The role of alpha-2 adrenoceptors in the regulation of oxytocin neurones in the suckled rat.

abstract：:Bilateral inferior olive lesions, produced by systemic administration of the neurotoxin 3-acetylpyridine (3AP) produce a proconvulsant state specific for strychnine-induced seizures and myoclonus. We have proposed that these phenomena are mediated through increased excitation of cerebellar Purkinje cells, through acti...

journal_title：Brain research bulletin

authors： Anderson MC,Chung EY,Van Woert MH

更新日期：1990-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) constitutes a heterogeneous cerebral insult induced by traumatic biomechanical forces. Mitochondria play a critical role in brain bioenergetics, and TBI induces several consequences related with oxidative stress and excitotoxicity clearly demonstrated in different experimental model involv...

journal_title：Brain research bulletin

authors： Courtes AA,Gonçalves DF,Hartmann DD,da Rosa PC,Cassol G,Royes LFF,de Carvalho NR,Soares FAA

更新日期：2020-10-01 00:00:00

abstract：:The antidepressant desipramine has been shown to decrease synaptic membrane concentrations of the norepinephrine re-uptake transporter (NET) in vivo and in vitro, on both an acute and a chronic basis. The possible contribution of decreased NET synthesis to the chronic downregulation of the NETs has not been definitive...

journal_title：Brain research bulletin

authors： Zavosh A,Schaefer J,Ferrel A,Figlewicz DP

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:The effects of COX-2 inhibitors on seizure activity are controversial. The aim of the current study was to determine the post-treatment effect of aceclofenac on penicillin-induced experimental epilepsy. METHODS:Male Wistar rats were used in all experiments (n=18). The seizure activity was triggered by penicill...

journal_title：Brain research bulletin

authors： Taşkıran M,Taşdemir A,Ayyıldız N

更新日期：2017-04-01 00:00:00

abstract：:Transcription factor Pbx4 is recruited to form dimeric or trimeric complexes with Hox and/or Meis homeodomain proteins and participates in patterning the hindbrain and retina during vertebrate CNS development. We characterized a Pbx4 cDNA isolated from a Gekko japonicus brain and spinal cord cDNA library. Northern blo...

journal_title：Brain research bulletin

authors： Wang Y,Jiang X,Liu Y,Gu X,Huan Y,Ren L,Ding F,Gu X

更新日期：2009-12-16 00:00:00

abstract：:Gamma-secretase (GS) is an enzyme complex that cleaves numerous substrates, and it is best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ) peptides. Aberrant cleavage of APP can lead to Alzheimer's disease, so much research has been done to better understand GS structure and function in ho...

journal_title：Brain research bulletin

authors： Carroll CM,Li YM

更新日期：2016-09-01 00:00:00

abstract：:Massively obese males often show symptoms of hypogonadism, but the mechanism for this is unclear. Increased endogenous opioid inhibition of the hypothalamic GnRH pulse generator resulting in insufficient stimulation of the pituitary gonadotroph has been proposed as a possible mechanism. If this hypothesis is correct, ...

journal_title：Brain research bulletin

authors： Blank DM,Clark RV,Heymsfield SB,Rudman DR,Blank MS

更新日期：1994-01-01 00:00:00

abstract：:Some C57Bl/6 mice become obese, whereas others remain lean when raised on a high-fat diet. The mechanisms underlying this interindividual susceptibility to diet-induced obesity remain unknown. Because hypothalamus plays a major role in the regulation of body weight, this study was conducted to identify the differences...

journal_title：Brain research bulletin

authors： Xin X,Storlien LH,Huang XF

更新日期：2000-07-01 00:00:00

abstract：:Although the huge economic and social impact and the predicted incidence increase, neuroprotection for ischemic stroke remains as a therapeutically empty niche. In the present study, we investigated the rationale of the C-Phycocyanin (C-PC) treatment on global cerebral ischemia/reperfusion (I/R) injury in gerbils. We ...

journal_title：Brain research bulletin

authors： Pentón-Rol G,Marín-Prida J,Pardo-Andreu G,Martínez-Sánchez G,Acosta-Medina EF,Valdivia-Acosta A,Lagumersindez-Denis N,Rodríguez-Jiménez E,Llópiz-Arzuaga A,López-Saura PA,Guillén-Nieto G,Pentón-Arias E

更新日期：2011-08-10 00:00:00

abstract：:In the frog Rana esculenta the left dorsal habenula includes a lateral and a medial component, whereas the right dorsal habenula is only represented by one nucleus. The efferents of the habenular nuclei to the interpeduncular nucleus were herein investigated with the retrograde horseradish peroxidase tracing. Injectio...

