Cytoarchitecture of nitrergic neurons in the human striatum and subthalamic nucleus.

Abstract:

BACKGROUND:Nitric oxide (NO) is a gaseous molecule that modulates several physiological processes, including signal transmission in the central nervous system. There is evidence supporting NO as a major neurotransmitter involved in motor and emotion/behavior control. We investigated the distribution and morphology of nitrergic neurons in the two main input structures of the basal ganglia of human brain: the striatum and subthalamic nucleus. METHODS:We studied samples of striatum (caudate and putamen) and subthalamic nucleus of 20 human brains from subjects without neurological/psychiatric diseases. The tissues were stained by histochemistry for nicotinamide adenine dinucleotide phosphate diaphorase activity and by immunohistochemistry for neuronal NO synthase (nNOS). Subsequently, we analyzed the nitrergic neuronal profile and its morphometric parameters. RESULTS:Our data corroborate that approximately 2% of neurons in striatum express nNOS and these exhibited morphology characteristic of interneurons. Posterior regions of the striatum have a higher nitrergic neuronal profile than anterior regions of this nucleus suggesting an anteroposterior gradient of nitrergic neurons. Posterior limbic-associated areas of the striatum have a higher nitrergic neuronal profile compared to other functional subdivisions. Also, approximately 90% of neurons in the subthalamic nucleus express nNOS. CONCLUSIONS:A remarkable presence of nitrergic neurons in the human striatum and subthalamic nucleus suggests that NO may play a critical role in the physiology of these nuclei.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Santos-Lobato BL,Del-Bel E,Pittella JE,Tumas V

doi

10.1016/j.brainresbull.2016.04.003

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

129-35

eissn

0361-9230

issn

1873-2747

pii

S0361-9230(16)30077-6

journal_volume

124

pub_type

杂志文章
  • Response inhibition failure to visual stimuli paired with a "single-type" stressor in PTSD patients: an fMRI pilot study.

    abstract::Patients with post-traumatic stress disorder (PTSD) tend to misinterpret innocuous stimuli as potential threats, possibly due to a conditioning provoked by traumatic episodes. Previous neuroimaging evidence has shown an abnormal activation of the amygdala and prefrontal cortex in PTSD patients during fear conditioning...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2015.03.001

    authors: Brunetti M,Sepede G,Ferretti A,Mingoia G,Romani GL,Babiloni C

    更新日期:2015-05-01 00:00:00

  • Histoenzymological mapping of alkaline phosphatase and 5-nucleotidase in the medulla oblongata of a microchiropteran bat (Taphozous melanopogon Temminck).

    abstract::The contribution deals with the distribution of alkaline phosphatase and 5-nucleotidase in the medulla oblongata of Taphozous melanopogon (a Microchiroptera), for the first time. The main highlights of the study are: (1) Cranial nerve nuclei demonstrate intense activity of alkaline phosphatase, whereas except nucleus ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(79)90030-3

    authors: Hafiza B,Sood PP

    更新日期:1979-07-01 00:00:00

  • Role of the medial septal area on the cardiovascular, fluid and electrolytic responses to angiotensin II and cholinergic activation into the subfornical organ in rats.

    abstract::In the present study we investigated the effect of electrolytic lesion of the medial septal area (MSA) on the pressor and dipsogenic response to cholinergic activation and angiotensin II (ANGII) injection into the subfornical organ (SFO) in rats. In addition the effect of MSA lesion on the natriuresis, kaliuresis and ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(94)90191-0

    authors: Colombari DS,Haibara AS,Camargo LA,Saad WA,Renzi A,DeLuca LA Jr,Menani JV

    更新日期:1994-01-01 00:00:00

  • Infant rats: hypothalamic unit activity.

    abstract::Single-unit recordings were made from lateral hypothalamic area (LHA) neurons of infant (8 through 21 days of age) male and female albino rats. Basal (or spontaneous) firing rates of LHA neurons were recorded for 20 min from rats 8 through 21 days of age, and mean basal firing rates did not differ across ages. Basal f...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(76)90081-2

    authors: Almli CR,McMullen NT,Golden GT

    更新日期:1976-11-01 00:00:00

  • Beta-endorphin injected into the nucleus of the raphe magnus facilitates metastatic tumor growth.

