Intracerebroventricular administration of neuropeptide Y affects parameters of dopamine, glutamate and GABA activities in the rat striatum.

Abstract:

:The effects of intracerebroventricular (ICV) injection of neuropeptide Y (NPY) on parameters of dopamine (DA), glutamate (Glu) and gamma-aminobutyric acid (GABA) activities were investigated in the rat striatum. NPY (1.17-4.70 nmol) induced a dose-dependent increase in the striatal endogenous DA release monitored in freely moving animals by means of a voltammetric method. Maximal increase was observed about one hour after the peptide injection. This result is consistent with the hypothesis that NPY may influence striatal DA turnover in a facilitatory manner by activating DA release. DA, DOPAC, Glu and GABA endogenous contents as well as 3H-Glu and 3H-GABA synaptosomal high affinity uptakes were examined one hour after NPY ICV administration at the same dose range in chloral hydrate-anesthetized animals. Depending on the NPY dose injected, opposite changes in Glu uptake were observed, suggesting that NPY has a bimodal influence on glutamatergic transmission. The Glu uptake rate increased markedly at 1.17 nmol NPY and decreased at 4.70 nmol, which may reflect an activation and an inhibition of the striatal Glu transmission, respectively. In parallel, the GABA uptake was found to decrease slightly at the higher doses of NPY tested, whereas no significant alteration of the striatal concentrations of either DA, DOPAC, Glu or GABA was observed. These results indicate that NPY may be involved in regulating the activity of nigral dopaminergic and cortical glutamatergic afferent pathways and that of intrinsic GABA neurons in the rat striatum.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Kerkerian-Le Goff L,Forni C,Samuel D,Bloc A,Dusticier N,Nieoullon A

doi

10.1016/0361-9230(92)90178-z

keywords:

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

187-93

issue

2

eissn

0361-9230

issn

1873-2747

pii

0361-9230(92)90178-Z

journal_volume

28

pub_type

杂志文章
  • Inhibitory effect of regucalcin on Ca(2+)-dependent protein kinase activity in rat brain cytosol: involvement of endogenous regucalcin.

    abstract::The effect of regucalcin, a Ca(2+)-binding protein, on Ca(2+)-dependent protein kinase activity in the brain cytosol of rats with different ages (5 and 50 weeks old) was investigated. The addition of calmodulin (10 microg/ml) or dioctanoylglycerol (5 microg/ml) in the enzyme reaction mixture caused a significant incre...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(99)00184-7

    authors: Hamano T,Hanahisa Y,Yamaguchi M

    更新日期:1999-10-01 00:00:00

  • Development of the dopamine-immunoreactive system in the central nervous system of the sea lamprey.

    abstract::The development of dopamine-immunoreactive (DAir) populations in the central nervous system of the sea lamprey, a modern representative of the earliest vertebrates, was studied to achieve further understanding of dopaminergic systems in vertebrates. The first DAir cell groups appeared in the spinal cord, the posterior...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2005.05.004

    authors: Abalo XM,Villar-Cheda B,Anadón R,Rodicio MC

    更新日期:2005-09-15 00:00:00

  • Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation.

    abstract::The effect of pretreatment of geranylgeranylacetone (GGA), an inducer of heat shock protein (HSP) 70, on responses in sleep and core body temperature (Tcore) against sleep deprivation (SD) was examined in rats. After 3 days of GGA or vehicle injection, a 6-h period of SD was performed. During the recovery period, both...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2006.02.004

    authors: Wada T,Sei H,Kusumoto K,Kitaoka K,Chikahisa S,Rokutan K,Morita Y

    更新日期:2006-04-28 00:00:00

  • Recovery of function in spinalized, neonatal rats.

    abstract::Neonatal rats, when spinalized on the fourteenth postnatal day, showed minimal recovery of function in their hindlimbs. Bridging the cut spinal cord with E16 fetal spinal cord tissue did not improve functional recovery. Bridging, plus treatment with GM1 ganglioside, caused a significant (p less than 0.05) improvement ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(91)90272-l

    authors: Commissiong JW,Sauve Y,Csonka K,Karoum F,Toffano G

    更新日期:1991-07-01 00:00:00

  • The neuroprotective efficacy of alpha-crystallin against acute inflammation in mice.

