Omega-conotoxin GVIA potently inhibits the currents mediated by P2X receptors in rat DRG neurons.

abstract：:Scientific reports suggest that the exposure to long-term stressors throughout or during late gestation increase anxiety- and depression-like behaviors of offspring in their later life. Moreover, several studies concluded that increasing age correlates with increased anxiety behaviors in humans and rodents. In the pre...

journal_title：Brain research bulletin

authors： Enayati M,Solati J,Hosseini MH,Shahi HR,Saki G,Salari AA

更新日期：2012-02-10 00:00:00

abstract：:Administering increasing dosages of 5alpha-dihydrotestosterone propionate (DHTP) (0, 40, or 80 microgram/100 g in oil daily) to ovariectomized female rats treated concurrently with estradiol benzoate (EB) (1 microgram/100 g in oil daily) caused significant, equivalent reduction in lordotic responsiveness in rats maint...

journal_title：Brain research bulletin

authors： Menniti FS,Erskine MS,Baum MJ

更新日期：1981-07-01 00:00:00

abstract：:The anticonvulsant drug Diazepam (DIA-2 mg/kg b. wt), the nitric oxide (NO) donor L-Arginine (L-Arg-2000 mg/kg b. wt) and the putative nitric oxide synthase (NOS) inhibitor N(G)-Nitro-L-Arginine methyl ester (L-NAME-50 mg/kg b. wt) were used to determine the role of endogenous NO on convulsions induced by picrotoxin (...

journal_title：Brain research bulletin

authors： Jayakumar AR,Sujatha R,Paul V,Puviarasan K,Jayakumar R

更新日期：1999-03-01 00:00:00

abstract：:Catecholaminergic systems, specifically in the region of the lateral perifornical hypothalamus (PFH), have been linked to the inhibition of feeding behavior. The present studies examined the effects of d-amphetamine (AMPH), which is believed to act through the release of endogenous catecholamines (CAs), on spontaneous...

journal_title：Brain research bulletin

authors： Leibowitz SF,Shor-Posner G,Maclow C,Grinker JA

更新日期：1986-11-01 00:00:00

abstract：:A significant pathological feature of refractory temporal lobe epilepsy (TLE) is neuronal loss. Oxidative stress caused by repeated seizures is an important mechanism leading to neuronal loss in hippocampus. Nicotinamide-adenine dinucleotide (NAD) a coenzyme that is involved in many biochemical oxidation-reduction rea...

journal_title：Brain research bulletin

authors： Wu H,Meng Q,Zhang Y,Li H,Liu Y,Dong S,Liu B,Zhang H

更新日期：2021-02-01 00:00:00

abstract：:The study was aimed at the investigation of the rat corticospinal system both functionally and anatomically using as a functional marker the immediate early gene c-fos, combined with retrograde tracing with horseradish peroxidase (HRP). This was achieved by mapping c-fos induction immunocytochemically in the spinal co...

journal_title：Brain research bulletin

authors： Wu YP,Ling EA

更新日期：1998-04-01 00:00:00

abstract：:Degeneration of substantia nigra dopaminergic neurons is a key pathological change of Parkinson's disease (PD), and its motor consequences have been widely recognized. Recently, mood disorders associated with PD have begun to attract a great deal of interest, however, their pathogenesis remains unclear. PD is associat...

journal_title：Brain research bulletin

authors： Luo XF,Zhang BL,Li JC,Yang YY,Sun YF,Zhao H

更新日期：2015-01-01 00:00:00

abstract：:The non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) attenuates morphine-induced immediate-early gene expression in the rat striatum in a sexually dimorphic manner that depends in part on gonadal steroids. To determine if this effect was dependent on modulation of glutamate receptor...

journal_title：Brain research bulletin

authors： D'Souza DN,Harlan RE,Garcia MM

更新日期：2003-01-15 00:00:00

abstract：:Previous studies using a pharmacological approach suggested a neural pathway emanating from the periaqueductal gray (PAG) to the nucleus accumbens relevant to antinociception. This was investigated with neurochemical and histochemical methods in the present study. Push-pull perfusion and radioimmunoassay were used to ...

journal_title：Brain research bulletin

authors： Ma QP,Han JS

更新日期：1992-06-01 00:00:00

abstract：:Serotonin 5-HT1A receptors belong to the superfamily of G-protein-coupled receptors. Receptor activation of G-proteins can be determined by agonist-stimulated [35S]GTPgammaS binding in the presence of excess GDP, and in vitro autoradiographic adaptation of this technique allows visualization of receptor-activated G-pr...

journal_title：Brain research bulletin

authors： Sim LJ,Xiao R,Childers SR

更新日期：1997-01-01 00:00:00

abstract：:A combined hardware/software system for the study of the temporal distributions of spike data is described. Through extensive use of assembly language subroutines the program is able to simultaneously acquire, analyze and display the incoming data. Production of a "Temporal Memory Map" makes possible the examination o...

journal_title：Brain research bulletin

authors： Cohen MS,Pfaff DW

更新日期：1984-07-01 00:00:00

abstract：:To investigate the direct actions of neurotropin (NSP, a nonproteinaceous extract from inflamed skin of rabbits which is in therapeutic use), intracellular recordings were made from neurons of the ventromedial hypothalamic nucleus (VMH) and lateral hypothalamic area (LHA) in slices of guinea pig brain. In the VMH, NSP...

