Oscillatory behavior in inferior olive neurons: mechanism, modulation, cell aggregates.


:Inferior olive neurons, in brain slices maintained in vitro, display spontaneous, continuous oscillations of their membrane potential which are consonant with olivary rhythmic activity seen in vivo. This oscillatory behavior was studied with intracellular electrophysiological techniques. The 3-10 Hz rhythmicity of these cells from guinea pigs is tetrodotoxin resistant and dependent on a somatic calcium conductance. The oscillatory behavior can exhibit intrinsic frequency modulation and can be altered by synaptic processes. Synaptic alteration of the oscillatory behavior by afferent sources and extensive electrotonic coupling between cells in local aggregates (shown by Lucifer yellow dye-coupling) provide the substrate for a potent central pattern generator with a well established efferent pathway for control of motor functions.


Brain Res Bull


Brain research bulletin


Benardo LS,Foster RE




Has Abstract


1986-12-01 00:00:00














  • Comparison of fractal and power spectral EEG features: effects of topography and sleep stages.

    abstract::Fractal nature of the human sleep EEG was revealed recently. In the literature there are some attempts to relate fractal features to spectral properties. However, a comprehensive assessment of the relationship between fractal and power spectral measures is still missing. Therefore, in the present study we investigated...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Weiss B,Clemens Z,Bódizs R,Halász P

    更新日期:2011-04-05 00:00:00

  • Immunohistochemical and chromatographic identification of peptides derived from proneuropeptide Y in the human frontal cortex.

    abstract::Proneuropeptide Y (proNPY) is posttranslationally processed to NPY(1-36)amide and the C-terminal flanking peptide of NPY (CPON). Antisera directed against the N-terminal part of NPY, CPON, or CysNPY(32-36)amide were used to identify peptide fragments processed from proNPY in biopsies of human frontal cortical specimen...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Mikkelsen JD,Larsen PJ,Kruse-Larsen C,O'Hare MM,Schwartz TW

    更新日期:1993-01-01 00:00:00

  • NMDA receptor activity in learning spatial procedural strategies I. The influence of hippocampal lesions.

    abstract::To acquire knowledge about the environment two types of learning are necessary: declarative localizatory learning about where environmental cues and the subject are, and procedural learning about how to explore and move around the environment. Experimental data indicate that hippocampal regions are involved in spatial...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Leggio MG,Federico F,Neri P,Graziano A,Mandolesi L,Petrosini L

    更新日期:2006-10-16 00:00:00

  • Amyloid precursor protein processing and bioenergetics.

    abstract::The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Wilkins HM,Swerdlow RH

    更新日期:2017-07-01 00:00:00

  • A stereotaxic atlas of the grey lesser mouse lemur brain (Microcebus murinus).

    abstract::In response to the growing interest in the prosimian Microcebus murinus for studies on cerebral aging, the stereotaxic atlas of its brain was carried out in view of further anatomical, biochemical, electrophysiological, and behavioral investigations as well as for therapeutic experiments. This primate, which could be ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Bons N,Silhol S,Barbié V,Mestre-Francés N,Albe-Fessard D

    更新日期:1998-05-01 00:00:00

  • Effects of hyperprolactinaemia on core temperature of the rat.

    abstract::The effects of endogenous hyperprolactinaemia (HPRL), as induced by pituitary homografts under the kidney capsule, on core temperature (Tc) was investigated in rats before and after the application of restraint stress. HPRL was accompanied by a significant decrease in Tc of freely moving rats, as observed for four day...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Drago F,Amir S

    更新日期:1984-04-01 00:00:00

  • Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats.

    abstract::Pax6 is an important transcription factor expressed in several discrete domains of the developing central nervous system. It has been reported that Pax6 is involved in the specification of subtypes of hindbrain motor neurons. Pax6 homozygous mutant (rSey2/rSey2) rats die soon after birth, probably due to impaired resp...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Ikeda K,Onimaru H,Inada H,Tien Lin S,Arata S,Osumi N

