Abstract:
:Ethanol has a pharmacological profile similar to other centrally acting drugs, which facilitate GABAergic transmission. GABA is known to produce its effects by increasing the conductance to Cl- ions. In this study, we have examined the effect of ethanol on GABA-induced 36Cl-influx in primary spinal cord cultured neurons. GABA produces a concentration-dependent, and saturable effect on 36Cl-influx in these neurons. Ethanol potentiates the effect of GABA on 36Cl-influx in these neurons. GABA (20 microM) increased the 36Cl-influx by 75% over the basal value, and in the presence of 50 mM ethanol, the observed increase was 142%. Eadie-Hoffstee analysis of the saturation curves indicated that ethanol decreases the Km value of GABA (10.6 microM to 4.2 microM), and also increases the Vmax. Besides potentiating the effect of GABA, ethanol also appears to have a direct effect in the absence of added GABA. These results suggest that ethanol enhances GABA-induced 36Cl-influx and indicate a role of GABAergic system in the actions of ethanol. These results also support the behavioral and electrophysiological studies, which have implicated GABA systems in the actions of ethanol. The potential mechanism(s) and the role of direct effect of ethanol is not clear at this time, but is currently being investigated.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Ticku MK,Lowrimore P,Lehoullier Pdoi
10.1016/0361-9230(86)90168-1subject
Has Abstractpub_date
1986-07-01 00:00:00pages
123-6issue
1eissn
0361-9230issn
1873-2747pii
0361-9230(86)90168-1journal_volume
17pub_type
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.03.009
更新日期:2008-06-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2004.06.002
更新日期:2004-08-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2014.06.001
更新日期:2014-08-01 00:00:00
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
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doi:10.1016/j.brainresbull.2014.01.005
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pub_type: 杂志文章
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更新日期:2009-04-29 00:00:00
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pub_type: 杂志文章
doi:10.1016/0361-9230(90)90277-7
更新日期:1990-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2015.11.004
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1987-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2001-05-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(77)90038-7
更新日期:1977-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.12.013
更新日期:2009-04-06 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2018.08.008
更新日期:2018-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1990-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.06.018
更新日期:2005-09-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90222-5
更新日期:1988-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2018.12.005
更新日期:2019-03-01 00:00:00