Abstract：
:During a single-step visual tracking task of monkeys, parametric changes of the wrist extension-flexion movement and related discharge rate changes of pyramidal tract neurons (PTNs) of hand-arm motor area were studied. The task consisted of preparatory, precontraction, contraction and target periods. If the displacement amplitude was changed from narrow (10-20 degrees) to moderate (40 degrees) range, peak velocity, peak acceleration and contraction period increased linearly but precontraction period decreased slightly. In 61 movement-related PTNs, no linear relationships were found between PTN discharge rate during precontraction or contraction period and displacement amplitude, velocity, acceleration, precontraction period or contraction period. In less than 20% of PTNs, however, correlations between PTN discharge rate during precontraction period and velocity or acceleration were found in the moderate range task. It occurred less frequently in narrow range task. It is said in a visual tracking task that PTN activity is not dependent upon factors related to the task parameters, such as velocity, acceleration. Possible related factors were discussed.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Hamada I,Kubota Kdoi
10.1016/0361-9230(79)90289-2keywords:
subject
Has Abstractpub_date
1979-03-01 00:00:00pages
249-57issue
2eissn
0361-9230issn
1873-2747pii
0361-9230(79)90289-2journal_volume
4pub_type
杂志文章abstract：:We showed previously that the number and time of spike-wave discharges (SWDs) were increased after intraperitoneal (i.p.) injection of lipopolysaccharide (LPS), an effect, which was completely abolished by cyclooxygenase-2 (COX-2) inhibitor indomethacin (IND) pretreatment in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2014.03.003
更新日期：2014-05-01 00:00:00
abstract：:To elucidate the role of the medial basal hypothalamus (MBH) in stress-induced prolactin (Prl) release, adult male rats which had received monosodium glutamate (MSG 4 mg/g) on alternate days for the first 10 days of life were subjected to ether stress for 2 min. Blood samples were drawn at 0, 15, 30 and 60 min after e...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(83)90068-0
更新日期：1983-01-01 00:00:00
abstract：:Subcutaneous administration of the alpha 2-adrenoreceptor antagonists, yohimbine and tolazoline, at doses up to 1000 micrograms/kg, had no effect on water intake of female rats. However, when these compounds were administered SC in combination with either the beta-adrenoreceptor agonist, isoproterenol (10 to 25 microg...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(83)90083-7
更新日期：1983-01-01 00:00:00
abstract：:The effect of lithium chloride on the activity of the afferent nerve fibers from the abdominal organs was studied in anesthetized rats. The administration of the lithium chloride solution (0.15 M) over the mesentery increased afferent discharge rate of the splanchnic and vagal gastric nerve. Injection of the same solu...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90094-9
更新日期：1994-01-01 00:00:00
abstract：:Investigation of the differentiation of electrical properties of motoneurons has been stimulated by the importance of these neurons for embryonic behavior and facilitated by their experimental accessibility. In this review, we examine the development of different patterns of excitability and their functions, and discu...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/s0361-9230(00)00388-9
更新日期：2000-11-15 00:00:00
abstract：:Hippocampal theta activity is a large amplitude, sinusoidal wave that occurs during attentive immobility and exploratory behaviour in the rat, and it is thought to be involved in memory formation. Recent reports suggest that corticotropin-releasing hormone (CRH) has pro-mnemonic effects in rodents. Because memory-enha...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(99)00039-8
更新日期：1999-04-01 00:00:00
abstract：:The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of Parkinson's disease (PD). PD is triggered by genetic alterations, environmental/occupational exposures and aging. However, the exact molecular mechani...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2017.03.009
更新日期：2017-07-01 00:00:00
abstract：:The medial preoptic area is a key structure in the neural control of reproduction. Considerable evidence has accumulated indicating that glutamatergic innervation of the area plays an important role in this control. Sources of the glutamatergic input are unknown. Present investigations were aimed at studying this ques...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(03)00180-1
