Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia.


:Although originally developed as a research tool for studying glial-glial and glial-axonal interactions, the technique of transplanting glial cell into the central nervous system has more recently been employed as a potential means for repairing persistent demyelination in clinical disease. It has now been clearly established using various experimental models that oligodendrocyte lineage cells, Schwann cells and olfactory ensheathing cells can all produce new myelin sheaths around demyelinated or amyelinated axons following transplantation. However, this property alone does not necessarily mean that transplantation of these cells into demyelinated lesions in clinical disease will be successful. This article considers some of the properties that would be required of a transplanted myelinogenic cell and assesses the advantages and disadvantages of the currently available cell types.


Brain Res Bull


Brain research bulletin


Franklin RJ





Has Abstract


2002-04-01 00:00:00














  • The teleostean forebrain: a comparative and developmental view based on early proliferation, Pax6 activity and catecholaminergic organization.

    abstract::An improved comparative interpretation of the teleostean forebrain suggests that the dorsal tier (Vd,Vc) and ventral tier (Vv,Vl) nuclei of the ventral telencephalic area (subpallium) represent the striatum and septum, respectively. Among other arguments, a dopaminergic innervation originating in the diencephalic post...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Wullimann MF,Rink E

    更新日期:2002-02-01 00:00:00

  • FGF9 knockout in GABAergic neurons induces apoptosis and inflammation via the Fas/caspase-3 pathway in the cerebellum of mice.

    abstract::Fibroblast growth factor 9 (FGF9) is a member of the fibroblast growth factor family and is widely expressed in the central nervous system (CNS). However, it is not clear how the working mechanism of FGF9 is involved in cerebellar development. To address this question, we deleted the Fgf9 gene specifically in GABAergi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Guo M,Chen H,Duan W,Li Z,Li Y,Ma Y,Xu X,Yi L,Bi Y,Liu Y,Zhang J,Li C

    更新日期:2020-01-01 00:00:00

  • Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats.

    abstract::The non-adenosine nucleoside guanosine (Guo) was demonstrated to decrease quinolinic acid(QA)-induced seizures, spontaneously emerged absence epileptic seizures and lipopolysaccharide(LPS)-evoked induction of absence epileptic seizures suggesting its antiepileptic potential. It was also described previously that intra...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Lakatos RK,Dobolyi Á,Todorov MI,Kékesi KA,Juhász G,Aleksza M,Kovács Z

    更新日期:2016-06-01 00:00:00

  • Driven to decay: Excitability and synaptic abnormalities in amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and brainstem MNs and the degeneration of the corticospinal tract. Degeneration of CSMNs and MNs leads inexorably to muscle wastage and weakness, ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Fogarty MJ

    更新日期:2018-06-01 00:00:00

  • Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1.

    abstract::Developmental malformations of cortex have been shown to co-occur with language, learning, and other cognitive deficits in humans. Rodent models have repeatedly shown that animals with such developmental malformations have deficits related to auditory processing and learning. More specifically, freeze-lesion induced m...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Threlkeld SW,McClure MM,Bai J,Wang Y,LoTurco JJ,Rosen GD,Fitch RH

    更新日期:2007-03-15 00:00:00

  • Motion sickness: a negative reinforcement model.

    abstract::Theories pertaining to the "why" of motion sickness are in short supply relative to those detailing the "how." Considering the profoundly disturbing and dysfunctional symptoms of motion sickness, it is difficult to conceive of why this condition is so strongly biologically based in humans and most other mammalian and ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Bowins B

    更新日期:2010-01-15 00:00:00

  • Phenotypic evaluation of a childhood-onset parkinsonism-dystonia mouse model with inherent postural abnormalities.

    abstract::Mouse models that replicate facets of human neurological diseases are often used at the pre-clinical stage to better understand the underlying mechanisms of a disease and test the target engagement of potential therapeutic interventions. We recently characterized a mouse model of childhood-onset parkinsonism-dystonia,...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Giraldo G,Janus C

