Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor.

abstract：:Rats were injected unilaterally into the rostral substantia nigra pars compacta with 8 micron of 6-OHDA. Those animals that conformed to be behavioral criteria for an effective nigrostriatal dopamine lesion by turning ipsilaterally to the injected side upon IP amphetamine, and contralaterally upon apomorphine injectio...

journal_title：Brain research bulletin

authors： Papadopoulos G,Huston JP,Nef B

更新日期：1981-02-01 00:00:00

abstract：:Since the groundbreaking work of Ramon y Cajal, the cerebellar Purkinje cell has always represented an ideal model for studying the organization, development and function of synaptic circuits. Purkinje cells receive distinct types of glutamatergic and GABAergic synapses, each characterized by exquisite sub-cellular an...

journal_title：Brain research bulletin

authors： Sassoè-Pognetto M,Patrizi A

更新日期：2017-03-01 00:00:00

abstract：:Inferior olive neurons, in brain slices maintained in vitro, display spontaneous, continuous oscillations of their membrane potential which are consonant with olivary rhythmic activity seen in vivo. This oscillatory behavior was studied with intracellular electrophysiological techniques. The 3-10 Hz rhythmicity of the...

journal_title：Brain research bulletin

authors： Benardo LS,Foster RE

更新日期：1986-12-01 00:00:00

abstract：:The alpha-2 adrenoreceptor agonist clonidine in low dose inhibits the release of noradrenaline and aggravates absence seizures. The present study examines properties of two types of spike-wave discharges (SWD) in a genetic model of absence epilepsy, the WAG/Rij rats. After reduction of noradrenergic neurotransmission ...

journal_title：Brain research bulletin

authors： Sitnikova E,van Luijtelaar G

更新日期：2005-01-30 00:00:00

abstract：:Sex differences are prominent influences on spatial performance. One of the most common tasks to assess sex differences in spatial navigation in rodents is the Morris water task (MWT). In this task rats swim in a pool of water to locate a hidden platform employing the topographical relationships among the distal visua...

journal_title：Brain research bulletin

authors： Faraji J,Metz GA,Sutherland RJ

更新日期：2010-01-15 00:00:00

abstract：:Hoe 065 is a compound structurally related to the angiotensin converting enzyme inhibitors and capable of increasing central cholinergic activity. The effects of this compound were studied on alcohol intake and on the reduction in alcohol intake produced by abutapril, an angiotensin converting enzyme inhibitor. Hoe 06...

journal_title：Brain research bulletin

authors： Grupp LA,Chow SY

更新日期：1991-04-01 00:00:00

abstract：:In a search for morphofunctional relationships in the head of the caudate nucleus (CN), we recorded extracellular unit activity in intact cats and in cats that had received bilateral injections of 6-OHDA into the substantia nigra (SN) 30 days previously. Only units firing spontaneously and continuously for 2 min were ...

journal_title：Brain research bulletin

authors： Gasteiger EL,Roig JA,Zarco-Coronado I,Estrada Y,Vargas E,Brust-Carmona H

更新日期：1984-01-01 00:00:00

abstract：:The present study in piglets was designed to examine cerebrovascular effects of tumor necrosis factor-alpha (TNF alpha) and potential mechanisms involved. Anesthetized new-born pigs with closed cranial windows implanted were used. Effects of nitric oxide synthase (NOS) inhibitors, NG-nitro-L-arginine (L-NNA) and amino...

journal_title：Brain research bulletin

authors： Shibata M,Parfenova H,Zuckerman SL,Leffler CW

更新日期：1996-01-01 00:00:00

abstract：:Although neural occlusion has been suggested to occur between the central and reflex mechanisms increasing arterial pressure, evidence consistent with this phenomenon is lacking. To assess the possibility of neural occlusion we recorded, in chloralose-anesthetized cats, the pressor responses to statically contracting ...

journal_title：Brain research bulletin

authors： Rybicki KJ,Stremel RW,Iwamoto GA,Mitchell JH,Kaufman MP

更新日期：1989-02-01 00:00:00

abstract：:Development and resolution of the lesion produced by occlusion of the middle cerebral artery (MCAO) was studied through quantitative planimetry and histologic/immunohistochemical techniques. MCAO, performed in spontaneously hypertensive rats (SHR), initially (1-3 days) produced large, consistent cerebral cortical infa...