    abstract::Electrical stimulation of the periaqueductal gray of the rat's midbrain analgesia leads to an increase in the number of artificial pulmonary metastases from the Walker 256 tumor. In an effort to investigate the influence of the pain suppression system and its associated peptides on this phenomenon, we activated the pa...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(84)90164-3

    authors: Simon RH,Arbo TE,Lundy J

    更新日期:1984-05-01 00:00:00

  • Delayed visual maturation in infants: a disorder of figure-ground separation?

    abstract::Delayed visual maturation (DVM) is characterised by visual unresponsiveness in early infancy, which subsequently improves spontaneously to normal levels. We studied the optokinetic response and recorded pattern reversal VEPs in six infants with DVM (aged 2-4 months) when they were at the stage of complete visual unres...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(96)00128-1

    authors: Harris CM,Kriss A,Shawkat F,Taylor D,Russell-Eggitt I

    更新日期:1996-01-01 00:00:00

  • The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat.

    abstract::The organization of projection neurons in the ventral tegmental area (VTA), and in adjacent parts of the raphe nuclei medial to it (the central and rostral linear, and interfascicular nuclei), the mammillary body (the supramammillary region and the tuberomammillary nucleus), and the substantia nigra have been examined...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(82)90145-9

    authors: Swanson LW

    更新日期:1982-07-01 00:00:00

  • Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells.

    abstract::Fipronil, a GABA(A) receptor antagonist, is replacing many insecticide uses formerly fulfilled by organophosphates like chlorpyrifos. Few studies have addressed the potential for fipronil to produce developmental neurotoxicity. We compared the neurotoxicity of fipronil and chlorpyrifos in undifferentiated and differen...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2008.09.020

    authors: Lassiter TL,MacKillop EA,Ryde IT,Seidler FJ,Slotkin TA

    更新日期:2009-03-30 00:00:00

  • Altered conditioned taste aversion and glucose utilization in related brain nuclei of diabetic GK rats.

    abstract::The impact of diabetes and especially hyperglycemia on brain glucose utilization and insulin binding are still not clear. This is probably due to the fact that most studies have been performed in streptozotocin treated rats that are highly hyperglycemia and that could have an effect per se on the brain. The aim of the...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(95)00060-r

    authors: Marfaing-Jallat P,Portha B,Pénicaud L

    更新日期:1995-01-01 00:00:00

  • Cellular mechanisms of hypoxic injury in the developing brain.

    abstract::The susceptibility of the developing brain to hypoxia should depend on the lipid composition of the brain cell membrane; the rate of lipid peroxidation; the presence of antioxidant defenses; and the development and modulation of the excitatory neurotransmitter receptors such as the N-methyl-D-aspartate (NMDA) receptor...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/s0361-9230(98)00170-1

    authors: Mishra OP,Delivoria-Papadopoulos M

    更新日期:1999-02-01 00:00:00

  • Nature of salivation produced by thyrotropin-releasing hormone (TRH).

    abstract::In the unanesthetized cat, TRH was injected into the cerebral ventricles (ICV) through chronically implanted cannulae and the nature of the evoked salivation was investigated. TRH injected in doses from 0.1 to 1.0 mg evoked salivation which was not dose-dependent. The antimuscarinic drug atropine as well as the gangli...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(87)90021-9

    authors: Beleslin DB,Jovanovic-Micic D,Tomic-Beleslin N

    更新日期:1987-03-01 00:00:00

  • Effects of stimulus presentation rate on the activity of primary somatosensory cortex: a functional magnetic resonance imaging study in humans.

    abstract::To investigate the effect of stimulus presentation rate on the activity of primary somatosensory cortex, we performed echo-planar functional magnetic resonance imaging using a 1.5-tesla magnetic resonance system. Eight right-handed normal volunteers underwent functional magnetic resonance imaging during somatosensory ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(01)00438-5

    authors: Takanashi M,Abe K,Yanagihara T,Oshiro Y,Watanabe Y,Tanaka H,Hirabuki N,Nakamura H,Fujita N

    更新日期:2001-01-15 00:00:00

  • Different effects of unilateral and bilateral lesions of the dorsal raphe nucleus on puberty and first ovulation.

    abstract::The effects of unilateral and bilateral electrolytic lesions of the dorsal raphe nuclei (DRN) of 30-day-old rats, on the spontaneous and induced ovulation, were analyzed. The bilateral lesion and the lesion on the right side of the DRN delayed the age of first vaginal estrous. None of the animals with bilateral lesion...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(94)90182-1

    authors: Ayala ME,Rosas P,Dominguez R

    更新日期:1994-01-01 00:00:00

  • Primary culture of neurons derived from the adult mammalian brain.