    更新日期:2019-10-01 00:00:00

  • Nimodipine represses AMPK phosphorylation and excessive autophagy after chronic cerebral hypoperfusion in rats.

    abstract::Chronic cerebral hypofusion (CCH) after bilateral carotid artery occlusion (2VO) causes cognitive damage and neuronal degeneration in the cortex and hippocampal CA1 area, and influences the oxygen and glucose supply in the brain which often results in metabolic alterations and oxidative stress. AMP-activated protein k...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Chen Y,Guo Z,Peng X,Xie W,Chen L,Tan Z

    更新日期:2018-06-01 00:00:00

  • Centrally administered CYP2D inhibitors increase oral tramadol analgesia in rats.

    abstract::Cytochrome P450 2D (CYP2D) mediates the activation and inactivation of several classes of psychoactive drugs, including opioids, which can alter drug response. Tramadol is a synthetic opioid with analgesic activity of its own as well as being metabolically activated by CYP2D to O-desmethyltramadol (ODMST) an opioid re...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: McMillan DM,El-Sherbeni AA,Richards J,Tyndale RF

    更新日期:2020-11-01 00:00:00

  • Minimal surface: a useful paradigm to describe the deeper part of the corpus callosum?

    abstract::The aim of this magnetic resonance imaging study was to find a geometrical characterization of the deeper part of the corpus callosum. Its shape was studied in 12 middle-aged persons free of white matter pathology. Profiles of curvatures were measured showing that this surface was close to a minimal one, especially at...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Stievenart JL,Iba-Zizen MT,Tourbah A,Lopez A,Thibierge M,Abanou A,Cabanis EA

    更新日期:1997-01-01 00:00:00

  • CB1-cannabinoid-, TRPV1-vanilloid- and NMDA-glutamatergic-receptor-signalling systems interact in the prelimbic cerebral cortex to control neuropathic pain symptoms.

    abstract::Neuropathic pain (NP) is a challenge due to our limited understanding of the mechanisms that initiate and maintain chronic pain. The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is an important area of the emotional and cognitive components of pain and pharmacological systems can interact into the n...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Medeiros P,Oliveira-Silva M,Negrini-Ferrari SE,Medeiros AC,Elias-Filho DH,Coimbra NC,de Freitas RL

    更新日期:2020-12-01 00:00:00

  • Hypothalamic c-fos-like immunoreactivity in high-fat diet-induced obese and resistant mice.

    abstract::Some C57Bl/6 mice become obese, whereas others remain lean when raised on a high-fat diet. The mechanisms underlying this interindividual susceptibility to diet-induced obesity remain unknown. Because hypothalamus plays a major role in the regulation of body weight, this study was conducted to identify the differences...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Xin X,Storlien LH,Huang XF

    更新日期:2000-07-01 00:00:00

  • Neuroprotective role of alendronate against APP processing and neuroinflammation in mice fed a high fat diet.

    abstract::Obesity and consumption of diet rich in fat are known to contribute to the development of Alzheimer's disease (AD) which is a complex and multifactorial neurodegenerative disease and a leading cause of mortality with unmet medical needs. Hypercholesterolemia was discovered to increase neuropathological changes along w...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Zameer S,Alam M,Hussain S,Vohora D,Ali J,Najmi AK,Akhtar M

    更新日期:2020-08-01 00:00:00

  • Altered reactivity of the rat adrenal medulla.

    abstract::Previous studies have suggested that experimental alterations in adrenomedullary reactivity, i.e., changes in catecholamine release in response to a standard dose of acetylcholine, may be partially accounted for by changes occurring at the level of the adrenal medulla itself, independent of both the central nervous sy...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Carbonaro DA,Mitchell JP,Hall FL,Vulliet PR

    更新日期:1988-09-01 00:00:00

  • Colocalization of neuropeptides with calcium-binding proteins in the claustral interneurons during postnatal development of the rat.

    abstract::The claustrum is a relatively large telencephalic structure, situated close to the border of the neo- and allocortical regions. Its neuronal population consists of glutamatergic, projecting neurons and GABA-ergic interneurons, characterized by occurrence of numerous additional biochemical markers. The postnatal develo...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Kowiański P,Dziewiatkowski J,Moryś JM,Majak K,Wójcik S,Edelstein LR,Lietzau G,Moryś J

