Abstract:
:The effects of delta-9-tetrahydrocannabinol (delta-9-THC) on monosynaptic population responses in hippocampal CA1 pyramidal cells were examined in acute rats for several doses and at several post injection time periods. Delta-9-THC enhanced paired pulse inhibition in a dose-dependent manner; however biphasic dose effects were observed on cell responses during low frequency potentiation and on population spikes elicited by a conditioning stimulus. The biphasic responses were such that 2--4 mg/kg THC (IP) excited while 16 mg/kg depressed the stimulus elicited CA1 response. For low doses of THC slight biphasic time effects were observed. Evidence presented suggests that some of THC's actions on hippocampus may be due to direct or indirect actions on GABA-mediated activity.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Weisz DJ,Gunnell DL,Teyler TJ,Vardaris RMdoi
10.1016/0361-9230(82)90042-9subject
Has Abstractpub_date
1982-02-01 00:00:00pages
155-62issue
2eissn
0361-9230issn
1873-2747pii
0361-9230(82)90042-9journal_volume
8pub_type
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