    abstract::A method is described for the isolation and culture of neurons in the adult mammalian brain. The cell could be maintained in primary culture for more than several weeks. Whereas the neurons freshly dissociated from the adult brain did not respond to any of the neurotransmitter substances applied, the neurons regained ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(91)90058-r

    authors: Ogata N,Tatebayashi H

    更新日期:1991-11-01 00:00:00

  • Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice.

    abstract::In people with Huntington's disease, an expanded CAG repeat sequence on the HTT gene confers a toxic gain function resulting in a progressive and fatal neurodegeneration. The Hdh((CAG)Q150) Huntington's disease mouse line is a knock-in model of the disease that carries ∼150 CAG repeats on the normal mouse Htt locus. T...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2010.05.004

    authors: Brooks S,Higgs G,Jones L,Dunnett SB

    更新日期:2012-06-01 00:00:00

  • Direct hypothalamic control of vasoactive intestinal peptide (VIP) levels in the developing rat ovary.

    abstract::We have previously identified the neurotransmitter vasoactive intestinal peptide (VIP) in nerve fibers of the immature rat ovary and showed that it stimulates steroid release by a mechanism involving increased synthesis of the components of the cholesterol side-chain cleavage enzyme complex. The present experiments we...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(89)90077-4

    authors: Advis JP,Ahmed CE,Ojeda SR

    更新日期:1989-04-01 00:00:00

  • A stereotaxic atlas of the grey lesser mouse lemur brain (Microcebus murinus).

    abstract::In response to the growing interest in the prosimian Microcebus murinus for studies on cerebral aging, the stereotaxic atlas of its brain was carried out in view of further anatomical, biochemical, electrophysiological, and behavioral investigations as well as for therapeutic experiments. This primate, which could be ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(97)00458-9

    authors: Bons N,Silhol S,Barbié V,Mestre-Francés N,Albe-Fessard D

    更新日期:1998-05-01 00:00:00

  • The role of Nogo-A in neuroregeneration: a review.

    abstract::Nogo, also known as Reticulon-4, is a protein that is specific to the central nervous system (CNS), and has been identified as an inhibitor of neurite outgrowth. Nogo-A is the largest member of the Nogo family and is responsible for inhibition of CNS regeneration. The structural information and biological functions of...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainresbull.2012.02.011

    authors: Wang T,Xiong JQ,Ren XB,Sun W

    更新日期:2012-04-10 00:00:00

  • Transduction efficiency of AAV 2/6, 2/8 and 2/9 vectors for delivering genes in human corneal fibroblasts.

    abstract::In the present study, cellular tropism and relative transduction efficiency of AAV2/6, AAV2/8 and AAV2/9 vectors have been tested for the cornea using primary cultures of human corneal fibroblasts. The AAV6, AAV8 and AAV9 serotypes having AAV2 ITR plasmid encoding for alkaline phosphatase (AP) gene were generated by t...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2009.07.005

    authors: Sharma A,Ghosh A,Hansen ET,Newman JM,Mohan RR

    更新日期:2010-02-15 00:00:00

  • Tryptophan increases extracellular serotonin in the lateral hypothalamus of food-deprived rats.

    abstract::Although it is well established that increases in tryptophan availability can increase brain serotonin synthesis, the effect of tryptophan loads on serotonin release is not as clear. We have used in vivo microdialysis in order to monitor extracellular serotonin in the lateral hypothalamus to examine this issue. Trypto...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(90)90174-x

    authors: Schwartz DH,Hernandez L,Hoebel BG

    更新日期:1990-12-01 00:00:00

  • The conduction velocity and central projections of retinofugal fibers in the rabbit.

    abstract::IN anesthetized and paralyzed rabbits, action potentials were elicited antidromically following electrical stimulation of optic tract terminals at the geniculate level (LGN). The conduction velocity spectrum extended from 7 m.s-1 to 34 m.s-1. The distribution of conduction velocities indicated four major modes at 10, ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(80)90207-5

    authors: Molotchnikoff S,Lessard I

    更新日期:1980-11-01 00:00:00

  • Somatic labeling of the medial terminal nucleus of the accessory optic system with WGA-HRP injected into the rat occipital cortex.

    abstract::Neuronal cell bodies in the medial terminal nucleus of the accessory optic system (MTN) were labeled with WGA-HRP which was injected ipsilaterally into the occipital cortex in the rat. We suggest that the label was first transported anterogradely to the pretectal nucleus of the optic tract, then moved transneuronally ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(87)90043-8

    authors: Takada M,Li ZK,Hattori T

    更新日期:1987-01-01 00:00:00

  • Molecular and cellular mechanisms of opiate action: studies in the rat locus coeruleus.