journal_title：Brain research bulletin

authors： Clark RK,Lee EV,Fish CJ,White RF,Price WJ,Jonak ZL,Feuerstein GZ,Barone FC

更新日期：1993-01-01 00:00:00

abstract：:Cocaine is a major stimulant drug which can have rewarding and locomotor activating effects. It is used by non-addicts to enhance concentration and performance in a work or social setting. It was suggested that cocaine may amplify the impact of mood and sensory stimulation on behaviour. Here we tested whether cocaine ...

journal_title：Brain research bulletin

authors： Pum ME,Rubio AR,Carey RJ,Silva MA,Müller CP

更新日期：2011-02-28 00:00:00

abstract：:Trisomy of the whole or distal part of human chromosome 21 (HSA 21) (Ts21) results in Down Syndrome (DS), which is characterized in part by mental retardation and associated neurological abnormalities. Structural abnormalities observed frequently include reduced brain weight, decreased number and depth of sulci in the...

journal_title：Brain research bulletin

authors： Coyle JT,Oster-Granite ML,Gearhart JD

更新日期：1986-06-01 00:00:00

abstract：:This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found...

journal_title：Brain research bulletin

authors： Priori A,Ardolino G,Marceglia S,Mrakic-Sposta S,Locatelli M,Tamma F,Rossi L,Foffani G

更新日期：2006-12-11 00:00:00

abstract：:Following main olfactory bulb (MOB) stimulation at frequencies of 0.1-0.3 Hz, in addition to early field potentials, a frequency-sensitive, surface negative late N2 wave (latency range: 63-96 msec) followed occasionally by a late N3 transient, was evoked in the piriform cortex and endopiriform nucleus of the rat. The ...

journal_title：Brain research bulletin

authors： Ferreyra-Moyano H,Cinelli AR,Molina JC,Barragán E

更新日期：1988-04-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and brainstem MNs and the degeneration of the corticospinal tract. Degeneration of CSMNs and MNs leads inexorably to muscle wastage and weakness, ...

journal_title：Brain research bulletin

authors： Fogarty MJ

更新日期：2018-06-01 00:00:00

abstract：:In order to test the functional significance of noradrenergic neurotransmission for brain maturation, rat pups were injected daily with clonidine from 8-21 days of postnatal life. In adulthood, single cell responses to microiontophoretically applied neurotransmitters were studied in different layers of the hippocampus...

journal_title：Brain research bulletin

authors： Gorter JA,Mirmiran M,Bos NP,Van der Werf D

更新日期：1989-10-01 00:00:00

abstract：:The nucleus reticularis gigantocellularis of the rat medulla oblongata was perfused in situ, and effects of noxious stimuli on the release of immunoreactive Met-enkephalin were examined. Formalin-induced and thermal but not mechanical stimuli increased the "tonic" release of immunoreactive Met-enkephalin from this nuc...

journal_title：Brain research bulletin

authors： Kuraishi Y,Sugimoto M,Hamada T,Kayanoki Y,Takagi H

更新日期：1984-01-01 00:00:00

abstract：:The increase in life expectancy seen in many countries has been accompanied by an increase in the number of people living with dementia and a growing need for health care. The large number of affected individuals emphasizes the need to identify causes for the phenotypes associated with diseases such as Alzheimer's, Pa...

journal_title：Brain research bulletin

authors： Schengrund CL

更新日期：2010-04-29 00:00:00

abstract：:In rats, on the 25th day after the start of a thiamine-deficient (TD) diet, impairment of avoidance learning was significantly induced in proportion to the decrease somatostatin (SST) fluorescence intensity in the cortex, amygdala, thalamus, hypothalamus, and hippocampus, including the CA1, CA2, and dentate gyrus (DG)...

journal_title：Brain research bulletin

authors： Nakagawasai O,Tadano T,Niijima F,Tan-No K,Kisara K

更新日期：2000-01-01 00:00:00

abstract：:Direct intracellular measurements of excitability changes to injected current were made in 116 cortical neurons of awake cats following antidromic or orthodromic activation by repetitive, 1-6 Hz stimulation of the pes pedunculi. The predominant effect seen in antidromically activated cells was a transient decrease in ...

journal_title：Brain research bulletin

authors： Tzebelikos E,Woody CD

更新日期：1979-09-01 00:00:00

abstract：:Three sets of experiments have been conducted that suggest that adrenal glucocorticoids play a role in the long-term control of intake and in dietary preferences. First, obesity is dependent upon glucocorticoid-modulated metabolic pathways. Surgical or pharmacological manipulations in obese animals that eliminate or d...