journal_title：Brain research bulletin

authors： Gugliemotti V,Fiorino L

更新日期：1998-01-01 00:00:00

abstract：:Spinal NMDA receptors contribute to control of the cardiovascular system by the ventrolateral medulla. However, little is known about the contribution of these receptors to suprabulbar regulation of hemodynamics and sympathetic outflow. Hence, the involvement of spinal NMDA receptors in regulation of the cardiovascula...

journal_title：Brain research bulletin

authors： Porter JP

更新日期：1993-01-01 00:00:00

abstract：:One of the important factors altering the degree of blood-brain barrier (BBB) disruption in cerebral ischemia is the anesthetic used. The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway has been reported to be involved in modulating BBB permeability and in isoflurane induced neuroprotection. This study was perf...

journal_title：Brain research bulletin

authors： Chi OZ,Mellender SJ,Kiss GK,Liu X,Weiss HR

更新日期：2017-05-01 00:00:00

abstract：:A current response induced by superfusing adenosine was examined in substantia gelatinosa (SG) neurons of adult rat spinal cord slices by using the whole-cell patch-clamp technique. In 78% of the neurons examined, adenosine induced an outward current at -70 mV [18.8 +/- 1.1 pA (n = 98) at 1mM] in a dose-dependent mann...

journal_title：Brain research bulletin

authors： Liu T,Fujita T,Kawasaki Y,Kumamoto E

更新日期：2004-07-30 00:00:00

abstract：:The study was aimed at the investigation of the rat corticospinal system both functionally and anatomically using as a functional marker the immediate early gene c-fos, combined with retrograde tracing with horseradish peroxidase (HRP). This was achieved by mapping c-fos induction immunocytochemically in the spinal co...

journal_title：Brain research bulletin

authors： Wu YP,Ling EA

更新日期：1998-04-01 00:00:00

abstract：:The effects of delta-9-tetrahydrocannabinol (delta-9-THC) on monosynaptic population responses in hippocampal CA1 pyramidal cells were examined in acute rats for several doses and at several post injection time periods. Delta-9-THC enhanced paired pulse inhibition in a dose-dependent manner; however biphasic dose effe...

journal_title：Brain research bulletin

authors： Weisz DJ,Gunnell DL,Teyler TJ,Vardaris RM

更新日期：1982-02-01 00:00:00

abstract：:It has been demonstrated that the posteromedial cortical amygdaloid nucleus (PMCo), is sexually dimorphic. It is shown (Experiment 1) that male orchidectomy on the day of birth (D1) decreases the volume and number of neurons of the PMCo, while a single injection of propionate testosterone to the female on D1 masculini...

journal_title：Brain research bulletin

authors： Vinader-Caerols C,Collado P,Segovia S,Guillamón A

更新日期：2000-10-01 00:00:00

abstract：:The effect of subarachnoid hemorrhage (SAH) on the neuropeptides and mast cells of the rat dura mater has not been reported. We examined the outcome of SAH on the rat supratentorial dura mater to determine whether dural nerves undergo effects similar to those of nerves accompanying cerebral blood vessels after SAH. Fo...

journal_title：Brain research bulletin

authors： Keller JT,Mullen BG,Zuccarello M

更新日期：1993-01-01 00:00:00

abstract：:Mutations in PLA2G6, which encodes calcium-independent phospholipase A(2) group VIA (iPLA2-VIA), underlie the autosomal recessive disorder infantile neuroaxonal dystrophy (INAD). INAD typically presents in the first year of life, and leads to optic atrophy and psychomotor regression. We have examined PLA2G6 expression...

journal_title：Brain research bulletin

authors： Polster B,Crosier M,Lindsay S,Hayflick S

更新日期：2010-11-20 00:00:00

abstract：:Reserpine depletes dopamine (DA) levels and increases tyrosine hydroxylase (TH) activity in the rat corpus striatum. TH is activated not only by enhancement of DA neuronal impulse flow, but also by cessation of impulse flow. To assist in the understanding of the relative contribution of impulse flow to the regulation ...

journal_title：Brain research bulletin

authors： German DC,McMillen BA,Sanghera MK,Saffer SI,Shore PA

更新日期：1981-02-01 00:00:00

abstract：:The antinociceptive response of mice to the amino acid L-arginine (L-ARG) has been attributed to either an opioid mechanism or a non-opioid but nitric oxide (NO)-dependent mechanism. Earlier it was reported that the mechanism of nitrous oxide-induced antinociception involved opioid components and was also dependent on...