    abstract::We have studied the molecular and cellular mechanisms underlying the acute and chronic effects of opiate on neurons of the rat locus coeruleus (LC). Acutely, opiates inhibit LC neurons by activating K+ channels and inhibiting a novel sodium-dependent inward current. Both of these actions are mediated via pertussis tox...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/0361-9230(94)90166-x

    authors: Nestler EJ,Alreja M,Aghajanian GK

    更新日期:1994-01-01 00:00:00

  • NMDA receptor activity in learning spatial procedural strategies I. The influence of hippocampal lesions.

    abstract::To acquire knowledge about the environment two types of learning are necessary: declarative localizatory learning about where environmental cues and the subject are, and procedural learning about how to explore and move around the environment. Experimental data indicate that hippocampal regions are involved in spatial...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2006.06.006

    authors: Leggio MG,Federico F,Neri P,Graziano A,Mandolesi L,Petrosini L

    更新日期:2006-10-16 00:00:00

  • Rat brain melanin at different ages and after various treatments.

    abstract::Melanin was measured by a spectrophotofluorometric method in the brains of albino rats from birth to 20 months of age. The concentration of brain melanin increased from Day 1 until adult levels were reached at 1 month. Between 1 and 20 months of age no significant differences were found in brain melanin. Daily injecti...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(79)90014-5

    authors: Kastin AJ,Kuzemchak B,Schally AV,Eggert MW Jr

    更新日期:1979-11-01 00:00:00

  • Blockade of stress-induced prolactin release in monosodium glutamate-treated rats.

    abstract::To elucidate the role of the medial basal hypothalamus (MBH) in stress-induced prolactin (Prl) release, adult male rats which had received monosodium glutamate (MSG 4 mg/g) on alternate days for the first 10 days of life were subjected to ether stress for 2 min. Blood samples were drawn at 0, 15, 30 and 60 min after e...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(83)90068-0

    authors: Mizunuma H,Khorram O,McCann SM

    更新日期:1983-01-01 00:00:00

  • Adolescent chronic variable social stress influences exploratory behavior and nicotine responses in male, but not female, BALB/cJ mice.

    abstract::Anxiety disorders and nicotine use are significant contributors to global morbidity and mortality as independent and comorbid diseases. Early-life stress, potentially via stress-induced hypothalamic-pituitary-adrenal axis (HPA) dysregulation, can exacerbate both. However, little is known about the factors that predisp...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2017.08.001

    authors: Caruso MJ,Reiss DE,Caulfield JI,Thomas JL,Baker AN,Cavigelli SA,Kamens HM

    更新日期:2018-04-01 00:00:00

  • Triplet repeats, RNA secondary structure and toxic gain-of-function models for pathogenesis.

    abstract::Ten years after the discovery of human diseases caused by trinucleotide repeat expansions, searching for mechanistic links between gene mutation and pathological phenotype remains a fundamental and unsolved issue. Evidence accumulated so far indicates that the pathogenesis of repeat disorders is complex and multi-fact...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/s0361-9230(01)00651-7

    authors: Galvão R,Mendes-Soares L,Câmara J,Jaco I,Carmo-Fonseca M

    更新日期:2001-10-01 00:00:00

  • Vestibulotrigeminal pathways in the frog, Rana esculenta.

    abstract::The aim of this study was to investigate whether primary vestibular afferent fibers establish direct connections with the motor and sensory trigeminal system in the brainstem of the frog. The experiments were carried out on Rana esculenta. In anaesthetized animals the trigeminal and vestibular nerves were prepared, an...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2007.10.049

    authors: Matesz C,Kovalecz G,Veress G,Deák A,Rácz E,Bácskai T

    更新日期:2008-03-18 00:00:00

  • Morphine and GABA: effects on perception, escape response and long-term habituation to a danger stimulus in the crab Chasmagnathus.

    abstract::Prior results (37) showed that morphine pretreatment reduces the escape response of the crab Chasmagnathus to a shadow passing overhead and prevents the acquisition of a long-term habituation. These results were explained by a reduction in the danger signalled by the stimulus, and to test this hypothesis methods other...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(91)90163-e

    authors: Tomsic D,Maldonado H,Rakitin A

    更新日期:1991-05-01 00:00:00