Abstract：
:Tolperisone is a voltage gated sodium channel blocker, centrally acting muscle relaxant drug, with a very advantageous side effect profile. Like other sodium channel blockers, it has weak affinity to the resting state and high affinity to the open/inactivated state of the channel. In this paper, its effect on BOLD responses in rat brain were elucidated both on the resting brain and paw stimulation evoked BOLD responses. Tolperisone did not exert any visible effect on resting brain, but strongly inhibited the paw stimulation evoked BOLD responses, showing somewhat higher efficacy in brain areas involved in pain sensation. This finding is in a good agreement with its sodium channel blocking profile. In the resting brain, most of the channels are in resting state. Electric train stimuli of the paw results in over activated neurons, where most sodium channels are in open or inactivated state. These data suggest that the very advantageous profile of tolperisone can be explained by its selective action on open or inactivated sodium channels of over-activated neurons in various brain regions rather than by a selective effect in the spinal cord as suggested previously.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Kocsis P,Gajári D,Deli L,Gőcze KZ,Pozsgay Z,Tihanyi Kdoi
10.1016/j.brainresbull.2013.09.008subject
Has Abstractpub_date
2013-10-01 00:00:00pages
34-40eissn
0361-9230issn
1873-2747pii
S0361-9230(13)00147-0journal_volume
99pub_type
杂志文章abstract：:The purinergic signaling system, including P2 receptors, plays an important role in various central nervous system (CNS) disorders. Over the last few decades, a substantial amount of accumulated data suggest that most P2 receptor subtypes (P2X1, 2, 3, 4, 6, and 7, and P2Y1, 2, 6, 12, and 13) regulate neuronal/neurogli...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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更新日期：2019-09-01 00:00:00
abstract：:Several hypotheses have been proposed to explain why some neurological patients fail to recognise objects from unusual views: that it results from difficulty identifying an object's principal axis when it is foreshortened, identifying an object when landmark features are occluded, or an inability to rotate mental imag...
journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(76)90080-0
更新日期：1976-11-01 00:00:00
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更新日期：2021-01-01 00:00:00
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doi：10.1016/s0361-9230(03)00042-x
更新日期：2003-05-15 00:00:00
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pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：Brain research bulletin
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doi：10.1016/j.brainresbull.2016.04.003
更新日期：2016-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-03-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0361-9230(02)00952-8
更新日期：2003-02-15 00:00:00
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pub_type： 杂志文章
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更新日期：2011-10-10 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.07.006
更新日期：2004-09-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/0361-9230(88)90174-8
更新日期：1988-02-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2007-10-19 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.07.009
更新日期：2008-11-25 00:00:00
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pub_type： 杂志文章
doi：10.1016/0361-9230(93)90124-t
更新日期：1993-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(87)90063-3
更新日期：1987-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-09-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1998-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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更新日期：1991-11-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2013.06.003
更新日期：2013-08-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2014.04.002
更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.brainresbull.2007.01.009
更新日期：2007-05-30 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1997-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2007.09.005
更新日期：2008-03-28 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2012.04.001
更新日期：2012-07-01 00:00:00