    abstract::Acute inflammation activates macrophages or monocytes and subsequently releases several inflammatory cytokines and reactive oxygen and nitrogen species. These proinflammatory cytokines activate astrocytes and trigger neurodegenerative diseases. In this work, we chose to address the mechanistic aspects of alpha-crystal...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2005.07.002

    authors: Masilamoni JG,Vignesh S,Kirubagaran R,Jesudason EP,Jayakumar R

    更新日期:2005-10-15 00:00:00

  • Neuroprotective effects of penehyclidine hydrochloride against cerebral ischemia/reperfusion injury in mice.

    abstract::Various reports have suggested that penehyclidine hydrochloride (PHC), a new cholinergic antagonist, exhibits a variety of biological actions such as anti-tumor and cardioprotective effects. This study aimed to investigate the effects of PHC on cerebral ischemia/reperfusion (I/R) injury and evaluate whether the c-Jun ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2016.01.008

    authors: Shu Y,Yang Y,Zhang P

    更新日期:2016-03-01 00:00:00

  • Modulation of central endocannabinoid system results in gastric mucosal protection in the rat.

    abstract::Previous findings showed that inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), degrading enzymes of anandamide (2-AEA) and 2-arachidonoylglycerol (2-AG), reduced the nonsteroidal anti-inflammatory drug-induced gastric lesions. The present study aimed to investigate: i./whether centra...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2018.02.012

    authors: Tóth VE,Fehér Á,Németh J,Gyertyán I,Zádori ZS,Gyires K

    更新日期:2018-05-01 00:00:00

  • Role of iNOS-NO-cGMP signaling in modulation of inflammatory and myelination processes.

    abstract::Nitric oxide (NO) is the main activator of the soluble guanylate cyclase (sGC)-guanosine 3'5' cyclic monophosphate (cGMP) pathway. The level of cGMP is regulated by phosphodiesterases (PDEs), which break down cGMP. It has been reported that levels of NO in the central nervous system (CNS) can greatly increase during d...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2014.04.002

    authors: Rapôso C,Luna RL,Nunes AK,Thomé R,Peixoto CA

    更新日期:2014-05-01 00:00:00

  • Long lasting changes in the spontaneous activity of hippocampal neurons following stimulation of the entorhinal cortex.

    abstract::The spontaneous activity of hippocampal and denate units was investigated in acute and chronic experiments on adult rats. Spontaneous unitary discharges from both regions were measured before and after brief tetanic stimulation of the entorhinal cortex. An increase in the frequency of spontaneous unit activity was obt...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(76)90043-5

    authors: Deadwyler SA,Gribkoff V,Cotman C,Lynch G

    更新日期:1976-01-01 00:00:00

  • A microassay for measuring synaptosomal 3H-dopamine and 3H-metabolite release.

    abstract::A modified synaptosomal superfusion apparatus is described which uses less than 10 micrograms of tissue per replicate sample and facilitates the routine separation of 3H-DA, 3H-DOPAC, and 3H-HVA. A flow rate of 1.5 ml/min allows superfusion without the use of reuptake or monoamine oxidase inhibitors. Superfusate sampl...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(90)90232-o

    authors: Petrie EC,Lombrozo L,Csernansky JG

    更新日期:1990-09-01 00:00:00

  • Cervical stimulation activates A1 and locus coeruleus neurons that project to the paraventricular nucleus of the hypothalamus.

    abstract::In female rats, stimulation of the uterine cervix during mating induces two daily surges of prolactin. Inhibition of hypothalamic dopamine release and stimulation of oxytocin neurons in the paraventricular nucleus (PVN) are required for prolactin secretion. We aim to better understand how stimulation of the uterine ce...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2012.06.004

    authors: Poletini MO,McKee DT,Szawka RE,Bertram R,Helena CV,Freeman ME

    更新日期:2012-09-01 00:00:00

  • Temporal and regional expression of Fos-related proteins in response to ischemic injury.

    abstract::The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for contr...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2003.12.005

    authors: Butler TL,Pennypacker KR

    更新日期:2004-03-01 00:00:00

  • Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats.

    abstract::The non-adenosine nucleoside guanosine (Guo) was demonstrated to decrease quinolinic acid(QA)-induced seizures, spontaneously emerged absence epileptic seizures and lipopolysaccharide(LPS)-evoked induction of absence epileptic seizures suggesting its antiepileptic potential. It was also described previously that intra...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2016.05.001

    authors: Lakatos RK,Dobolyi Á,Todorov MI,Kékesi KA,Juhász G,Aleksza M,Kovács Z

    更新日期:2016-06-01 00:00:00

  • Peptide displacement of [3H]5-hydroxytryptamine binding to bovine cortical membranes.