journal_title：Brain research bulletin

authors： Castonguay TW

更新日期：1991-09-01 00:00:00

abstract：:Brain trauma can activate an attenuation of connexin gap junction that is implicated in neuronal injury, but the underlying cellular mechanisms remain incompletely understood. Here, we aimed to study whether autophagy, a stress-response process for recycling of intracellular proteins and organelles, is involved in the...

journal_title：Brain research bulletin

authors： Chen W,Guo Y,Yang W,Zheng P,Zeng J,Tong W

更新日期：2017-05-01 00:00:00

abstract：:In this study we investigated the ability of the dentate gyrus to independently generate cholinergically induced theta rhythm in vitro. Two different experiments were performed. In Experiment I, new laminar profiles of theta phase, amplitude, and current sources and sinks were constructed. In this experiment a gradual...

journal_title：Brain research bulletin

authors： Kowalczyk T,Gołebiewski H,Konopacki J

更新日期：2009-09-28 00:00:00

abstract：:Unit activities of thermosensitive (TS) and non-TS neurons in the medial preoptic area (MPO) of the monkey were investigated during a high fixed-ratio (FR 12-30) bar press behavior to seek cool air (CT) in a warm environment. The monkey performed the task when ambient temperature (Ta) was raised (35-43 degrees C) and ...

journal_title：Brain research bulletin

authors： Hori T,Kiyohara T,Oomura Y,Nishino H,Aou S,Fujita I

更新日期：1987-05-01 00:00:00

abstract：:Several lines of evidence have established that performance during the initial steps of acquisition on a shuttle-box avoidance task is an anxiety-mediated behavior (i.e., the differences between strains selectivity bred for emotionality; the effects of postnatal handling; the course of the corticosterone response and ...

journal_title：Brain research bulletin

authors： Fernández-Teruel A,Escorihuela RM,Núñez JF,Zapata A,Boix F,Salazar W,Tobeña A

更新日期：1991-01-01 00:00:00

abstract：:Windup, the frequency dependent build-up of spinal neuronal responses is an electrophysiological model of the development of the central sensitization in the chronic pain states. NR2B subunit containing NMDA-type glutamate receptors are implicated in the windup of dorsal horn neurons, while their role at the motoneuro...

journal_title：Brain research bulletin

authors： Kocsis P,Kovács G,Farkas S,Horváth C,Szombathelyi Z,Tarnawa I

更新日期：2004-08-30 00:00:00

abstract：:The biochemical balance between right- and left-ascending DA systems is an essential factor to regulate behavioral lateralization. However, there is no electrophysiological evidence for the regulation of interhemispheric DA systems. In the present paper we report electrophysiological evidence supporting the hypothesis...

journal_title：Brain research bulletin

authors： Castellano MA,Rodriguez Diaz M

更新日期：1991-08-01 00:00:00

abstract：:Fetal ventromedial hypothalamic (VMH) tissue was transplanted into or around the third ventricle of adult Fischer 344 rats to determine if transplanted VMH tissue could reverse the hyperphagia and obesity produced by bilateral VMH electrolytic lesions. Host VMH-lesioned rats received stereotaxic implants of 13 to 19 p...

journal_title：Brain research bulletin

authors： Ono K,Kawamura K,Shimizu N,Ito C,Plata-Salamán CR,Ogawa N,Oomura Y

更新日期：1990-01-01 00:00:00

abstract：:It is known that spinal nociceptive sensory transmission receives descending inhibitory and facilitatory modulation from supraspinal structures. Glutamate is the major fast excitatory transmitter between primary afferent fibers and spinal dorsal horn neurons. In whole-cell patch clamp recordings from dorsal horn neuro...

journal_title：Brain research bulletin

authors： Li P,Zhuo M

更新日期：2001-04-01 00:00:00

abstract：:Tolperisone is a voltage gated sodium channel blocker, centrally acting muscle relaxant drug, with a very advantageous side effect profile. Like other sodium channel blockers, it has weak affinity to the resting state and high affinity to the open/inactivated state of the channel. In this paper, its effect on BOLD res...

journal_title：Brain research bulletin

authors： Kocsis P,Gajári D,Deli L,Gőcze KZ,Pozsgay Z,Tihanyi K

更新日期：2013-10-01 00:00:00