    更新日期:2009-09-28 00:00:00

  • Methylphenidate modulates dorsal raphe neuronal activity: Behavioral and neuronal recordings from adolescent rats.

    abstract::Methylphenidate (MPD) is a widely prescribed psychostimulants used for the treatment of attention deficit hyperactive disorder (ADHD). Unlike the psychostimulants cocaine and amphetamine, MPD does not exhibit direct actions on the serotonin transporter, however there is evidence suggesting that the therapeutic effects...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Kharas N,Whitt H,Reyes-Vasquez C,Dafny N

    更新日期:2017-01-01 00:00:00

  • NR2B receptors are involved in the mediation of spinal segmental reflex potentials but not in the cumulative motoneuronal depolarization in vitro.

    abstract::Windup, the frequency dependent build-up of spinal neuronal responses is an electrophysiological model of the development of the central sensitization in the chronic pain states. NR2B subunit containing NMDA-type glutamate receptors are implicated in the windup of dorsal horn neurons, while their role at the motoneuro...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Kocsis P,Kovács G,Farkas S,Horváth C,Szombathelyi Z,Tarnawa I

    更新日期:2004-08-30 00:00:00

  • Plasma gonadotropin, prolactin levels and hypothalamic tyrosine hydroxylase activity following intraventricular bombesin and secretin in ovariectomized conscious rats.

    abstract::Plasma gonadotropins, prolactin and hypothalamic tyrosine hydroxylase (TH) activity were evaluated at 15 and 30 min after third ventricular injection of bombesin at doses of 100 or 1000 ng and secretin at doses of 1000 and 5000 ng in ovariectomized (OVX) unanesthetized rats. Bombesin had no effect on plasma gonadotrop...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Babu GN,Vijayan E

    更新日期:1983-07-01 00:00:00

  • Maternal infection during late pregnancy increases anxiety- and depression-like behaviors with increasing age in male offspring.

    abstract::Scientific reports suggest that the exposure to long-term stressors throughout or during late gestation increase anxiety- and depression-like behaviors of offspring in their later life. Moreover, several studies concluded that increasing age correlates with increased anxiety behaviors in humans and rodents. In the pre...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Enayati M,Solati J,Hosseini MH,Shahi HR,Saki G,Salari AA

    更新日期:2012-02-10 00:00:00

  • Dynorphin-mediated antinociceptive effects of L-arginine and SIN-1 (an NO donor) in mice.

    abstract::The antinociceptive response of mice to the amino acid L-arginine (L-ARG) has been attributed to either an opioid mechanism or a non-opioid but nitric oxide (NO)-dependent mechanism. Earlier it was reported that the mechanism of nitrous oxide-induced antinociception involved opioid components and was also dependent on...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Chung E,Burke B,Bieber AJ,Doss JC,Ohgami Y,Quock RM

    更新日期:2006-07-31 00:00:00

  • Dopamine receptor antagonist blocks the release of glycine, GABA, and taurine produced by amphetamine.

    abstract::The effects of systemic injections of amphetamine sulfate on the extracellular levels of glycine, GABA, and taurine in the neostriatum of awake rats were studied using a push-pull perfusion system. Amphetamine produced a dose-related increase in glycine levels. Amphetamine also produced an enhancement on GABA and taur...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Porras A,Mora F

    更新日期:1993-01-01 00:00:00

  • Evidence for reciprocal connections between the dorsochiasmatic area and the hypothalamo neurohypophyseal system and some related extrahypothalamic structures.

    abstract::In the preceding article, a dorsochiasmatic area (DCh) was described that projects to both paraventricular (PVN) and supraoptic (SON) nuclei. The main afferents of the DCh, revealed by local injections of retrograde tracers, are the hypothalamic PVN and SON, lateral septal nuclei (LSV and SHy), bed nuclei of the stria...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Thellier D,Moos F,Richard P,Stoeckel ME

