Abstract:
:Spinal NMDA receptors contribute to control of the cardiovascular system by the ventrolateral medulla. However, little is known about the contribution of these receptors to suprabulbar regulation of hemodynamics and sympathetic outflow. Hence, the involvement of spinal NMDA receptors in regulation of the cardiovascular system by the paraventricular nucleus (PVN) of the hypothalamus was investigated. In urethane-anesthetized rats, the change in mean arterial pressure (MAP), heart rate (HR), and renal nerve activity (RNA) produced by electrical or chemical activation of the PVN was determined before and after intrathecal administration of the NMDA receptor antagonist, 2-amino-5-phosphonovaleric acid (AP5). Intrathecal AP5 decreased resting MAP, HR, and RNA, but had no effect on the increase in RNA produced by electrical or chemical stimulation of the PVN. The pressor and renal vasoconstrictor effects resulting from electrical, but not chemical, stimulation of the PVN were significantly reduced by intrathecal AP5. These data show that much of the cardiovascular control exerted by the PVN does not depend on a spinal NMDA receptor mechanism.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Porter JPdoi
10.1016/0361-9230(93)90169-csubject
Has Abstractpub_date
1993-01-01 00:00:00pages
653-60issue
6eissn
0361-9230issn
1873-2747pii
0361-9230(93)90169-Cjournal_volume
32pub_type
杂志文章abstract::In this study, we compared the depression-like symptoms induced by olfactory bulbectomy (OBX) in the two inbred Wistar and Long Evans rat strains. We also analyzed the self-regulated oral intake of nicotine in these strains and the effect of nicotine on the depression-like symptoms of olfactory bulbectomy. Furthermore...
journal_title:Brain research bulletin
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journal_title:Brain research bulletin
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更新日期:2019-04-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(98)00050-1
更新日期:1998-08-01 00:00:00
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更新日期:2018-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1989-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1984-05-01 00:00:00
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更新日期:2004-04-30 00:00:00
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更新日期:2018-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(89)90209-8
更新日期:1989-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.02.011
更新日期:2020-05-01 00:00:00
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更新日期:2000-07-15 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90050-t
更新日期:1991-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brainresbull.2017.03.007
更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90020-x
更新日期:1992-08-01 00:00:00
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更新日期:2002-08-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.11.005
更新日期:2009-03-16 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2005-03-15 00:00:00