    更新日期:2021-01-01 00:00:00

  • Blood -brain barrier disruption was less under isoflurane than pentobarbital anesthesia via a PI3K/Akt pathway in early cerebral ischemia.

    abstract::One of the important factors altering the degree of blood-brain barrier (BBB) disruption in cerebral ischemia is the anesthetic used. The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway has been reported to be involved in modulating BBB permeability and in isoflurane induced neuroprotection. This study was perf...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Chi OZ,Mellender SJ,Kiss GK,Liu X,Weiss HR

    更新日期:2017-05-01 00:00:00

  • Altered conditioned taste aversion and glucose utilization in related brain nuclei of diabetic GK rats.

    abstract::The impact of diabetes and especially hyperglycemia on brain glucose utilization and insulin binding are still not clear. This is probably due to the fact that most studies have been performed in streptozotocin treated rats that are highly hyperglycemia and that could have an effect per se on the brain. The aim of the...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Marfaing-Jallat P,Portha B,Pénicaud L

    更新日期:1995-01-01 00:00:00

  • High dose simvastatin and rosuvastatin impair cognitive abilities of healthy rats via decreasing hippocampal neurotrophins and irisin.

    abstract:BACKGROUND:Statins are cholesterol lowering drugs that decrease the risk of cardiovascular events, but they are related with a few unfavorable symptoms in skeletal muscle including myopathy, and mild to moderate fatigue. Additionally, there has been discrepancies about the impacts of statins on brain and cognition. Thi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Okudan N,Belviranli M

    更新日期:2020-12-01 00:00:00

  • Monoamine innervation of the forebrain: collateralization.

    abstract::The forebrain is characterized by a dense, localized dopamine (DA) innervation pattern, a diffuse, widespread norepinephrine (NE) innervation pattern, and a serotonin (5-HT) innervation intermediate between the DA and NE patterns. These innervation patterns have implied that basic differences exist in the way DA, NE a...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Fallon JH,Loughlin SE

    更新日期:1982-07-01 00:00:00

  • Does hypnotizability modulate the stress-related endothelial dysfunction?

    abstract::Previous studies suggest that hypnotizability represents a protective factor against the cardiac effects of cognitive stress and that hypnosis prevents vascular stress-induced modifications in highly hypnotizable individuals. The aim of the experiment was to investigate whether a similar effect at vascular level is pr...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Jambrik Z,Santarcangelo EL,Ghelarducci B,Picano E,Sebastiani L

    更新日期:2004-04-30 00:00:00

  • Microarray assay of circular RNAs reveals cicRNA.7079 as a new anti-apoptotic molecule in spinal cord injury in mice.

    abstract::Traumatic spinal cord injury (SCI) can lead to motor disturbance, sensory deficit, or autonomic dysfunction. The role of circRNAs in the pivotal physiopathological processes of SCI has been demonstrated recently. However, no similar research has been performed to explore the circRNAs involved in apoptosis after SCI. T...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Yao Y,Wang J,He T,Li H,Hu J,Zheng M,Ding Y,Chen YY,Shen Y,Wang LL,Zhu Y

    更新日期:2020-11-01 00:00:00

  • 17 beta-Estradiol inhibits the production of dopamine by the tuberoinfundibular dopaminergic neurons of the male rat.

    abstract::Previous work in our laboratory suggests that the indirect stimulation of prolactin gene transcription observed in male rats between 3 and 6 h following estrogen injection results from an inhibition of dopamine release from the tuberoinfundibular dopaminergic neurons. To evaluate further the role of dopamine in the re...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Shaw-Bruha CM,Happe HK,Murrin LC,Rodriguez-Sierra JF,Shull JD

    更新日期:1996-01-01 00:00:00

  • Neuroprotective actions of taurine on hypoxic-ischemic brain damage in neonatal rats.

