Negative feedback of corticosterone on the pituitary-adrenal axis is maintained after inhibition of serotonin synthesis with parachlorophenylalanine.

Abstract:

:The role of the serotonergic transmission on the negative feedback of corticosterone on the pituitary-adrenal (PA) axis was studied in adult male rats. Animals were given p-chlorophenylalanine (PCPA) and 24 h later were administered corticosterone, 2 h before being subjected to 20 min of noise stress. The main results were as follows: First, PCPA administration increased resting levels of both corticotropin (ACTH) and corticosterone but did not alter PA response to noise stress; second, ACTH response to stress was eliminated in rats given PCPA; third, corticosterone reduced ACTH levels in nonstressed rats only and this effect was maintained after PCPA administration. Taken together, the present results suggest a mediator role for serotonin in the noise-stress-induced PA hormone release but no role in the negative feedback of corticosterone on the PA axis.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Armario A,Martí O,Gavaldà A

doi

10.1016/0361-9230(92)90212-g

keywords:

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

915-8

issue

6

eissn

0361-9230

issn

1873-2747

pii

0361-9230(92)90212-G

journal_volume

28

pub_type

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