuro...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(86)90168-1
更新日期:1986-07-01 00:00:00
abstract::Progressive disruption of both the neuroendocrine and immune systems has been correlated with age-associated pathogenesis in patients with Alzheimer's disease and in mice lacking apolipoprotein E (ApoE). In this study, we examined neuroautoimmune and neuroendocrine activities in relation to aging and stress in ApoE-de...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(99)00052-0
更新日期:1999-06-01 00:00:00
abstract::Expression of the Huntington's disease (HD) mutation in mice (R6/2 line) causes a progressive neurological phenotype that includes deterioration of motor function resembling that seen in HD. The current study sought to determine whether or not chronic treatment of R6/2 mice with lithium chloride would have an effect o...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(03)00141-2
更新日期:2003-08-30 00:00:00
abstract::Fourteen patients with high- (n = 7) and low-dose (n = 7) benzodiazepine (BDZ) dependency presented predominantly with anxious and depressive neurotic symptoms which caused long-term BDZ medication. Their BDZ dependency was characterized by giving preference to the abuse of benzodiazepines with long elimination half-l...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(87)90109-2
更新日期:1987-09-01 00:00:00
abstract::The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is involved in several morphogenetic processes of the central nervous system. In the present study the expression of PSA-NCAM has been investigated in the rat thalamus during embryonic and postnatal development using light and electron microscopic...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2006.11.015
更新日期:2007-03-30 00:00:00
abstract::Neurodevelopmental disorders such as autism and schizophrenia involve social interaction problems and poor mentalizing abilities, associated with abnormal regional cerebral activity. Similar problems may be present in aggressive personality disorders and psychopathy. This paper reviews brain imaging data from research...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2006.01.008
更新日期:2006-04-14 00:00:00
abstract::To examine synaptic input and association of terminals containing dopamine and other transmitters to rat striatal nitric oxide synthase-expressing neurons, an electron microscopic study using tyrosine hydroxylase (TH) immunohistochemistry combined with histochemistry for NADPH-diaphorase (NADPHd) was performed. NADPHd...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(96)00035-4
更新日期:1996-01-01 00:00:00
abstract::As human brain development proceeds, there are complex changes in size and shape, most notably in the developing forebrain. Molecular technologies enable us to characterise the gene expression patterns that underlie these changes. To interpret these patterns the location of expression must be identified and, often, ge...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.05.022
更新日期:2005-09-15 00:00:00
abstract::Hoe 065 is a compound structurally related to the angiotensin converting enzyme inhibitors and capable of increasing central cholinergic activity. The effects of this compound were studied on alcohol intake and on the reduction in alcohol intake produced by abutapril, an angiotensin converting enzyme inhibitor. Hoe 06...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90104-r
更新日期:1991-04-01 00:00:00
abstract::We propose that separate sensory and hedonic representations exist in each of the primary structures of the somatosensory system, including brainstem, thalamic and cortical components. In the dorsal horn of the spinal cord, the hedonic representation, which consists primarily of nociceptive-specific, wide dynamic rang...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/s0361-9230(02)00783-9
更新日期:2002-07-01 00:00:00
abstract::The issue of possible neurobiological effects of the electromagnetic field (EMF) exposure is highly controversial. To determine whether electromagnetic field exposure could act as an environmental stimulus capable of producing stress responses, we employed the hippocampus, a sensitive target of electromagnetic radiati...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2012.04.002
更新日期:2012-07-01 00:00:00
abstract::It has been demonstrated that the posteromedial cortical amygdaloid nucleus (PMCo), is sexually dimorphic. It is shown (Experiment 1) that male orchidectomy on the day of birth (D1) decreases the volume and number of neurons of the PMCo, while a single injection of propionate testosterone to the female on D1 masculini...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(00)00332-4
更新日期:2000-10-01 00:00:00
