Hippocampal neuronal responsiveness to different neurotransmitters in the adult rat after neonatal interference with noradrenaline transmission.

Abstract:

:In order to test the functional significance of noradrenergic neurotransmission for brain maturation, rat pups were injected daily with clonidine from 8-21 days of postnatal life. In adulthood, single cell responses to microiontophoretically applied neurotransmitters were studied in different layers of the hippocampus. No significant differences were found in neuronal responsiveness to glutamate, GABA, or acetylcholine in the hippocampus of clonidine-treated rats as compared with age-matched controls. However, there was a significantly stronger depression of glutamate-evoked activity of CA1 pyramidal neurons by noradrenaline in the clonidine-treated rats.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Gorter JA,Mirmiran M,Bos NP,Van der Werf D

doi

10.1016/0361-9230(89)90212-8

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

293-7

issue

4-5

eissn

0361-9230

issn

1873-2747

pii

0361-9230(89)90212-8

journal_volume

23

pub_type

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