Abstract：
:This paper provides an introduction to a special issue dedicated to the action of environmental estrogens on neural circuits and behavior. The problem of endocrine disrupting chemicals (EDCs), i.e. chemicals that have the capacity to interfere with the endocrine system, has gained increasing attention as it has become clear that these environmental contaminants may be active in humans, as well as in wildlife and domestic animal species. The majority of the early investigations were aimed at the discovery of the toxicological effects of the EDCs, but biomedical observations were among some of the first indications that estrogenic compounds may exert deleterious effects, even some time after exposure. The data derived from women exposed prenatally to diethylstilbesterol provided powerful evidence for long-term effects and endocrine disruption associated with selected compounds. The examination of wild animal populations exposed to industrial chemicals showed that the chemical exposure, though nonlethal, left the individual impaired or even incapable of reproducing. Among the multiple targets of the action of EDCs, several researches performed in recent years have investigated subtle modifications of the animal behaviors (reproductive, aggressive) that are likely to be related to alterations of specific neural pathways. We have, therefore, focused here on the behavioral studies as one of the more powerful tools to investigate EDCs effects on specific neural circuits.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Panzica GC,Viglietti-Panzica C,Ottinger MAdoi
10.1016/j.brainresbull.2005.01.007keywords:
subject
Has Abstractpub_date
2005-04-15 00:00:00pages
187-91issue
3eissn
0361-9230issn
1873-2747pii
S0361-9230(05)00033-Xjournal_volume
65pub_type
杂志文章,评审abstract：:The effect of pretreatment of geranylgeranylacetone (GGA), an inducer of heat shock protein (HSP) 70, on responses in sleep and core body temperature (Tcore) against sleep deprivation (SD) was examined in rats. After 3 days of GGA or vehicle injection, a 6-h period of SD was performed. During the recovery period, both...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2006.02.004
更新日期：2006-04-28 00:00:00
abstract：:The thiol reagent cysteamine was administered to adult male rats with the aim of investigating its effect on different neural and pineal components. As expected, immunoreactive somatostatin decreased in the median eminence (ME) (p less than 0.05) and gastric antrum (p less than 0.05) after cysteamine; however, no sign...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(86)90051-1
更新日期：1986-03-01 00:00:00
abstract：:Effects of the selective alpha 2-adrenoceptor agonist, medetomidine, on a compound volley of a tibial nerve stimulation-evoked spinal reflex, pain-induced phrenic motor responses and on postoperative neuropathic pain behavior were studied in rats. Medetomidine (0.3 mg/kg) decreased the amplitude of the compound volley...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)00245-v
更新日期：1995-01-01 00:00:00
abstract：:The Lurcher (Lc/+) mutant mouse is characterized by a considerable atrophy of the cerebellum due to a massive loss of cerebellar Purkinje and granule cells, as well as of neurons from the inferior olivary nucleus. In this study the effects of a therapeutic combination of amantadine, thiamine and L-tryptophan on the se...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(98)00164-6
更新日期：1999-01-15 00:00:00
abstract：:We have studied the effects of 14-methoxymetopon (HS 198), a potent opioid agonist, on the responses to the tail electric stimulation test and plus-maze activity of adult male rats. The prototype mu agonist morphine was used as the drug of reference. Besides we addressed the effects of HS 198 on the serum corticostero...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(01)00760-2
更新日期：2002-03-15 00:00:00
abstract：:The effect of serotonin synthesis inhibitor, p-chlorophenylalanine (PCPA), on induction and maintenance of pseudopregnancy as indicated by deciduoma formation was examined in female rats. Animals were injected with 1 mg/kg b.wt. of reserpine on the day of metestrus, and silk thread was passed through and placed in the...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(95)02117-5
更新日期：1996-01-01 00:00:00
abstract：:The expression of ErbB4 mRNA was examined in dorsal thalamic regions of chicks and rats. In rats, ErbB4 expression was observed in the habenular nuclei, the paraventricular nucleus, intermediodorsal nucleus, the central medial thalamic nucleus, the posterior nucleus, the parafascicular nucleus, the subparafascicular n...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(01)00678-5