journal_title：Brain research bulletin

authors： Chung E,Burke B,Bieber AJ,Doss JC,Ohgami Y,Quock RM

更新日期：2006-07-31 00:00:00

abstract：:Isoflurane (ISO) is an anesthesia and can result in neuron injury. A previous study has indicated that microRNA-302b-3p (miR-302b-3p) exerts a crucial function in modulating cerebral ischemia/reperfusion damage-induced neuronal injury. We sought to examine the role of miR-302b-3p in ISO-induced neuronal injury. In the...

journal_title：Brain research bulletin

authors： Li L,Lu S,Fan X

更新日期：2020-12-25 00:00:00

abstract：:Specific angiotensin II (Ang II) binding sites are present in the dorsal medulla of several species, and dose-related cardiovascular effects are produced by microinjection of the peptide into this region. Because the anatomical location of Ang II binding sites in the area postrema (ap), nucleus tractus solitarii (nTS)...

journal_title：Brain research bulletin

authors： Diz DI,Barnes KL,Ferrario CM

更新日期：1986-10-01 00:00:00

abstract：:Effects of acute exposure (2 hr) to either 1.5% halothane or 0.5% methoxyflurane were investigated in the Sprague Dawley rat. Pituitary (PIT) and central nervous system (CNS) substance P (SP)-like and beta-endorphin (beta-end)-like immunoreactivities were evaluated immediately after anesthetic exposure (2 h), after ri...

journal_title：Brain research bulletin

authors： Karuri AR,Agarwal RK,Engelking LR,Kumar MS

更新日期：1998-03-15 00:00:00

abstract：:Spinal cord ischemia-reperfusion injury(SCII)affects nerve function through many mechanisms, which are complex and not fully understood. Recently, accumulating evidence has indicated that long noncoding RNAs (lncRNAs) play an increasingly important role in SCII. We investigated the role of lncRNA growth arrest-specifi...

journal_title：Brain research bulletin

authors： Zhang Z,Li X,Chen F,Li Z,Wang D,Ren X,Ma H

更新日期：2020-12-11 00:00:00

abstract：:The question of whether neurons versus fibers of passage in the medial prefrontal cortex (MPC) are essential in maintaining self-stimulation of this same area of the brain was examined. Rats were prepared with electrode-guide cannulae implanted stereotaxically to rest within MPC. A micro-injection of (KA), 10 nmol/1.0...

journal_title：Brain research bulletin

authors： Ferrer JM,Myers RD,Mora F

更新日期：1985-08-01 00:00:00

abstract：:Epigenetic processes are involved in regulation of cell functions and survival, but their role in responses of neurons and glial cells to oxidative injury is insufficiently explored. Here, we studied the role of DNA methylation and histone deacetylation in reactions of neurons and surrounding glial cells to photodynam...

journal_title：Brain research bulletin

authors： Sharifulina SA,Komandirov MA,Uzdensky AB

更新日期：2014-03-01 00:00:00

abstract：:In the present study, we showed for the first time the localization of ZNT7 immunoreactivity in the mouse dorsal root ganglion (DRG) by means of immunohistochemistry and confocal laser scanning microscopy. Our results revealed that ZNT7 immunoreactivity was abundantly expressed in the nerve cells of the mouse DRG. Str...

journal_title：Brain research bulletin

authors： Zhang L,Chi ZH,Ren H,Rong M,Dahlstrom A,Huang L,Wang ZY

更新日期：2007-09-28 00:00:00

abstract：:Progressive disruption of both the neuroendocrine and immune systems has been correlated with age-associated pathogenesis in patients with Alzheimer's disease and in mice lacking apolipoprotein E (ApoE). In this study, we examined neuroautoimmune and neuroendocrine activities in relation to aging and stress in ApoE-de...

journal_title：Brain research bulletin

authors： Zhou Y,Cheshire A,Howell LA,Ryan DH,Harris RB

更新日期：1999-06-01 00:00:00

abstract：:Repeated intraventricular injection of the excitatory amino acids glutamate and aspartate for one hour produced morphologic changes in the hippocampus that were qualitatively identical to the acute and chronic changes seen in the brains of human epileptics and in experimental animals in which hippocampal seizure activ...

journal_title：Brain research bulletin

authors： Sloviter RS,Dempster DW

更新日期：1985-07-01 00:00:00

abstract：:Orexin/hypocretin neurons of the lateral hypothalamus/perifornical area project to a diverse array of brain regions and are responsive to a variety of psychostimulant drugs. It has been shown that orexin neurons are activated by systemic nicotine administration suggesting a possible orexinergic contribution to the eff...

journal_title：Brain research bulletin

authors： Pasumarthi RK,Fadel J

更新日期：2008-12-16 00:00:00