    abstract::Taurine is an abundant amino acid in the nervous system, which has been proved to possess antioxidation, osmoregulation and membrane stabilization. Previously it has been demonstrated that taurine exerts ischemic brain injury protective effect. This study was designed to investigate whether the protective effect of ta...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Zhu XY,Ma PS,Wu W,Zhou R,Hao YJ,Niu Y,Sun T,Li YX,Yu JQ

    更新日期:2016-06-01 00:00:00

  • Extracellular signal-regulated kinases mediate melittin-induced hypersensitivity of spinal neurons to chemical and thermal but not mechanical stimuli.

    abstract::Subcutaneous melittin injection causes central plasticity at the spinal level in wide-dynamic-range (WDR) neurons, which are hypersensitive to various nociceptive stimuli. Previous behavioral studies demonstrated that the mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinase 1/2(ERK1/2), p38 ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Li MM,Yu YQ,Fu H,Xie F,Xu LX,Chen J

    更新日期:2008-11-25 00:00:00

  • Anteroventral third ventricle (AV3V) lesion affects hypothalamic neuronal nitric oxide synthase (nNOS) expression following water deprivation.

    abstract::Neuronal nitric oxide synthase (nNOS) has been reported to be up-regulated in the hypothalamic supraoptic nucleus (SON) during dehydration which in turn could increase nitric oxide (NO) production and consequently affect arginine vasopressin (AVP) secretion. The anteroventral third ventricle (AV3V) region has strong a...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Aguila FA,Oliveira-Pelegrin GR,Yao ST,Murphy D,Rocha MJ

    更新日期:2011-10-10 00:00:00

  • Actions of epinephrine on neurons in the rat midbrain periaqueductal gray maintained in vitro.

    abstract::The effect of epinephrine (EPI) on the activity of 150 periaqueductal gray (PAG) neurons was examined using extracellular recordings in an in vitro slice preparation. Drop application of EPI inhibited 45%, excited 35%, and had no effect on 20% of PAG neurons. Both the excitatory and inhibitory effects of EPI were of l...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Jiang M,Chandler SD,Ennis M,Shipley MT,Behbehani MM

    更新日期:1992-12-01 00:00:00

  • Strain differences of dopamine receptor levels and dopamine related behaviors in rats.

    abstract::Here we have investigated whether differences in levels of dopamine D1-like, D2-like receptors, dopamine D3 receptors, and dopamine transporter could be related to behaviors such as immobility response and locomotion between Wistar rats and Sprague-Dawley rats. The levels of the dopamine receptors and transporter were...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Zamudio S,Fregoso T,Miranda A,De La Cruz F,Flores G

    更新日期:2005-04-30 00:00:00

  • Comparison of thalamic populations in mammals and birds: expression of ErbB4 mRNA.

    abstract::The expression of ErbB4 mRNA was examined in dorsal thalamic regions of chicks and rats. In rats, ErbB4 expression was observed in the habenular nuclei, the paraventricular nucleus, intermediodorsal nucleus, the central medial thalamic nucleus, the posterior nucleus, the parafascicular nucleus, the subparafascicular n...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Bruce LL,Kornblum HI,Seroogy KB

    更新日期:2002-02-01 00:00:00

  • The organization of the pretectal nuclei in the trout: a revision based on experimental holodogical studies.

    abstract::The neuronal tracer DiI was applied to different brain centers of the rainbow trout in order to study the connections of pretectal nuclei. Our results showed that some pretectal nuclei receive a direct projection from the contralateral retina: the parvocellular superficial pretectal nucleus, the central pretectal nucl...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Folgueira M,Anadón R,Yáñez J

    更新日期:2008-03-18 00:00:00

  • Periaqueductal gray neurons response to microiontophoretically injected morphine in naive and morphine-dependent rats.

    abstract::The attempt of this study was to investigate the direct effects of increasing doses of morphine on the neuronal activity of the periaqueductal gray in morphine-naive and morphine-dependent rats. The microiontophoresis technique was used for this purpose. The four different responses induced by morphine exhibited dose-...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Schurr A,Rigor BM,Ho BT,Dafny N

