Abstract:
:The effects of intracerebroventricular (ICV) injection of neuropeptide Y (NPY) on parameters of dopamine (DA), glutamate (Glu) and gamma-aminobutyric acid (GABA) activities were investigated in the rat striatum. NPY (1.17-4.70 nmol) induced a dose-dependent increase in the striatal endogenous DA release monitored in freely moving animals by means of a voltammetric method. Maximal increase was observed about one hour after the peptide injection. This result is consistent with the hypothesis that NPY may influence striatal DA turnover in a facilitatory manner by activating DA release. DA, DOPAC, Glu and GABA endogenous contents as well as 3H-Glu and 3H-GABA synaptosomal high affinity uptakes were examined one hour after NPY ICV administration at the same dose range in chloral hydrate-anesthetized animals. Depending on the NPY dose injected, opposite changes in Glu uptake were observed, suggesting that NPY has a bimodal influence on glutamatergic transmission. The Glu uptake rate increased markedly at 1.17 nmol NPY and decreased at 4.70 nmol, which may reflect an activation and an inhibition of the striatal Glu transmission, respectively. In parallel, the GABA uptake was found to decrease slightly at the higher doses of NPY tested, whereas no significant alteration of the striatal concentrations of either DA, DOPAC, Glu or GABA was observed. These results indicate that NPY may be involved in regulating the activity of nigral dopaminergic and cortical glutamatergic afferent pathways and that of intrinsic GABA neurons in the rat striatum.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Kerkerian-Le Goff L,Forni C,Samuel D,Bloc A,Dusticier N,Nieoullon Adoi
10.1016/0361-9230(92)90178-zkeywords:
subject
Has Abstractpub_date
1992-02-01 00:00:00pages
187-93issue
2eissn
0361-9230issn
1873-2747pii
0361-9230(92)90178-Zjournal_volume
28pub_type
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更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0361-9230(90)90176-z
更新日期:1990-12-01 00:00:00
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pub_type: 杂志文章
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