    abstract::Chemical studies have demonstrated that peptides such as the encephalitogenic (EAE) peptide of myelin basic protein (MBP) and luteinizing hormone-releasing hormone (LHRH) can bind serotonin (5-hydroxytryptamine, 5-HT) in vitro. The present research was undertaken to determine whether such binding interferes with 5-HT ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(90)90176-z

    authors: Takeuchi Y,Root-Bernstein RS,Shih JC

    更新日期:1990-12-01 00:00:00

  • Lesions dorsal to the suprachiasmatic nuclei abolish split activity rhythms of hamsters.

    abstract::Constant light exposure (LL) can result in "splitting" of circadian rhythms into two components coupled about 12 hr apart. Splitting has been interpreted as evidence for the presence of two main oscillators or groups of oscillators underlying circadian rhythms. Abolition of splitting after unilateral suprachiasmatic n...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(90)90164-u

    authors: Harrington ME,Eskes GA,Dickson P,Rusak B

    更新日期:1990-04-01 00:00:00

  • Excitation of hypothalamic paraventricular neurons by stimulation of the raphe nuclei.

    abstract::Extracellular recordings were made from 467 anti-dromically identified neurosecretory neurons and 148 non-neurosecretory neurons in the paraventricular nucleus of the hypothalamus of hemispherectomized cats under pentobarbital anesthesia. Stimulation of the dorsal, median, and pontine raphe nuclei excited 31%, 26%, an...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(92)90105-7

    authors: Kawano S,Osaka T,Kannan H,Yamashita H

    更新日期:1992-04-01 00:00:00

  • When is a view unusual? A single case study of orientation-dependent visual agnosia.

    abstract::Several hypotheses have been proposed to explain why some neurological patients fail to recognise objects from unusual views: that it results from difficulty identifying an object's principal axis when it is foreshortened, identifying an object when landmark features are occluded, or an inability to rotate mental imag...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(96)00148-7

    authors: Turnbull OH,McCarthy RA

    更新日期:1996-01-01 00:00:00

  • Effect of progesterone on monoamine turnover in the brain of the estrogen-primed rat.

    abstract::The effect of progesterone (P) on monoamine levels and turnover was evaluated in 8 brain nuclei in estrogen-primed rats. Animals were subcutaneously (SC) injected with P or vehicle 21 hours after SC treatment with 5 micrograms of estradiol benzoate (EB). EB-primed animals treated with P showed high levels of lordosis ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(87)90085-2

    authors: Renner KJ,Krey LC,Luine VN

    更新日期:1987-08-01 00:00:00

  • The response of central glia to peripheral nerve injury.

    abstract::Microglial and astroglial cells undergo prompt responses to peripheral motor and sensory axon injury. These responses include proliferation of microglial cells as well as hypertrophy and increased levels of glial fibrillary acidic protein around the axotomized motoneurons and in the central projection territories of p...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/0361-9230(93)90284-i

    authors: Svensson M,Eriksson P,Persson JK,Molander C,Arvidsson J,Aldskogius H

    更新日期:1993-01-01 00:00:00

  • The latent period of the Limulus lateral eye receptor potential: action of chlorobutanol.

    abstract::Excised lateral eye retinular cells of Limulus polyphemus exposed to chlorobutanol were examined using microelectrode techniques. The effects observed were: (1) a marked shortening of the receptor potential latent period; (2) a decrease in the effective input resistance of retinular cells to hyperpolariziog currents; ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(77)90038-7

    authors: Wulff VJ,Jahy JL

    更新日期:1977-05-01 00:00:00

  • The medullary dorsal reticular nucleus facilitates acute nociception in the rat.

    abstract::The influence on pain processing caused by destruction or stimulation of the dorsal reticular nucleus (DRt) was studied using the tail-flick and the increasing temperature hot-plate tests. Lesions of the DRt were obtained by injecting quinolinic acid (180 nmol/microliters) unilaterally or bilaterally, and nociceptive ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(95)02027-6

    authors: Almeida A,Tjølsen A,Lima D,Coimbra A,Hole K

    更新日期:1996-01-01 00:00:00

  • Development of the serotonergic system in the rat embryo: an immunocytochemical study.

