Morphine increases metastatic tumor growth.

abstract：:Our previous results showed that neurochemical destruction of the amygdaloid terminal field of the mesolimbic dopaminergic system caused disturbances in body weight regulation and feeding. In the present experiments, it was studied whether 6-hydroxydopamine (6-OHDA)-induced bilateral lesions of the mesolimbic dopamine...

journal_title：Brain research bulletin

authors： Lénárd L,Karádi Z,Jandó G,Yoshimatsu H,Hajnal A,Sándor P,Oomura Y

更新日期：1991-09-01 00:00:00

abstract：:Depression and anxiety have been reported as the major neuropsychiatric consequences following stroke. Minocycline, a neuroprotective drug has minimized depressive symptoms in patients with major depressive disorders and anxiety-like symptoms. In addition, minocycline demonstrated efficacy and seemed a promising neuro...

journal_title：Brain research bulletin

authors： Camargos QM,Silva BC,Silva DG,Toscano ECB,Oliveira BDS,Bellozi PMQ,Jardim BLO,Vieira ÉLM,de Oliveira ACP,Sousa LP,Teixeira AL,de Miranda AS,Rachid MA

更新日期：2020-02-01 00:00:00

abstract：:The distribution of tissue plasminogen activator (tPA) messenger RNA in rat brain was studied using in situ hybridization with 35S UTP-labeled RNA probes derived from a full-length tPA cDNA. Sense strand controls produced low, even backgrounds, with small elevations in the hippocampus. Full-length antisense probes pro...

journal_title：Brain research bulletin

authors： Ware JH,Dibenedetto AJ,Pittman RN

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Parkinson's disease (PD) is a frequent degenerative disease of the nervous system with undefined pathogenesis. This study explored the protective effect of microRNA (miR)-218-5p on dopaminergic neuron injury in substantia nigra (SN) of rats with PD through the regulation of LIM and SH3 domain protein 1 (LASP1...

journal_title：Brain research bulletin

authors： Ma X,Zhang H,Yin H,Geng S,Liu Y,Liu C,Zhao J,Liu Y,Wang X,Wang Y

更新日期：2021-01-01 00:00:00

abstract：:Many similarities exist between the inhibitory influence of estrogen on food intake (FI) and body weight (BWt) in female rats and the effect of lateral hypothalamic (LH) lesions on energy balance. Thus, a possible interaction of small electrolytic LH lesions (0.8 mA/10 sec) with hormone-dependent changes in FI, BWt an...

journal_title：Brain research bulletin

authors： Nance DM,Gorski RA

更新日期：1978-09-01 00:00:00

abstract：:The vertebrate neural tube consists of a series of neuromeres along its anteroposterior axis. Between amphioxus that possesses no neuromeres and gnathostomes, the lamprey occupies a critical position in the phylogeny for the origin of the segmented brain. To clarify the rhombomeric configuration of the Japanese lampre...

journal_title：Brain research bulletin

authors： Murakami Y,Ogasawara M,Satoh N,Sugahara F,Myojin M,Hirano S,Kuratani S

更新日期：2002-02-01 00:00:00

abstract：:Using the in vitro hamster hypothalamic slice preparation, the effects of GABA and 80% chloride (Cl-) reduced medium on the single unit activity of SCN neurons was investigated. GABA 10(-4) M produced inhibitory responses in 55% of the 69 SCN neurons examined. No statistically significant day-night difference was obse...

journal_title：Brain research bulletin

authors： Liou SY,Albers HE

更新日期：1990-07-01 00:00:00

abstract：:In the present study, cellular tropism and relative transduction efficiency of AAV2/6, AAV2/8 and AAV2/9 vectors have been tested for the cornea using primary cultures of human corneal fibroblasts. The AAV6, AAV8 and AAV9 serotypes having AAV2 ITR plasmid encoding for alkaline phosphatase (AP) gene were generated by t...

journal_title：Brain research bulletin

authors： Sharma A,Ghosh A,Hansen ET,Newman JM,Mohan RR

更新日期：2010-02-15 00:00:00

abstract：:Studies were conducted to determine if norepinephrine activates both protein kinase C and the cyclic AMP-dependent protein kinase in cultured rat astrocytes using phosphoproteins as markers. Norepinephrine was found to decrease 32P incorporation into an acidic 80,000 M(R) protein. A similar response was observed with ...

journal_title：Brain research bulletin

authors： Mobley PL,Combs DL

更新日期：1992-09-01 00:00:00

abstract：:Excised lateral eye retinular cells of Limulus polyphemus exposed to chlorobutanol were examined using microelectrode techniques. The effects observed were: (1) a marked shortening of the receptor potential latent period; (2) a decrease in the effective input resistance of retinular cells to hyperpolariziog currents; ...

