Abstract:
:Excised lateral eye retinular cells of Limulus polyphemus exposed to chlorobutanol were examined using microelectrode techniques. The effects observed were: (1) a marked shortening of the receptor potential latent period; (2) a decrease in the effective input resistance of retinular cells to hyperpolariziog currents; and (3) a reduction in magnitude of retinular cell receptor and membrane potential. The magnitude of the changes were concentration dependent and reversible and were only produced by chlorobutanol and closely related compounds. Chlorobutanol does not alter the sodium permeability of the receptor cell membrane but it may increase the rate of the process or processes occurring during the latent period of the receptor potential.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Wulff VJ,Jahy JLdoi
10.1016/0361-9230(77)90038-7subject
Has Abstractpub_date
1977-05-01 00:00:00pages
197-202issue
3eissn
0361-9230issn
1873-2747pii
0361-9230(77)90038-7journal_volume
2pub_type
杂志文章abstract::Diminished sensitivity to kainic acid (KA) lesioning action is present in the hippocampus of the lactating dam. Given that KA can alter blood-brain barrier (BBB) permeability, we investigated whether lactation would protect BBB permeability after treatment with this neurotoxin. Adult virgin or lactating (13-15 days pp...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2018.11.020
更新日期:2019-01-01 00:00:00
abstract::Vesicular glutamate transporter (VGLUT) 1 and VGLUT2 have been reported to distribute complementally in most brain regions and have been assumed to define distinct functional elements. Previous studies have shown the expression of VGLUT1 mRNA and VGLUT2 mRNA in the lateral reticular nucleus (LRN), a key precerebellar ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.06.008
更新日期:2020-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(99)00052-0
更新日期:1999-06-01 00:00:00
abstract::The present study was conducted to examine the effects of d-amphetamine and the designer drugs 3,4-methylenedioxymethamphetamine (MDMA), N-methyl-3,4-methylenedioxyphenyl-3-butamine (HMDMA), 3,4-methylenedioxyphenyl-2-butanamine (BDB), 3,4-methylenedioxyphenyl-1-ethanamine (MDM1EA) in the chick embryo and the young ch...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90011-6
更新日期:1994-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(96)00256-0
更新日期:1997-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(98)00147-6
更新日期:1999-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(89)90057-9
更新日期:1989-02-01 00:00:00
abstract::The uptake of 3H-2-deoxyglucose (3H-2-DG) in selected brain structures was determined subsequent to electrical stimulation of insular cortex (Ins) and the mediodorsal (MD) nucleus of the thalamus in rabbits. Stimulation of Ins elicited parasympathetic-like responding (i.e., bradycardia and depressor responses); wherea...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(87)90148-1
更新日期:1987-10-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90202-x
更新日期:1994-01-01 00:00:00
abstract::Developing animals are more sensitive than adults to the delayed neurotoxicity caused by chlorpyrifos exposure. In developing rat brain, chlorpyrifos doses that cause no discernible systemic toxicity and only a minor degree of cholinesterase inhibition, nevertheless evoke alterations in cell function and number that a...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(97)00329-8
更新日期:1998-01-01 00:00:00
abstract::Normal human subjects made rapid extensions of the elbow from an initial position to visual targets at different angular distances (9 degrees-54 degrees). We recorded joint angle, acceleration, and surface electromyograms (EMGs) with a monopolar electrode from the triceps and the biceps brachii muscles. Both the agoni...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90034-9
更新日期:1993-01-01 00:00:00
abstract::Prenatal exposure of mice to heroin (SC injection of 10mg/kg to the dams on gestational days 9-18) resulted at adulthood in behavioral deficits related to septohippocampal cholinergic innervation accompanied with both presynaptic and postsynaptic cholinergic hyperactivity; including an increase membrane PKC activity, ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2004.04.006
更新日期:2004-05-30 00:00:00
abstract::Induction of expression of immediate-early gene c-Fos in the striatum is a common effect of many drugs of abuse, including morphine. Previous studies have shown that the morphine-mediated c-Fos response is attenuated by antagonists of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. Other evidence sugges...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(00)00451-2
更新日期:2001-01-15 00:00:00
abstract::Psychoactive drug use occurs in essentially all human societies. A range of disciplines contribute to our understanding of the influence of drugs upon the human world. For example pharmacology and neuroscience analyse biological responses to drugs, sociology examines social influences upon people's decisions to use dr...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2016.04.008
更新日期:2016-09-01 00:00:00
abstract::The influence on pain processing caused by destruction or stimulation of the dorsal reticular nucleus (DRt) was studied using the tail-flick and the increasing temperature hot-plate tests. Lesions of the DRt were obtained by injecting quinolinic acid (180 nmol/microliters) unilaterally or bilaterally, and nociceptive ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(95)02027-6
更新日期:1996-01-01 00:00:00