更新日期：2003-08-30 00:00:00
abstract：:A number of procedures exist for the experimental induction of sodium appetite. With the exception of a low sodium diet, nearly all of these methods are invasive, requiring injections, surgery, or both. In addition to stimulating intake of concentrated salt, some of them produce substantial side-effects like reduced f...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.03.009
更新日期：2004-07-30 00:00:00
abstract：:Polymerase chain reaction assays are a powerful tool for detecting the presence of infectious genomes in the cerebrospinal fluid. Positive results always mean a current or pending infection of the central nervous system. Subacute (>7 days) or chronic infections induce an intrathecal humoral immune response and the app...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(03)00093-5
更新日期：2003-08-15 00:00:00
abstract：OBJECTIVE:Parkinson's disease (PD) is a frequent degenerative disease of the nervous system with undefined pathogenesis. This study explored the protective effect of microRNA (miR)-218-5p on dopaminergic neuron injury in substantia nigra (SN) of rats with PD through the regulation of LIM and SH3 domain protein 1 (LASP1...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2020.10.019
更新日期：2021-01-01 00:00:00
abstract：:Cell-free incorporation of (14C) leucine into protein was 38% greater for cerebral cortical microsomes from 22-day old neonatally thyroidectomized rats compared to littermate controls. In contrast, incorporation by liver microsomes of hypothyroid rats was 33% lower compared to controls, confirming their deficient horm...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(80)90275-0
更新日期：1980-01-01 00:00:00
abstract：:Walker 256 carcinosarcoma cells produce subpleural pulmonary metastases when given intravenously to the Sprague-Dawley rat. The number of metastases increases when the rat is given morphine subsequent to the tumor load. The increase in the number of metastases can be blocked be pretreatment with the opiate antagonist ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(86)90057-2
更新日期：1986-03-01 00:00:00
abstract：:Central cholinergic neurons play an important role in learning and memory functions. The present study was undertaken to elucidate the pathological changes in learning function and acetylcholine metabolism of the cerebral cortex and hippocampus, following microsphere embolism in rats. Microspheres (48 microns) were in...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(96)00350-4
更新日期：1997-01-01 00:00:00
abstract：:Endogenous adrenergic drive regulates the firing rate of serotonergic neurons. However, advocates of feedback theory assert that 5-hydroxytryptamine (5-HT) released in the somatodendritic region of raphe neurons regulates both rate and release of 5-HT. Experiments were done to determine if the somatodendritic region m...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(01)00567-6
更新日期：2001-08-01 00:00:00
abstract：:In the central nervous system cell migration is usually restricted to developmental periods and occurs mainly radially, following the radial glia. Nevertheless, in the subependymal layer of the adult rodent forebrain tangential migration of newly generated neuronal precursors directed to the olfactory bulb, which foll...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(96)00116-5
更新日期：1997-01-01 00:00:00
abstract：:The anticonvulsant drug Diazepam (DIA-2 mg/kg b. wt), the nitric oxide (NO) donor L-Arginine (L-Arg-2000 mg/kg b. wt) and the putative nitric oxide synthase (NOS) inhibitor N(G)-Nitro-L-Arginine methyl ester (L-NAME-50 mg/kg b. wt) were used to determine the role of endogenous NO on convulsions induced by picrotoxin (...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(99)00011-8
更新日期：1999-03-01 00:00:00
abstract：:The role of several hippocampal innervations in the sensitivity to barbital-induced narcosis was studied in selected mice strains. The outbred and inbred mouse strains HS/lgb, SABRA/HUC, C57BL, CBA/LAC, and BALB/c were tested for barbital-induced sleep (315 mg/kg). The relatively short sleeping HS/lbg (HS) and the lon...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(95)00077-r
更新日期：1995-01-01 00:00:00
abstract：:Aluminium is highly neurotoxic and inhibits prenatal and postnatal development of the brain in humans and experimental animals. However, the incorporation of aluminium into the brain of fetuses and sucklings during gestation and lactation has not been well clarified because aluminium lacks a suitable isotope for a tra...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(01)00509-3
更新日期：2001-05-15 00:00:00