journal_title：Brain research bulletin

authors： Wulff VJ,Jahy JL

更新日期：1977-05-01 00:00:00

abstract：:The present study was conducted to examine the effects of d-amphetamine and the designer drugs 3,4-methylenedioxymethamphetamine (MDMA), N-methyl-3,4-methylenedioxyphenyl-3-butamine (HMDMA), 3,4-methylenedioxyphenyl-2-butanamine (BDB), 3,4-methylenedioxyphenyl-1-ethanamine (MDM1EA) in the chick embryo and the young ch...

journal_title：Brain research bulletin

authors： Bronson ME,Jiang W,Clark CR,DeRuiter J

更新日期：1994-01-01 00:00:00

abstract：:A significant pathological feature of refractory temporal lobe epilepsy (TLE) is neuronal loss. Oxidative stress caused by repeated seizures is an important mechanism leading to neuronal loss in hippocampus. Nicotinamide-adenine dinucleotide (NAD) a coenzyme that is involved in many biochemical oxidation-reduction rea...

journal_title：Brain research bulletin

authors： Wu H,Meng Q,Zhang Y,Li H,Liu Y,Dong S,Liu B,Zhang H

更新日期：2021-02-01 00:00:00

abstract：:Several works have shown that males and females differ in the ability to learn spatial locations in mazes. In this study, we used the Morris water maze to assess the acquisition of a spatial working memory (WM) task in adult male and female Wistar rats. The task consisted of a paired sample procedure made up of two da...

journal_title：Brain research bulletin

authors： Méndez-López M,Méndez M,López L,Arias JL

更新日期：2009-05-29 00:00:00

abstract：:Previous cytoarchitectural and electron micrographic studies have indicated that the gustatory zone of the nucleus of the solitary tract (NST) may contain local circuit neurons. It is known that neurons of the caudal "visceroceptive" NST contain GABA, glutamic acid decarboxylase (EC 4.1.1.15), and GABA-transaminase (G...

journal_title：Brain research bulletin

authors： Lasiter PS,Kachele DL

更新日期：1988-10-01 00:00:00

abstract：:Degeneration of substantia nigra dopaminergic neurons is a key pathological change of Parkinson's disease (PD), and its motor consequences have been widely recognized. Recently, mood disorders associated with PD have begun to attract a great deal of interest, however, their pathogenesis remains unclear. PD is associat...

journal_title：Brain research bulletin

authors： Luo XF,Zhang BL,Li JC,Yang YY,Sun YF,Zhao H

更新日期：2015-01-01 00:00:00

abstract：:Trans-2, 4-dimethoxystibene (S3) is a synthetic stilbenes. In the present study, S3 was investigated to assess its neuroprotective effect against the toxicity induced by Abeta(25-35) in hypercholesterolemic rats. Rats were fed with hypercholesterolemic chow for six weeks, and then received a single intracerebroventric...

journal_title：Brain research bulletin

authors： Ruan CJ,Li Z,Zhang L,Chen DH,Du GH,Sun L

更新日期：2010-07-30 00:00:00

abstract：:The role of calmodulin (CaM) in organelle motility (fast axonal transport) in the axoplasm of the squid giant axon was evaluated directly using video-enhanced microscopy. Addition of 6 microM CaM to extruded squid axoplasm produced a 2.6-fold increase in the number of organelles moving per minute per unit area of axop...

journal_title：Brain research bulletin

authors： Rivera DT,Langford GM,Weiss DG,Nelson DJ

更新日期：1995-01-01 00:00:00

abstract：:A number of procedures exist for the experimental induction of sodium appetite. With the exception of a low sodium diet, nearly all of these methods are invasive, requiring injections, surgery, or both. In addition to stimulating intake of concentrated salt, some of them produce substantial side-effects like reduced f...

journal_title：Brain research bulletin

authors： Caloiero VG,Lundy RF

更新日期：2004-07-30 00:00:00

abstract：:Hippocampal theta activity is a large amplitude, sinusoidal wave that occurs during attentive immobility and exploratory behaviour in the rat, and it is thought to be involved in memory formation. Recent reports suggest that corticotropin-releasing hormone (CRH) has pro-mnemonic effects in rodents. Because memory-enha...

journal_title：Brain research bulletin

authors： Kortekaas R,Costall B,Smythe JW

更新日期：1999-04-01 00:00:00

abstract：:A growing body of evidence has pointed to the NMDA receptor antagonists as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural and molecular effects of the acute and chronic treatment with memantine and imipramine in rats. To this aim, rats were acu...

