Abstract：
:In order to examine the effect of chronic neuroleptics on spinal dopaminergic system, rats were treated with haloperidol (0.5 mg/kg IP) for 21 days and the monosynaptic mass reflex (MMR) as well as dopamine (DA) metabolism were investigated. MMR, recorded from ventral root L6 following supramaximal stimulation to ipsilateral dorsal root L6 in spinalized rats, were found to be unaffected following chronic haloperidol treatment when compared to control. Apomorphine (0.1 mg/kg IV) caused 10-20% depression of MMR in control animals which was augmented to 40-50% in chronically haloperidol-treated animals suggesting an upregulation of DA receptors in the spinal cord. DA content of lumbar region of the spinal cord was unaffected whereas its major metabolite, homovanillic acid, was significantly reduced in chronic haloperidol-treated animals. This decreased utilization of DA may compensate the upregulation of DA receptors to maintain the physiological homeostasis of the spinal dopaminergic system.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Maitra KK,Seth P,Mohanakumar KP,Ganguly DKdoi
10.1016/0361-9230(92)90240-xkeywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
133-5issue
1eissn
0361-9230issn
1873-2747pii
0361-9230(92)90240-Xjournal_volume
28pub_type
杂志文章abstract：:The role of several hippocampal innervations in the sensitivity to barbital-induced narcosis was studied in selected mice strains. The outbred and inbred mouse strains HS/lgb, SABRA/HUC, C57BL, CBA/LAC, and BALB/c were tested for barbital-induced sleep (315 mg/kg). The relatively short sleeping HS/lbg (HS) and the lon...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(95)00077-r
更新日期：1995-01-01 00:00:00
abstract：:It is generally assumed that the primary response of the rat flash evoked potential (FEP) is activated by a retino-geniculate path, and that the secondary response reflects input to the cortex by way of the superior colliculus (SC) or other brainstem structures. In the present study, male Long-Evans rats were implante...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(86)90037-7
更新日期：1986-02-01 00:00:00
abstract：:The effect of environmental odors emanating from large-scale hog operations on the mood of nearby residents was determined using the POMS (Profile of Mood States). The scores for six POMS factors and the TMD (total mood disturbance score) for 44 experimental subjects were compared to those of 44 control subjects who w...
journal_title：Brain research bulletin
pub_type： 临床试验,杂志文章
doi：10.1016/0361-9230(95)00015-1
更新日期：1995-01-01 00:00:00
abstract：:The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for contr...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2003.12.005
更新日期：2004-03-01 00:00:00
abstract：:Together with its companion paper, dealing with the contribution of Luigi Galvani to the history of electrophysiology, this article provides a biographical sketch of the scientist of Bologna in the occasion of the bicentenary of his death. Studies on Galvani have focused mainly on his "discovery" of animal electricity...
journal_title：Brain research bulletin
pub_type： 传,历史文章,杂志文章
doi：10.1016/s0361-9230(98)00023-9
更新日期：1998-07-15 00:00:00
abstract：:The regeneration of brain tissue remains one of the greatest unsolved challenges in medicine and by many is considered unfeasible. Indeed, the adult mammalian brain does not regenerate tissue, but there is ongoing endogenous neurogenesis, which is upregulated after injury and contributes to tissue repair. This endogen...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2019.05.013
更新日期：2019-08-01 00:00:00
abstract：:The effects of intracerebroventricular (ICV) injection of neuropeptide Y (NPY) on parameters of dopamine (DA), glutamate (Glu) and gamma-aminobutyric acid (GABA) activities were investigated in the rat striatum. NPY (1.17-4.70 nmol) induced a dose-dependent increase in the striatal endogenous DA release monitored in f...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90178-z
更新日期：1992-02-01 00:00:00
abstract：:The present work describes a series of experiments designed to examine the possible role of central 5-HT circuits in the control of feeding and drinking in pigeons. Acute effects (within 1 h) of intracerebroventricular (ICV) injections of 5-HT (0, 9.7, 19.4, 38.7, 77.5, 155, and 310 nmol) in 24-h food-deprived (24FD) ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(97)00199-8
更新日期：1997-01-01 00:00:00
abstract：:On the basis of the evidence that approximately 45% of Schaffer collateral boutons are zinc-positive, zinc release from Schaffer collaterals and its action were examined in hippocampal slices. When zinc release from Schaffer collaterals was examined using ZnAF-2, a membrane-impermeable zinc indicator, ZnAF-2 signal in...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2005.10.001
更新日期：2006-02-15 00:00:00
