Differences in the ovulatory response to unilateral lesions in the preoptic or anterior hypothalamic area performed on each day of the estrous cycle of adult rats.

Abstract:

:The effects of a unilateral lesion made on the right or left side of the preoptic area (POA) or anterior hypothalamic area (AHA) made on each day of the estrous cycle, were analyzed. Ovulation rate decreased among the animals with a lesion performed on the day of estrous on the right side of POA (1/7 vs. 7/7, p < 0.05) and in animals with a lesion on diestrus-1 on each side AHA (4/9, 4/9 vs. 7/7, p < 0.05). Ovulation was restored by GnRH injection, while estradiol benzoate administration restored ovulation only in rats with a lesion on the right side of POA or AHA. We suggest that the participation of POA and AHA in the regulation of ovulation is asymmetric, lateralized, and changes during the estrous cycle. The estrogen-positive feedback needs the integrity of the left side of AHA on diestrus-1.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Morán JL,Cruz ME,Dominquez R

doi

10.1016/0361-9230(94)90230-5

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

663-8

issue

6

eissn

0361-9230

issn

1873-2747

pii

0361-9230(94)90230-5

journal_volume

33

pub_type

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