abstract::On the basis of the evidence that approximately 45% of Schaffer collateral boutons are zinc-positive, zinc release from Schaffer collaterals and its action were examined in hippocampal slices. When zinc release from Schaffer collaterals was examined using ZnAF-2, a membrane-impermeable zinc indicator, ZnAF-2 signal in...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.10.001
更新日期:2006-02-15 00:00:00
abstract::The suprachiasmatic nucleus (SCN) receives a direct retinal projection, which in rats includes substance P (SP)-immunoreactive retinal ganglion cells. While SP has been shown to have neurophysiological effects on SCN cells in Syrian hamsters and rats, it is not known what effects SP in the SCN has on circadian rhythms...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(96)00371-1
更新日期:1997-01-01 00:00:00
abstract::Our previous in vivo structure-activity studies suggested that the putative receptors mediating the effects of NPY and NPY2-36 on food intake and body temperature are pharmacologically different [17]. In the present study, we examined and compared dose-related effects of NPY and NPY2-36 on ad lib food intake and recta...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)00177-3
更新日期:1995-01-01 00:00:00
abstract::Although iron is involved in brain function, very little is known about the regulation of its concentrations in the central nervous system. We quantitatively measured the entry and exit rates of iron, transferrin (its major transport protein), and albumin in mice. The blood to brain transport of iron greater than tran...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90021-4
更新日期:1988-12-01 00:00:00
abstract::The development of the lateral, basomedial and basolateral nuclei of the amygdala in 1-28 day old kittens was studied using Golgi morphometric methods. The major finding of this study is the growth of neurons within each of the nuclei of the amygdala examined occurs during the same time period, between 5-14 and 16-18 ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(85)90075-9
更新日期:1985-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2010.04.018
更新日期:2010-10-30 00:00:00
abstract::Calcitonin, a peptide hormone expressed in C-cells of the thyreoid gland, as well as capsaicin, isolated from chili, both, modify intracellular signalling in nociceptive neurones. The pathways triggered by the activation of either of these receptors results in a modulation of the intracellular calcium ([Ca(2+)](i)) co...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2011.02.006
更新日期:2011-04-25 00:00:00
abstract::The effect of endocannabinoids on synaptic plasticity has been demonstrated in a variety of species and brain regions. Relatively little is known about the localization and significance of cannabinoid (CB) receptors in the avian brain. The objective of the present study was to investigate the effect of a specific CB(1...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.02.004
更新日期:2008-06-15 00:00:00
abstract::Corticotropin-releasing factor (CRF) is the major neuromodulator of the hypothalamic-pituitary-adrenal axis, regulating the behavioural, endocrine, autonomic and immune responses to stress. Together with the recently discovered members of the CRF peptide family, urocortin 1, urocortin 2 and urocortin 3, it also has ne...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2007.07.003
更新日期:2008-01-31 00:00:00
abstract::A microscope-enlarger is described which can be used to produce 20 cm by 25 cm negatives of histological sections at magnifications up to 1,000 diameters, without loss of image quality or reduction of resolution. Standard flat-field microscope optics are used, and the apparatus is adjustable for Koehler illumination. ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(76)90058-7
更新日期:1976-01-01 00:00:00
abstract::Individual cardiac nerves from which stimulation elicited cardioinhibition (bradycardia and negative inotropism) were identified in 24 of 38 dogs. Subsequently, 3-25 microliters of 30% horseradish peroxidase (HRP) were injected into an identified cardiac nerve. After a 3-day survival period, the medulla oblongata was ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(82)90073-9
更新日期:1982-04-01 00:00:00
abstract::Neuronal nitric oxide synthase (nNOS) has been reported to be up-regulated in the hypothalamic supraoptic nucleus (SON) during dehydration which in turn could increase nitric oxide (NO) production and consequently affect arginine vasopressin (AVP) secretion. The anteroventral third ventricle (AV3V) region has strong a...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2011.07.020
更新日期:2011-10-10 00:00:00
abstract::Previous research has demonstrated that while primary visual cortex lesions in rats will disrupt performance of a learned brightness discrimination, the neural traces associated with this discrimination are spared. Moreover, the spared neural traces may, in certain instances, influence the postoperative reinstatement ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(78)90058-8
更新日期:1978-01-01 00:00:00
abstract::During normal ageing, photoreceptors of the human retina undergo various structural changes. We examined retinas from 33 donors (56 eyes; age span 13-94 years) by electron microscopy to see morphological changes in the cones with ageing. We show mitochondrial alterations and occurrence of electron-dense globules in th...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2006.09.007
更新日期:2006-12-11 00:00:00
abstract::Neurodevelopmental disorders such as autism and schizophrenia involve social interaction problems and poor mentalizing abilities, associated with abnormal regional cerebral activity. Similar problems may be present in aggressive personality disorders and psychopathy. This paper reviews brain imaging data from research...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2006.01.008
更新日期:2006-04-14 00:00:00