Abstract:
:Permanent cannulae for intracerebroventricular (ICV) infusion were implanted bilaterally in cats following stereotaxic procedures. After colonic temperature was recorded for a one-hour baseline, a 300 microliter ICV infusion was given of CSF control vehicle, 1:100 dilution of W3110 E. coli endotoxin (10(8) organisms/ml) or alpha-melanocyte-stimulating hormone (alpha-MSH) in one of seven doses ranging from 50.0 ng to 50.0 micrograms. Whereas ICV E. coli always induced an intense and prolonged fever of rapid onset, alpha-MSH infused similarly was essentially without effect on the deep body temperature of the normothermic cat. When each of the doses of alpha-MSH was infused ICV, either during the rising phase of an E. coli fever or after the febrile response had reached its asymptote, the core temperature of the cat was unaffected. Similarly, a mixture of E. coli combined with alpha-MSH given ICV failed to alter the characteristics of the rapidly developing fever produced in the cat by this endotoxin. On the other hand, either excess Ca++ ions (50 mM) given ICV or the antipyretic drug. Dipyrone, administered systematically during the course of an endotoxin fever effectively attenuated the animal's elevated body temperature. These results demonstrate that alpha-MSH is apparently neither involved in the central mechanisms underlying normal thermoregulation, nor does it act as an endogenous antipyretic in the cat as has been postulated in another species.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Rezvani AH,Denbow DM,Myers RDdoi
10.1016/0361-9230(86)90017-1subject
Has Abstractpub_date
1986-01-01 00:00:00pages
99-105issue
1eissn
0361-9230issn
1873-2747pii
0361-9230(86)90017-1journal_volume
16pub_type
杂志文章abstract::Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly understood; current nosological concepts are largely based on these molecular signatures of protein aggregates which also provide valua...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
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doi:10.1016/s0361-9230(00)00362-2
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2019.11.009
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2009-05-29 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2007.05.004
更新日期:2007-09-14 00:00:00
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journal_title:Brain research bulletin
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更新日期:1993-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
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更新日期:2017-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(81)80050-0
更新日期:1981-03-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2006-12-11 00:00:00
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.11.019
更新日期:2021-02-01 00:00:00
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
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更新日期:2001-12-01 00:00:00
abstract::Pax6 is an important transcription factor expressed in several discrete domains of the developing central nervous system. It has been reported that Pax6 is involved in the specification of subtypes of hindbrain motor neurons. Pax6 homozygous mutant (rSey2/rSey2) rats die soon after birth, probably due to impaired resp...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2019.07.007
更新日期:2019-10-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and brainstem MNs and the degeneration of the corticospinal tract. Degeneration of CSMNs and MNs leads inexorably to muscle wastage and weakness, ...
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pub_type: 杂志文章,评审
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更新日期:2018-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90099-0
更新日期:1983-03-01 00:00:00
abstract::Previous studies using a pharmacological approach suggested a neural pathway emanating from the periaqueductal gray (PAG) to the nucleus accumbens relevant to antinociception. This was investigated with neurochemical and histochemical methods in the present study. Push-pull perfusion and radioimmunoassay were used to ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90215-j
更新日期:1992-06-01 00:00:00
abstract::The role of alpha-2 adrenoceptors in the milk-ejection reflex was investigated by making electrophysiological recordings from oxytocin neurones in the supraoptic nucleus of urethane-anaesthetised rats. Systemic administration of the alpha-2 adrenoceptor antagonist. Idazoxan (0.5 mg/kg, i.v.), temporarily suppressed OT...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(97)00115-9
更新日期:1997-01-01 00:00:00
abstract::During a single-step visual tracking task of monkeys, parametric changes of the wrist extension-flexion movement and related discharge rate changes of pyramidal tract neurons (PTNs) of hand-arm motor area were studied. The task consisted of preparatory, precontraction, contraction and target periods. If the displaceme...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(79)90289-2
更新日期:1979-03-01 00:00:00
abstract::A high proportion of patients who have suffered a stroke also suffer from aphasia. Approximately half of those affected will remain in this state despite intensive language therapy. Non-invasive brain stimulation allows us to directly and focally stimulate areas of the brain. Repetitive transcranial magnetic stimulati...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2013.07.005
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To establish a link between tryptophan (a precursor for 5-hydroxytryptamine (5-HT) or serotonin, involved in sleep and fatigue) and post-operative fatigue after major surgery. BACKGROUND:There is a link between tryptophan (the precursor for the neurotransmitter 5-hydroxytryptamine), and its competitive bindi...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(03)00021-2
更新日期:2003-04-15 00:00:00