A study of creatine kinase reaction in rat brain under chronic pathological conditions-chronic ischemia and ethanol intoxication.

Abstract:

:Creatine kinase reaction rates were measured by the magnetisation transfer technique in brains of healthy adult and aged rats and in rats with chronic cerebral ischemia and chronic ethanol intoxication. These measurements indicated that the rate constant of the creatine kinase reaction is significantly reduced in the case of severe chronic cerebral ischemia in aged rats. In the adult rats, during chronic ethanol intoxication after 3 weeks of administration of 3 ml of 30% ethanol once a day via a gastric tube, a significant decrease in the pseudo first-order rate constant k(for) of the creatine kinase reaction was also found. In contrast, mild chronic cerebral ischemia in adult rats produced an increase in the reaction rate 4 weeks after occlusion. At the same time, corresponding conventional phosphorus magnetic resonance spectra showed negligible changes in signal intensities.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Kasparová S,Dobrota D,Mlynárik V,Pham TN,Liptaj T,Horecký J,Braunová Z,Gvozdjáková A

doi

10.1016/s0361-9230(00)00405-6

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

431-5

issue

4

eissn

0361-9230

issn

1873-2747

pii

S0361-9230(00)00405-6

journal_volume

53

pub_type

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