abstract::Ongoing maternal behavior in rats is under the inhibitory influence of opiates. Exposure to drugs of abuse may result in a progressive and enduring enhancement of their reinforcing effects. Little attention has been paid to the possibility that puerperal treatment with morphine may lead to sensitization to this drug, ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00549-4
更新日期:2001-07-01 00:00:00
abstract::The effects of a unilateral lesion made on the right or left side of the preoptic area (POA) or anterior hypothalamic area (AHA) made on each day of the estrous cycle, were analyzed. Ovulation rate decreased among the animals with a lesion performed on the day of estrous on the right side of POA (1/7 vs. 7/7, p < 0.05...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90230-5
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Deep brain stimulation (DBS) refers to the delivery of electric current to specific deep brain structures through implanted electrodes. Recently approved for use in United States, DBS to the anterior nucleus of thalamus (ANT) is a safe and effective alternative treatment for medically refractory seizures. De...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2019.01.011
更新日期:2019-04-01 00:00:00
abstract::A comparative study of the distribution of substance P (SP) and enkephalin (ENK) immunoreactivity in the substantia nigra (SN) of the rat, cat and squirrel monkey (Saimiri sciureus) was undertaken by means of the indirect immunofluorescence technique. In the rat a dense neuronal network composed of fine fibers display...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90133-3
更新日期:1984-08-01 00:00:00
abstract::Stimulus-specific neuronal responses in the central auditory pathway of Psammomys obesus were studied with deoxyglucose autoradiography. Responses were revealed mainly in the inferior colliculus. With whole head sectioning and subsequent gentle freeze-drying, excellent structural preservation was achieved. With the us...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90061-3
更新日期:1984-03-01 00:00:00
abstract::High dietary salt intake activates the brain renin-angiotensin system in spontaneously hypertensive rats (SHR) and Dahl S rats, resulting in sympathetic hyperactivity and hypertension. Increases of sodium concentration in cerebrospinal fluid (CSF) and/or enhanced responses to CSF sodium are considered to be involved i...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.09.004
更新日期:2006-01-30 00:00:00
abstract::A classical approach to the control of food consumption has been to assume separate mechanisms for the arousal to eat, on the one hand, and the satiation of feeding responses, on the other. The present paper is concerned with a single, and a comparatively simple, neuronal mechanism which is endowed with properties to ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(85)90008-5
更新日期:1985-10-01 00:00:00
abstract::Sleep EEG in the sigma and delta frequency bands was subjected to spectral analysis in 8 normal young adults. In each subject, power density of sigma and delta oscillated reciprocally during NREM sleep, confirming an observation made initially with period/amplitude analysis. In REM sleep, power density for both freque...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90286-s
更新日期:1991-07-01 00:00:00
abstract::In previous studies we have demonstrated that spinal motoneurons in the adult cat can regenerate CNS-type axons through CNS scar tissue into denervated ventral roots. This scar tissue, which appears to support and sustain the growth of injured CNS axons, has been shown to have a persistent defect in the blood-brain ba...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90272-d
更新日期:1993-01-01 00:00:00
abstract::Impairment of endosomal/lysosomal functions are reported as some of the earliest changes in several age-related neurological disorders such as Alzheimer's disease. Dysregulation of the lysosomal system is also accompanied by the accumulation of age-associated pigments and several recent reports have indicated that thi...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(02)00948-6
更新日期:2003-02-15 00:00:00
abstract::A focus of epileptiform discharge was induced in rat isocortex by subpial injection of 5 microliters of 100 mM FeCl3. Control animals were prepared with saline injections. Protein synthesis was estimated by uptake of [3H]lysine and its incorporation into protein at the site of iron injection, in the contralateral homo...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(81)80019-6
更新日期:1981-06-01 00:00:00
abstract::Neuropathic pain (NP) is a challenge due to our limited understanding of the mechanisms that initiate and maintain chronic pain. The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is an important area of the emotional and cognitive components of pain and pharmacological systems can interact into the n...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.09.013
更新日期:2020-12-01 00:00:00