Abstract：
:Nagase genetically analbuminemic rats (NAR) were run to fatigue. Administration of branched chain amino acids (BCAA) before exhaustive exercise, resulted in a post-fatigue decreased tryptophan uptake (-22%, p < 0.05) and 5-hydroxytryptophan (5-HTP) uptake (-29%, p < 0.01) into the synaptosomes isolated from the striatum when compared with saline administration. At the same time, NAR who received either BCAA or 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH, a specific inhibitor for the L-system transporter) had a considerably prolonged run time to exhaustion (by twofold), compared to those who received either saline or albumin treatments. When classified by run time, it was of interest that, when the data for BCAA and BCH treatments for the longer run time NAR (Group B) was combined, it gave rise to a significant decrease in synaptosomal tryptophan and 5-HTP of a similar magnitude to that observed with BCAA alone. These levels were lower than those observed in NAR in the shorter run time group (Group A) for all treatments. These results support the view that an activated serotonergic function may be involved in central fatigue, which can be diminished by inhibition of the L-system transporter.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Yamamoto T,Newsholme EAdoi
10.1016/s0361-9230(99)00276-2keywords:
subject
Has Abstractpub_date
2000-05-01 00:00:00pages
35-8issue
1eissn
0361-9230issn
1873-2747pii
S0361-9230(99)00276-2journal_volume
52pub_type
杂志文章abstract：:This study aimed to assess whether changes in the patterns of local field potential (LFP) oscillations of the subthalamic nucleus (STN) underlie to the clinical improvement within 60 s after turning off subthalamic DBS. We studied by spectral analysis the STN LFPs recorded in 13 nuclei from 7 patients with Parkinson's...
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0361-9230(90)90130-r
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.02.028
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更新日期：2018-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-11-15 00:00:00
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更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0361-9230(00)00410-x
更新日期：2001-01-01 00:00:00
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更新日期：1993-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0361-9230(85)90179-0
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pub_type： 杂志文章
doi：10.1016/0361-9230(87)90014-1
更新日期：1987-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-03-01 00:00:00
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1982-02-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(84)90054-6
更新日期：1984-03-01 00:00:00
abstract：:Genetic analysis aims to identify the variations in DNA sequence whose functional consequences produce heritable variations in phenotype. In one of the first successes of unbiased molecular genetic analysis in human disease, the Huntington's disease (HD) gene was mapped and cloned without any prior knowledge of the na...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2006.10.014
更新日期：2007-04-30 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2019.01.009
更新日期：2019-03-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(86)90051-1
更新日期：1986-03-01 00:00:00
