Abstract:
:Progesterone receptor (PR) isoforms expression was determined in several regions of the prepuberal and adult male rat brain by using reverse transcription coupled to polymerase chain reaction. Rats under a 14:10-h light-dark cycle, with lights on at 0600 h were used. We found that in the hypothalamus of prepuberal animals the expression of both PR isoforms was similar, whereas PR-A expression was higher than that of PR-B in adults. In the cerebellum PR-B expression was predominant in both prepuberal and adult rats. In both ages PR-A and PR-B exhibited a non-significant tendency to be predominant in the hippocampus and the preoptic area respectively. In the frontal cortex and the olfactory bulb PR isoforms were expressed at a similar level. These results indicate a differential expression pattern of PR isoforms in the male rat brain and suggest that the tissue-specific expression of PR-A and PR-B is important for the appropriate response of each cerebral region to progesterone.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Guerra-Araiza C,Reyna-Neyra A,Salazar AM,Cerbón MA,Morimoto S,Camacho-Arroyo Idoi
10.1016/s0361-9230(00)00410-xkeywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
13-7issue
1eissn
0361-9230issn
1873-2747pii
S0361-9230(00)00410-Xjournal_volume
54pub_type
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