journal_title：Brain research bulletin

authors： Réus GZ,Stringari RB,Kirsch TR,Fries GR,Kapczinski F,Roesler R,Quevedo J

更新日期：2010-04-05 00:00:00

abstract：:The effect of subarachnoid hemorrhage (SAH) on the neuropeptides and mast cells of the rat dura mater has not been reported. We examined the outcome of SAH on the rat supratentorial dura mater to determine whether dural nerves undergo effects similar to those of nerves accompanying cerebral blood vessels after SAH. Fo...

journal_title：Brain research bulletin

authors： Keller JT,Mullen BG,Zuccarello M

更新日期：1993-01-01 00:00:00

abstract：:Several studies have demonstrated that a descending dopaminergic pathway innervates the dorsal and the intermediate gray matter of the spinal cord and have suggested that this pathway is involved in pain modulation and in the control of autonomic functions. Other studies have also demonstrated the presence of dopamine...

journal_title：Brain research bulletin

authors： Weil-Fugazza J,Godefroy F

更新日期：1993-01-01 00:00:00

abstract：:One of the important factors altering the degree of blood-brain barrier (BBB) disruption in cerebral ischemia is the anesthetic used. The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway has been reported to be involved in modulating BBB permeability and in isoflurane induced neuroprotection. This study was perf...

journal_title：Brain research bulletin

authors： Chi OZ,Mellender SJ,Kiss GK,Liu X,Weiss HR

更新日期：2017-05-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the mature brain. At an early developmental period, it acts in an excitatory manner that influences many processes of proliferation, migration, and differentiation of the neurons. Previous evidence indicated that manipulation of the GABAergi...

journal_title：Brain research bulletin

authors： Naderipoor P,Amani M,Abedi A,Sakhaie N,Sadegzadeh F,Saadati H

更新日期：2021-01-10 00:00:00

abstract：:We previously reported that systemic treatment with a noncompetitive antagonist affecting the NMDA subtype of excitatory amino acid (EAA) receptor, MK-801, inhibits photic induction of Fos-like immunoreactivity (Fos-lir) in the hamster suprachiasmatic nucleus (SCN). Because MK-801 blocks the Ca2+ channel associated wi...

journal_title：Brain research bulletin

authors： Abe H,Rusak B,Robertson HA

更新日期：1992-05-01 00:00:00

abstract：:Wnt/β-catenin signaling plays an essential role in blood-brain barrier (BBB) formation and maintenance under pathophysiological conditions. HLY78, a lycorine derivative, has been identified as a novel activator of Wnt/β-catenin signaling in vitro. However, the effects of HLY78 on the BBB function in subarachnoid hemor...

journal_title：Brain research bulletin

authors： Luo X,Li L,Zheng W,Gu L,Zhang X,Li Y,Xie Z,Cheng Y

更新日期：2020-09-01 00:00:00

abstract：:Various reports have suggested that penehyclidine hydrochloride (PHC), a new cholinergic antagonist, exhibits a variety of biological actions such as anti-tumor and cardioprotective effects. This study aimed to investigate the effects of PHC on cerebral ischemia/reperfusion (I/R) injury and evaluate whether the c-Jun ...

journal_title：Brain research bulletin

authors： Shu Y,Yang Y,Zhang P

更新日期：2016-03-01 00:00:00

abstract：:Early developmental abnormalities affecting mesocortical dopamine (DA) neurons may result in later functional deficits that play a role in the emergence of psychiatric illness in adolescence/early adulthood. Little is known about the functional maturation of these neurons under either normal or abnormal conditions. In...

journal_title：Brain research bulletin

authors： Boyce PJ,Finlay JM

更新日期：2009-04-29 00:00:00

abstract：:Locomotor activity was increased as a function of current intensity in a series of rats with chronic stimulating electrodes in the tegmental pedunculopontine nucleus. Single pulse stimulation of these same mesencephalic locomotor region (MLR) sites antidromically activated more than one-quarter of the neurons sampled ...

journal_title：Brain research bulletin

authors： Mogenson GJ,Wu M

更新日期：1986-03-01 00:00:00

abstract：:Cultures of endothelial cells (EC) derived from human (autopsy) and canine brain microvessels were characterized with respect to growth, morphology, and biochemical features. The endothelial nature of these cells was confirmed by analyses of angiotensin-converting enzyme activity, Factor VIII-related antigen, and ultr...

journal_title：Brain research bulletin

authors： Gerhart DZ,Broderius MA,Drewes LR

更新日期：1988-11-01 00:00:00