abstract：:Serotonergic modulation of acetylcholine (ACh) release after neuron-specific increase of the expression of 5-HT(1B) receptors by gene transfer was studied in vitro and in vivo. The increased expression of the 5-HT(1B) receptor in vitro was induced by treating rat primary fetal septal cell cultures for 3 days with a vi...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.01.015
更新日期：2008-07-01 00:00:00
abstract：:Intractable scratching is the characteristic of chronic itch, which represents a great challenge in clinical practice. However, the mechanism underlying chronic itch development is largely unknown. In the present study, we investigated the role of NMDA receptor in acute itch and in development of chronic itch. A mouse...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2020.02.011
更新日期：2020-05-01 00:00:00
abstract：:Secondary brain injuries following intracerebral hemorrhage (ICH) are mediated by inflammatory pathway activation. The present study aimed to characterize long noncoding RNAs (lncRNAs) that are differentially expressed in cerebral tissues during ICH pathogenesis and to investigate their pathogenic functions. An ICH mo...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2020.04.017
更新日期：2020-09-01 00:00:00
abstract：:A computer program designed to be user friendly is described in this report. Two types of calculations are provided: a) determination of free calcium concentration based on known total salt concentration and b) those which calculate total salt concentration required to insure a desired free calcium concentration in th...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90088-f
更新日期：1992-09-01 00:00:00
abstract：:The purpose of this study was to determine whether elevated levels of 3,4-dihydroxyphenylacetic acid (DOPAC), the major metabolite of dopamine (DA) in the brain, could decrease the DA content in the striatum. Levels of DA were determined by high pressure liquid chromatography with electrochemical detection (HPLC-EC) i...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90161-p
更新日期：1992-12-01 00:00:00
abstract：:The serotonin(2A) (5HT(2A)) receptors have been shown to play an important role in several psychiatric disorders, including depression, schizophrenia, and alcoholism. This immunohistochemical study examined the cellular localization of 5HT(2A) receptors in various rat brain structures (olfactory, striatum, cortex, hip...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(99)00278-6
更新日期：2000-04-01 00:00:00
abstract：:Migraine and dizziness are relatively common disorders. Patients with dizziness have a higher incidence of migraines than the general population. The discomfort experienced by these patients is often poorly controlled by medication. However, the pathophysiology of vestibular migraine (VM) remains unclear. We hypothesi...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2015.06.005
更新日期：2015-07-01 00:00:00
abstract：:Regeneration following bilateral optic nerve crush was studied in groups of goldfish housed either on a standard diurnal cycle or under total light deprivation. Unoperated fish were included in each deprivation condition. Regeneration was only slightly delayed in the surgical group housed under light deprivation (68-8...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(82)90034-x
更新日期：1982-01-01 00:00:00
abstract：:We quantitatively analyzed the developing prospective neural and non-neural ectoderm during chicken gastrulation on semithin transverse sections. At stage PS8 (primitive streak stage 8 of Lopez-Sanchez et al. [C. Lopez-Sanchez, L. Puelles, V. Garcia-Martinez, L. Rodriguez-Gallardo, Morphological and molecular analysis...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2007.10.061
更新日期：2008-03-18 00:00:00
abstract：:This review focuses on the maturation of brain white-matter, as revealed by magnetic resonance (MR) imaging carried out in healthy subjects. The review begins with a brief description of the nature of the MR signal and its possible biological underpinnings, and proceeds with a description of MR findings obtained in ne...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/s0361-9230(00)00434-2
更新日期：2001-02-01 00:00:00
abstract：:Urethane is often used as a central anaesthetic in neurophysiological studies of drug effects. In this experiment, the effect of morphine on cortical EEG and single units of hippocampus and medial thalamus were compared in urethane-anaesthetized and paralyzed-awake rats. In each case, there was evidence of a morphine-...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(80)90183-5
更新日期：1980-03-01 00:00:00
abstract：:Mammals and birds are the only animals that exhibit high-amplitude slow-waves (SWs) in the electroencephalogram during sleep. The SWs that characterize slow-wave sleep (SWS) in mammals and birds reflect the large-scale synchronization of slow neuronal activity. In mammals, this synchronization is dependent upon the hi...
