Abstract:
:This work is the second of a series of papers in which we investigated the neurophysiological basis of deep brain stimulation (DBS) clinical efficacy using post-operative local field potential (LFP) recordings from DBS electrodes implanted in the subthalamic nucleus (STN) in patients with Parkinson's disease. We found that low-frequency (1-1.5Hz) oscillations in LFP recordings from the STN of patients with Parkinson's disease dramatically increase after DBS of the STN itself (log power change=0.93+/-0.62; Wilcoxon: p=0.0002, n=13), slowly decaying to baseline levels after turning DBS off. The DBS-induced increase of low-frequency LFP oscillations is highly reproducible and appears only after the delivery of DBS for a time long enough to induce clinical improvement. This increase of low-frequency LFP oscillations could reflect stimulation-induced modulation of network activity or could represent changes of the electrochemical properties at the brain-electrode interface.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Priori A,Ardolino G,Marceglia S,Mrakic-Sposta S,Locatelli M,Tamma F,Rossi L,Foffani Gdoi
10.1016/j.brainresbull.2006.08.015subject
Has Abstractpub_date
2006-12-11 00:00:00pages
149-54issue
1-3eissn
0361-9230issn
1873-2747pii
S0361-9230(06)00255-3journal_volume
71pub_type
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