abstract：:A substantial and still growing body of research tries to link different psychological models and chronic diseases, with special emphasis on cardiovascular disease. These efforts have established several conceptual bridges that connect psychological alterations and psychosocial factors to the risks, onset and prognosi...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2003.12.001
更新日期：2004-02-01 00:00:00
abstract：:The effects of intracerebroventricular (ICV) colchicine (70 micrograms per rat) on systolic pressures and levels of hexokinase activity in the hypothalamic paraventricular (PVH) and supraoptic (SON) nuclei were investigated in adult normotensive and spontaneously hypertensive rats (SHR). One day after colchicine injec...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(89)90162-7
更新日期：1989-07-01 00:00:00
abstract：:Under standard laboratory conditions rats given access to three separate macronutrient sources compose a diet yielding 31% of their total daily calories as protein, 34% as carbohydrate, and 34% as fat. This selection pattern is dramatically altered with restored access following a 48 h fast. During the first hour of r...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(93)90305-u
更新日期：1993-01-01 00:00:00
abstract：:Many objective and quantitative methods have been developed to create a procedure or a device to prove, describe and quantify olfactory deficit and anosmia, especially after a head trauma. Electrophysiological testing throughout olfactoelectroencephalography (olfactoEEG) is based on brain activity desynchronisation, a...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2006.08.004
更新日期：2006-12-11 00:00:00
abstract：:Interleukin-1beta (IL-1beta), a cytokine with pronounced central effects such as fever, anorexia, analgesia, etc., is also known to activate the hypothalamo-pituitary-adrenal (HPA) axis. Corticotropin releasing hormone (CRH) neurons located in the hypothalamus are important for HPA activation. The cell bodies of CRH n...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2005.02.021
更新日期：2005-05-15 00:00:00
abstract：:Concomitant behavioral and dorsal raphe (DR) neuronal activity were recorded following acute and chronic dose response of methylphenidate (MPD) in freely moving rats previously implanted with permanent semi-microelectrodes using telemetric (wireless) technology. On experimental day (ED) 1, the neuronal and locomotor a...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2013.06.004
更新日期：2013-09-01 00:00:00
abstract：:Neonatal post-hemorrhagic hydrocephalus is associated with cognitive decline and a serious deterioration in the patient's quality of life. The underlying impairments to neurons are not well understood. Here, we used the method described by Cherian et al. to construct a model of hydrocephalus after intra-ventricular he...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2010.06.009
更新日期：2010-08-30 00:00:00
abstract：:Fourteen patients with high- (n = 7) and low-dose (n = 7) benzodiazepine (BDZ) dependency presented predominantly with anxious and depressive neurotic symptoms which caused long-term BDZ medication. Their BDZ dependency was characterized by giving preference to the abuse of benzodiazepines with long elimination half-l...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(87)90109-2
更新日期：1987-09-01 00:00:00
abstract：:Neurodevelopmental disorders such as autism and schizophrenia involve social interaction problems and poor mentalizing abilities, associated with abnormal regional cerebral activity. Similar problems may be present in aggressive personality disorders and psychopathy. This paper reviews brain imaging data from research...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2006.01.008
更新日期：2006-04-14 00:00:00
abstract：:Chronic stress, a risk factor for the development of psychiatric disorders, is known to induce alterations in neuronal networks in many brain areas. Previous studies have shown that chronic stress changes the expression of the cannabinoid receptor 1 (CB1) in the brains of adult rats, but neurophysiological consequence...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2011.04.005
更新日期：2011-07-15 00:00:00
abstract：:Electrical stimulation has been shown to have neuroprotective effects on ganglion cells and photoreceptors in axotomized and dystrophic retinas from Royal College of Surgeons (RCS) rats. This study determined whether electrical stimulation also has a neuroprotective effect on cells in the inner nuclear layer (INL) of ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.12.013
更新日期：2009-04-06 00:00:00