journal_title：Brain research bulletin
pub_type： 评论,杂志文章
doi：10.1016/j.brainresbull.2007.02.010
更新日期：2007-05-30 00:00:00
abstract：:Rat sciatic nerves were transected and placed in a solution of HRP. Following perfusion, L4-6 spinal segments and sensory ganglia were cut into 60 micron sections. Alternate sections were processed with the glucose oxidase (GOD) or the benzidine dihydrochloride (BDHC) procedure. Sections were then either mounted on gl...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(83)90154-5
更新日期：1983-04-01 00:00:00
abstract：:A newly developed technique employing the retrograde transport of horseradish peroxidase combined with immunocytochemistry is used to identify the cells of origin of descending spinal pathways and their putative neurotransmitters. With this technique the brainstem origins of descending serotonergic (5HT) pathways to t...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(82)90140-x
更新日期：1982-07-01 00:00:00
abstract：:Behavioral abnormalities have been reported in young and adult animals exposed to benzodiazepines prenatally. The presence of neurochemical alterations in the GABAergic system after prenatal benzodiazepine exposure was assessed in a chick model which avoids prenatal and postnatal maternal effects. The GABAA receptor c...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(89)90143-3
更新日期：1989-09-01 00:00:00
abstract：:Somatostatin immunoreactive (SOM-I) perikarya were first observed in the ventral horn at E12, in the presumptive intermediate gray area at E14, and in the alar plate of the rostral spinal cord at E14. In general, after their initial appearance, their density increased and then decreased during development. A moderate ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(88)90125-6
更新日期：1988-07-01 00:00:00
abstract：:The putative behavioral effects of the enantiomers of BAY K 8644 and the behavioral responses to (+/-)-BAY K 8644 following chronic injection were assessed on motor function in mice. The interaction of the enantiomers of BAY K 8644 with mouse brain dihydropyridine binding sites was also evaluated. The calcium channel ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(88)90019-6
更新日期：1988-12-01 00:00:00
abstract：:Cats pretreated with morphine (5 mg/kg, IP) received naloxone into the area of the locus coeruleus (LC) or the area of the substantia nigra (SN). The LC-treated animals stopped the morphine-induced stereotyped behavior and showed normal but hyperactive behavior. The SN-treated animals, however, ceased their movements ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(79)80006-4
更新日期：1979-05-01 00:00:00
abstract：:This study tested for the presence of androgen receptor-immunoreactivity in somatostatin, galanin, vasopressin, corticotropin-releasing hormone, and oxytocin neurons in the rat forebrain. The brains of adult male Sprague-Dawley rats were fixed with 4% paraformaldehyde. Androgen receptor was visualized in coronal secti...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90117-1
更新日期：1994-01-01 00:00:00
abstract：:To clarify the convergence of laryngeal afferents within the nucleus tractus solitarius (NTS) in the cat, we examined in the medulla the response characteristics of superior laryngeal nerve (SLN) fibers and NTS neurons to mechanical and chemical stimulation applied to laryngeal mucosa by extracellular recordings. The ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(95)00098-y
更新日期：1995-01-01 00:00:00
abstract：:The direct monosynaptic pathway which exists between vasoactive intestinal peptide (VIP) and GnRH neurons in the hypothalamic preoptic area provides a neuroanatomical background for the modulatory effects of VIP exerted on GnRH neurons activity. Though central microinjection of VIP revealed its involvement in the modu...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2005.07.007
更新日期：2005-10-30 00:00:00