    更新日期:1981-06-01 00:00:00

  • Diminished central fatigue by inhibition of the L-system transporter for the uptake of tryptophan.

    abstract::Nagase genetically analbuminemic rats (NAR) were run to fatigue. Administration of branched chain amino acids (BCAA) before exhaustive exercise, resulted in a post-fatigue decreased tryptophan uptake (-22%, p < 0.05) and 5-hydroxytryptophan (5-HTP) uptake (-29%, p < 0.01) into the synaptosomes isolated from the striat...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Yamamoto T,Newsholme EA

    更新日期:2000-05-01 00:00:00

  • Injection of muscimol in the posterior hypothalamus reduces the PGE1-hyperthermia in the rat.

    abstract::The firing rate of the nerves innervating interscapular brown adipose tissue (IBAT), IBAT and colonic temperatures (TIBAT and Tc), heart rate, and oxygen (O2) consumption were monitored in urethane-anesthetized male Sprague-Dawley rats. These variables were measured for 40 min before (baseline values) and 40 min after...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Monda M,Amaro S,Sullo A,De Luca B

    更新日期:1995-01-01 00:00:00

  • Role of Pax6 in forebrain regionalization.

    abstract::Pax6 is a highly conserved transcription factor essential for the development of the eyes in vertebrate and invertebrate species. It is also required for normal development of many regions of the central nervous system, including the mammalian forebrain, hindbrain and spinal cord. In the forebrain, it is expressed in ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Manuel M,Price DJ

    更新日期:2005-09-15 00:00:00

  • Hippocampal theta activity in the acute precollicular rat.

    abstract::In eleven acute precollicular rats, cortical and hippocampal EEG activity was recorded. Hippocampal theta activity of low frequency (mean 4.5 c/sec) was found in nine rats and in four occupied above 50% of the recording time. In contrast, in the cortex the synchronized EEG activity dominated. The electrical stimulatio...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Gottesmann C,Gandolfo G,Zernicki B

    更新日期:1989-06-01 00:00:00

  • Chronic restraint stress impairs endocannabinoid mediated suppression of GABAergic signaling in the hippocampus of adult male rats.

    abstract::Chronic stress, a risk factor for the development of psychiatric disorders, is known to induce alterations in neuronal networks in many brain areas. Previous studies have shown that chronic stress changes the expression of the cannabinoid receptor 1 (CB1) in the brains of adult rats, but neurophysiological consequence...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Hu W,Zhang M,Czéh B,Zhang W,Flügge G

    更新日期:2011-07-15 00:00:00

  • Lipid rafts: keys to neurodegeneration.

    abstract::The increase in life expectancy seen in many countries has been accompanied by an increase in the number of people living with dementia and a growing need for health care. The large number of affected individuals emphasizes the need to identify causes for the phenotypes associated with diseases such as Alzheimer's, Pa...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Schengrund CL

    更新日期:2010-04-29 00:00:00

  • Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells.

    abstract::The antidepressant desipramine has been shown to decrease synaptic membrane concentrations of the norepinephrine re-uptake transporter (NET) in vivo and in vitro, on both an acute and a chronic basis. The possible contribution of decreased NET synthesis to the chronic downregulation of the NETs has not been definitive...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Zavosh A,Schaefer J,Ferrel A,Figlewicz DP

    更新日期:1999-07-01 00:00:00

  • Vagal nerve stimulation as a promising tool in the improvement of cognitive disorders.

    abstract::Vagal nerve stimulation (VNS) is known as an effective method of treatment in a number of neurological disorders. The low risk of side effects also makes it useful in clinical trials in other diseases. Branches of the vagal nerve innervate the anatomical structures known to be involved in memory processing. That is wh...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Broncel A,Bocian R,Kłos-Wojtczak P,Kulbat-Warycha K,Konopacki J

    更新日期:2020-02-01 00:00:00