Abstract:
:Polymerase chain reaction assays are a powerful tool for detecting the presence of infectious genomes in the cerebrospinal fluid. Positive results always mean a current or pending infection of the central nervous system. Subacute (>7 days) or chronic infections induce an intrathecal humoral immune response and the appearance of oligoclonal IgG antibodies directed against the causal infectious agent. This local synthesis may be observed even in cases of severe systemic immunodeficiency. The use of polymerase chain reactions in combination with the detection of a specific intrathecal immune response should represent the most reliable strategy for the diagnosis of viral and chronic infections of the central nervous system. The authors describe their experience, using this approach, in herpetic encephalitis, acute and recurrent herpetic meningitis, varicella zoster-induced neurological diseases, cytomegalovirus encephalitis, progressive multifocal leukoencephalitis and tuberculous meningitis.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Sindic CJ,Van Antwerpen MP,Goffette Sdoi
10.1016/s0361-9230(03)00093-5keywords:
subject
Has Abstractpub_date
2003-08-15 00:00:00pages
299-308issue
3eissn
0361-9230issn
1873-2747pii
S0361923003000935journal_volume
61pub_type
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