Progesterone receptor isoforms expression in the prepuberal and adult male rat brain.

Abstract:

:Progesterone receptor (PR) isoforms expression was determined in several regions of the prepuberal and adult male rat brain by using reverse transcription coupled to polymerase chain reaction. Rats under a 14:10-h light-dark cycle, with lights on at 0600 h were used. We found that in the hypothalamus of prepuberal animals the expression of both PR isoforms was similar, whereas PR-A expression was higher than that of PR-B in adults. In the cerebellum PR-B expression was predominant in both prepuberal and adult rats. In both ages PR-A and PR-B exhibited a non-significant tendency to be predominant in the hippocampus and the preoptic area respectively. In the frontal cortex and the olfactory bulb PR isoforms were expressed at a similar level. These results indicate a differential expression pattern of PR isoforms in the male rat brain and suggest that the tissue-specific expression of PR-A and PR-B is important for the appropriate response of each cerebral region to progesterone.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Guerra-Araiza C,Reyna-Neyra A,Salazar AM,Cerbón MA,Morimoto S,Camacho-Arroyo I

doi

10.1016/s0361-9230(00)00410-x

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

13-7

issue

1

eissn

0361-9230

issn

1873-2747

pii

S0361-9230(00)00410-X

journal_volume

54

pub_type

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