    abstract::The development of central serotonergic neurons has been examined immunocytochemically utilizing an antiserum to serotonin (5-HT). Cells of the B4-B9 complex are first detected early on embryonic day 13 (E13; 7 mm crown rump length, CRL) and increase rapidly in number through E15 when they appear as bilateral columns ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(83)90144-2

    authors: Wallace JA,Lauder JM

    更新日期:1983-04-01 00:00:00

  • Control of the body vertical by vestibular and proprioceptive inputs.

    abstract::The study examines the influence of vestibular and leg proprioceptive cues on the maintenance of the body vertical in human stance. Vestibular body orientation cues were changed by applying bipolar currents to both mastoid bones (cosine-bell wave form of 3.3 s duration, 1 mA current intensity). Proprioceptive input wa...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(96)00138-4

    authors: Hlavacka F,Mergner T,Krizkova M

    更新日期:1996-01-01 00:00:00

  • Medicine and science in the life of Luigi Galvani (1737-1798).

    abstract::Together with its companion paper, dealing with the contribution of Luigi Galvani to the history of electrophysiology, this article provides a biographical sketch of the scientist of Bologna in the occasion of the bicentenary of his death. Studies on Galvani have focused mainly on his "discovery" of animal electricity...

    journal_title:Brain research bulletin

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/s0361-9230(98)00023-9

    authors: Bresadola M

    更新日期:1998-07-15 00:00:00

  • Lactation diminishes lesion-induced permeability of tracers into the brain.

    abstract::Diminished sensitivity to kainic acid (KA) lesioning action is present in the hippocampus of the lactating dam. Given that KA can alter blood-brain barrier (BBB) permeability, we investigated whether lactation would protect BBB permeability after treatment with this neurotoxin. Adult virgin or lactating (13-15 days pp...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2018.11.020

    authors: Solís CD,Morales T

    更新日期:2019-01-01 00:00:00

  • Research progress and treatment strategies for anesthetic neurotoxicity.

    abstract::Every year, a large number of infants and young children worldwide are administered general anesthesia. Whether general anesthesia adversely affects the intellectual development and cognitive function of children at a later date remains controversial. Many animal experiments have shown that general anesthetics can cau...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainresbull.2020.08.003

    authors: Yang F,Zhao H,Zhang K,Wu X,Liu H

    更新日期:2020-11-01 00:00:00

  • Contribution of spinal N-methyl-D-aspartic acid receptors to control of sympathetic outflow by the paraventricular nucleus.

    abstract::Spinal NMDA receptors contribute to control of the cardiovascular system by the ventrolateral medulla. However, little is known about the contribution of these receptors to suprabulbar regulation of hemodynamics and sympathetic outflow. Hence, the involvement of spinal NMDA receptors in regulation of the cardiovascula...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(93)90169-c

    authors: Porter JP

    更新日期:1993-01-01 00:00:00

  • Mu and delta opiate receptors in rat brain are affected by GTP but not by MIF-1.

    abstract::The possible competition of MIF-1 (Pro-Leu-Gly-NH2) with 3H-naloxone or 3H-D-Ala-D-Leu-enkephalin (DADLE) for mu and delta opiate receptors in the rat striatum was examined under conditions of varying temperatures and concentrations of sodium and GTP. MIF-1, in concentrations ranging from 10(-14) to 10(-3) M, failed t...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(81)90117-9

    authors: Luciano MG,Zadina JE,Kastin AJ,Coy DH

    更新日期:1981-12-01 00:00:00

  • Involvement of endogenous opioids and ATP-sensitive potassium channels in the mediation of apomorphine-induced antinociception at the spinal level: a study using EMG planimetry of flexor reflex in rats.

    abstract::The effects of intrathecally (i.t.) administered naloxone or glibenclamide, a blocker of adenosine triphosphate-sensitive potassium (KATP) channels, on the antinociception produced by i.t. apomorphine were observed by an integrated electromyogram measurement of hindlimb flexor reflex in lightly pentobarbital-anestheti...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(99)00002-7

    authors: Hu WM,Kang YM,Qiao JT

    更新日期:1999-02-01 00:00:00

  • Reciprocal thalamo-hippocampal EEG augmenting and muscle responses in rabbits.

    abstract::Waxing and waning electrographic responses (augmenting) and primary evoked responses could be induced in restricted regions of hippocampus, thalamus, and skeletal muscle by bipolar, low-frequency (7-10 Hz), low-amplitude (35 mV-4V) stimulation of selected sites within the hippocampus or thalamus of rabbits. Induction ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(77)90003-x

    authors: Palmer MR,Klemm WR

    更新日期:1977-03-01 00:00:00