更新日期：2002-02-01 00:00:00
abstract：:Stimulus-specific neuronal responses in the central auditory pathway of Psammomys obesus were studied with deoxyglucose autoradiography. Responses were revealed mainly in the inferior colliculus. With whole head sectioning and subsequent gentle freeze-drying, excellent structural preservation was achieved. With the us...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(84)90061-3
更新日期：1984-03-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90001-9
更新日期：1994-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(88)90019-6
更新日期：1988-12-01 00:00:00
abstract：:The possible involvement of basal telencephalic structures in visually conditioned heart rate change (established by pairing light and foot-shock) was studied in 156 pigeons by evaluating conditioning performance following lesions of the septum or lobus parolfactorius. Extensive destruction of the septal complex had n...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(78)90098-9
更新日期：1978-07-01 00:00:00
abstract：:Chronic exposure to drugs and alcohol leads to damage to dopaminergic neurons and their projections in the 'reward pathway' that originate in the ventral tegmental area (VTA) and terminate in the nucleus accumbens (NAc). This damage is thought to contribute to the signature symptom of addiction: chronic relapse. In th...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2015.11.008
更新日期：2016-05-01 00:00:00
abstract：:Prenatal exposure of mice to heroin (SC injection of 10mg/kg to the dams on gestational days 9-18) resulted at adulthood in behavioral deficits related to septohippocampal cholinergic innervation accompanied with both presynaptic and postsynaptic cholinergic hyperactivity; including an increase membrane PKC activity, ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.04.006
更新日期：2004-05-30 00:00:00
abstract：:In people with Huntington's disease, an expanded CAG repeat sequence on the HTT gene confers a toxic gain function resulting in a progressive and fatal neurodegeneration. The Hdh((CAG)Q150) Huntington's disease mouse line is a knock-in model of the disease that carries ∼150 CAG repeats on the normal mouse Htt locus. T...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2010.05.004
更新日期：2012-06-01 00:00:00
abstract：:A high correlation between alcohol use and smoking has long been suggested by epidemiological data. We examined the potential behavioral interactions between ethanol and nicotine using ethanol-induced motor incoordination as the test response in mice. Effect of pretreatment of various doses of (-)-nicotine, (-)-cotini...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(93)90314-2
更新日期：1993-01-01 00:00:00
abstract：:The primary objective of this study was to determine whether pretreatment with kappa- and delta-opioid agonists potentiates naltrexone-induced suppression of water consumption following 24h of deprivation. This study also examined the temporal effects of agonist-induced antinociception using the tail-flick and hot-pla...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.04.002
更新日期：2008-08-15 00:00:00
abstract：:Vagal nerve stimulation (VNS) is known as an effective method of treatment in a number of neurological disorders. The low risk of side effects also makes it useful in clinical trials in other diseases. Branches of the vagal nerve innervate the anatomical structures known to be involved in memory processing. That is wh...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2019.11.011
更新日期：2020-02-01 00:00:00
abstract：:In this study, we examine the utility of computational modeling in understanding nervous system function. We start by examining the reasons for, and major approaches to, computational modeling. We then chose a modeling approach and applied different variations to understanding nucleus tractus solitarius (NTS) neuronal...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/s0361-9230(99)00242-7
更新日期：2000-01-15 00:00:00
abstract：:Gamma-secretase (GS) is an enzyme complex that cleaves numerous substrates, and it is best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ) peptides. Aberrant cleavage of APP can lead to Alzheimer's disease, so much research has been done to better understand GS structure and function in ho...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2016.04.019
更新日期：2016-09-01 00:00:00
