当前位置： SCI文献检索 > BRAIN RESEARCH BULLETIN期刊下所有文献 > Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: an autoradiographic study.

Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: an autoradiographic study.

Abstract：

:Depression is a brain disorder and there is still only a partial understanding of its underlying pathophysiology. Antidepressant medications with a fast onset have not yet been developed. In addition to the monoaminergic systems, the brain glutaminergic system has been implicated in the etiology of depression. Animal studies of depression have gained importance because they permit a more invasive manipulation of the subjects than human studies. In the present study, we measured the densities of the brain regional metabotropic glutaminergic receptor 5 (mGluR5) in the Flinders Sensitive Line (FSL) rat model of depression and two groups of control rats, the Flinders Resistant Line (FRL) and Sprague Dawley (SPD), the parent strain for both the FSL and FRL rats. The FSL rats showed lower densities of mGluR5 in many brain regions compared to either the SPD and/or FRL rats. In addition, the densities in the FRL rats were larger than in the SPD rats, suggesting possible problems in using FRL rats as controls. The presented data suggest that mGluR5 is lower in animal models of depression which could be related to the cognitive and emotional dysfunctions in the FSL rat model of depression and could be relevant to a better understanding of depression in humans.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Kovačević T,Skelin I,Minuzzi L,Rosa-Neto P,Diksic M

doi

10.1016/j.brainresbull.2012.01.010

subject

Has Abstract

pub_date

2012-03-10 00:00:00

pages

406-12

issue

4-5

eissn

0361-9230

issn

1873-2747

pii

S0361-9230(12)00011-1

journal_volume

87

pub_type

杂志文章

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