    更新日期:1994-01-01 00:00:00

  • Inflammatory system gene polymorphism and the risk of stroke: a case-control study in an Indian population.

    abstract::Sequence variations in genes involved in inflammation system are known to contribute to the risk of cardiovascular diseases (CVD) including stroke. In this study, we performed a genetic association study on the single nucleotide polymorphisms (SNPs) present in the genes CD14 (-159 C/T), TNFalpha (-308 G/A), IL-1alpha ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Banerjee I,Gupta V,Ahmed T,Faizaan M,Agarwal P,Ganesh S

    更新日期:2008-01-31 00:00:00

  • GFAP expression withdraws--a trend of glial evolution?

    abstract::This study is a summary of investigations in the last decade with several collaborators on representatives of different vertebrate stocks. The results suggest that in the main vertebrate stocks (Agnathi, Chondrichthyes, Actinopterygii, Sarcopterygii-Amniotes), which had their parallel brain evolutions from the laminar...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Kálmán M

    更新日期:2002-02-01 00:00:00

  • Long-term changes in phosphoinositide hydrolysis following colchicine lesions of the nucleus basalis magnocellularis.

    abstract::The effect of bilateral colchicine lesions of the nucleus basalis magnocellularis (NBM) on agonist-stimulated phosphoinositide (PI) hydrolysis was examined in cortical slices 1, 3, or 14 months after surgery. Colchicine lesions resulted in a loss of acetylcholinesterase staining in the cortex which recovered to contro...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Mundy WR,Tandon P,Barone S Jr,Tilson HA

    更新日期:1991-04-01 00:00:00

  • Effects of the metabotropic glutamate receptor agonist, ACPD, on the extracellular concentrations of GABA and acetylcholine in the prefrontal cortex of the rat during the normal process of aging.

    abstract::The aim of the present study was to investigate the effects of activation of metabotropic glutamate receptors (mGluR) on the extracellular concentrations of GABA and acetylcholine in the prefrontal cortex of freely moving rats of different groups of age. Perfusion, through the microdialysis probe, of the agonist of mG...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Segovia G,Mora F

    更新日期:2005-02-15 00:00:00

  • Exercise suppresses COX-2 pro-inflammatory pathway in vestibular migraine.

    abstract::Migraine and dizziness are relatively common disorders. Patients with dizziness have a higher incidence of migraines than the general population. The discomfort experienced by these patients is often poorly controlled by medication. However, the pathophysiology of vestibular migraine (VM) remains unclear. We hypothesi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Lee YY,Yang YP,Huang PI,Li WC,Huang MC,Kao CL,Chen YJ,Chen MT

    更新日期:2015-07-01 00:00:00

  • Central vestibular system: vestibular nuclei and posterior cerebellum.

    abstract::The vestibular nuclei and posterior cerebellum are the destination of vestibular primary afferents and the subject of this review. The vestibular nuclei include four major nuclei (medial, descending, superior and lateral). In addition, smaller vestibular nuclei include: Y-group, parasolitary nucleus, and nucleus inter...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Barmack NH

    更新日期:2003-06-15 00:00:00

  • Human auditory evoked potentials: reliability of intensity functions.

    abstract::This investigation assessed the relative reliability of the human auditory evoked potential (AEP) amplitude-intensity and latency-intensity functions. Averaged AEP waveforms to 10 levels of stimulus magnitude were obtained from bipolar recordings. Variability and slope of group functions were constant, as indicated by...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Browman CP,Sullivan HT

    更新日期:1980-03-01 00:00:00

  • Modulation of hypothalamic mu-opioid receptor density by estrogen: a quantitative autoradiographic study of the female C57BL/6J mouse.

    abstract::The labelling of hypothalamic binding sites by [125I]-FK, a specific mu-opioid receptor ligand, was studied in female C57BL/6J mice to test whether removal of ovarian steroids affected the density of distribution of receptor binding. Labelling densities in the forebrain of normally cycling (intact) females (N = 12), w...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Joshi D,Billiar RB,Miller MM

    更新日期:1993-01-01 00:00:00