abstract：:We propose that separate sensory and hedonic representations exist in each of the primary structures of the somatosensory system, including brainstem, thalamic and cortical components. In the dorsal horn of the spinal cord, the hedonic representation, which consists primarily of nociceptive-specific, wide dynamic rang...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/s0361-9230(02)00783-9
更新日期：2002-07-01 00:00:00
abstract：:The role of the serotonergic transmission on the negative feedback of corticosterone on the pituitary-adrenal (PA) axis was studied in adult male rats. Animals were given p-chlorophenylalanine (PCPA) and 24 h later were administered corticosterone, 2 h before being subjected to 20 min of noise stress. The main results...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90212-g
更新日期：1992-06-01 00:00:00
abstract：:Cats pretreated with morphine (5 mg/kg, IP) received naloxone into the area of the locus coeruleus (LC) or the area of the substantia nigra (SN). The LC-treated animals stopped the morphine-induced stereotyped behavior and showed normal but hyperactive behavior. The SN-treated animals, however, ceased their movements ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(79)80006-4
更新日期：1979-05-01 00:00:00
abstract：:In the intact animal, some substantia nigra dopaminergic neurons exhibit regular, and some exhibit burst firing patterns. In the in vitro slice preparation, however, all dopaminergic neurons exhibit a nonburst firing pattern. Burst firing patterns are thought to be regulated, in part, by a small conductance calcium-ac...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90044-x
更新日期：1992-03-01 00:00:00
abstract：:Cellular and molecular mechanisms involved in the generation of seizures and the magnitude of neural cells injury are not fully understood. We evaluated astrocyte and/or neuronal injury in rats in the pentylenetetrazol model of acute seizures by measuring S100B and NSE levels in cerebrospinal fluid. Additionally, we d...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.07.006
更新日期：2004-09-30 00:00:00
abstract：:Horseradish peroxidase (HRP, Sigma Type VI) crystals were encased in a parafilm envelope and applied to the transected central ends of the left and right cervical vagus nerves and the anterior and posterior esophageal vagus nerves of adult male hooded rats. Injections of 30% HRP were made into the muscle wall of the f...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(84)90040-6
更新日期：1984-10-01 00:00:00
abstract：:Single-unit responses of preoptic-anterior hypothalamic (PO/AH) thermosensitive neurons to electrical stimulation of the mediobasal hypothalamus (MBH: ventromedial and arcuate nuclei) have been studied in urethane-anesthetized male rats. About half of thermosensitive neurons (46.4% of 69 warm-units and 50% of 28 cold-...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(82)90095-8
更新日期：1982-06-01 00:00:00
abstract：:Development and resolution of the lesion produced by occlusion of the middle cerebral artery (MCAO) was studied through quantitative planimetry and histologic/immunohistochemical techniques. MCAO, performed in spontaneously hypertensive rats (SHR), initially (1-3 days) produced large, consistent cerebral cortical infa...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(93)90124-t
更新日期：1993-01-01 00:00:00
abstract：:Autophagy is the lysosome-mediated bulk degradation of cellular components for material recycling to maintain cellular homeostasis. Autophagy was initially regarded as a nonselective process, however, recent evidence indicates that this process can in fact be highly selective, especially for targeting and degrading or...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2017.11.009
更新日期：2018-03-01 00:00:00
abstract：:Pretreatment with the 5-HT2 antagonist ketanserin and the 5-HT1A/2 antagonist spiperone did not reduce nicotine-induced hypomotility in mice, nor did MDL 7222, a selective 5-HT3 antagonist. In addition, 8-OH-DPAT and buspirone, 5-HT1A agonists, had no significant effects on nicotine-induced hypomotility. However, 8-OH...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90252-6
更新日期：1994-01-01 00:00:00
abstract：:Nogo, also known as Reticulon-4, is a protein that is specific to the central nervous system (CNS), and has been identified as an inhibitor of neurite outgrowth. Nogo-A is the largest member of the Nogo family and is responsible for inhibition of CNS regeneration. The structural information and biological functions of...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2012.02.011
更新日期：2012-04-10 00:00:00