journal_title：Brain research bulletin

authors： Shimizu N,Duan S,Hori T,Oomura Y

更新日期：1992-12-01 00:00:00

abstract：:Acute inflammation activates macrophages or monocytes and subsequently releases several inflammatory cytokines and reactive oxygen and nitrogen species. These proinflammatory cytokines activate astrocytes and trigger neurodegenerative diseases. In this work, we chose to address the mechanistic aspects of alpha-crystal...

journal_title：Brain research bulletin

authors： Masilamoni JG,Vignesh S,Kirubagaran R,Jesudason EP,Jayakumar R

更新日期：2005-10-15 00:00:00

abstract：:The influence of gender and stage of the estrous cycle on the levels of acetylcholine, serotonin, and noradrenaline in the hippocampus and on the susceptibility of the cholinergic septo-hippocampal pathway to the neurotoxic effect of ethylcholine aziridinium (AF64A) was investigated in the rat. Levels of acetylcholine...

journal_title：Brain research bulletin

authors： Hörtnagl H,Hansen L,Kindel G,Schneider B,el Tamer A,Hanin I

更新日期：1993-01-01 00:00:00

abstract：:Degenerating terminals were mapped by the Fink-Heimer method after lateral or fourth ventricular administration of 6-hydroxydopamine (60OHDA). This method marks dopaminergic terminals and has the advantage that noradrenergic terminals are not stained. Fink-Heimer stained degeneratig terminals were seen bilaterally in ...

journal_title：Brain research bulletin

authors： Hedreen J

更新日期：1980-07-01 00:00:00

abstract：:Aβ plaques of Alzheimer's disease (AD) are believed to precede cognitive deficits or clinical manifestation by decades. However, validated biomarkers for early diagnosis of the AD disease are still not available. In this present study, we combined MRI-based neuroimages and histological assessment of the glial response...

journal_title：Brain research bulletin

authors： Liu L,Liu Y,Li N,Huang R,Zheng X,Huang L,Hou S,Yuan Q

更新日期：2020-03-01 00:00:00

abstract：:High dietary salt intake activates the brain renin-angiotensin system in spontaneously hypertensive rats (SHR) and Dahl S rats, resulting in sympathetic hyperactivity and hypertension. Increases of sodium concentration in cerebrospinal fluid (CSF) and/or enhanced responses to CSF sodium are considered to be involved i...

journal_title：Brain research bulletin

authors： Kubo T,Hagiwara Y

更新日期：2006-01-30 00:00:00

abstract：:The expression of ErbB4 mRNA was examined in dorsal thalamic regions of chicks and rats. In rats, ErbB4 expression was observed in the habenular nuclei, the paraventricular nucleus, intermediodorsal nucleus, the central medial thalamic nucleus, the posterior nucleus, the parafascicular nucleus, the subparafascicular n...

journal_title：Brain research bulletin

authors： Bruce LL,Kornblum HI,Seroogy KB

更新日期：2002-02-01 00:00:00

abstract：:Progesterone receptor (PR) isoforms expression was determined in several regions of the prepuberal and adult male rat brain by using reverse transcription coupled to polymerase chain reaction. Rats under a 14:10-h light-dark cycle, with lights on at 0600 h were used. We found that in the hypothalamus of prepuberal ani...

journal_title：Brain research bulletin

authors： Guerra-Araiza C,Reyna-Neyra A,Salazar AM,Cerbón MA,Morimoto S,Camacho-Arroyo I

更新日期：2001-01-01 00:00:00

abstract：:To acquire knowledge about the environment two types of learning are necessary: declarative localizatory learning about where environmental cues and the subject are, and procedural learning about how to explore and move around the environment. Experimental data indicate that hippocampal regions are involved in spatial...

journal_title：Brain research bulletin

authors： Leggio MG,Federico F,Neri P,Graziano A,Mandolesi L,Petrosini L

更新日期：2006-10-16 00:00:00

abstract：:The effect of pretreatment of geranylgeranylacetone (GGA), an inducer of heat shock protein (HSP) 70, on responses in sleep and core body temperature (Tcore) against sleep deprivation (SD) was examined in rats. After 3 days of GGA or vehicle injection, a 6-h period of SD was performed. During the recovery period, both...

journal_title：Brain research bulletin

authors： Wada T,Sei H,Kusumoto K,Kitaoka K,Chikahisa S,Rokutan K,Morita Y

更新日期：2006-04-28 00:00:00

abstract：:Sporadic Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder affected by amyloid and vascular pathogenesis. Brain insulin resistance (BIR) has been suggested as one of the pathomechanisms of sporadic AD. We investigated how the amyloid and vascular pathogenesis of AD interacts with BIR. We examined...

journal_title：Brain research bulletin

authors： Choi BR,Seo JH,Back DB,Han JS,Choi DH,Kwon KJ,Shin CY,Lee J,Kim HY

更新日期：2020-05-01 00:00:00

abstract：:The mechanism of action of the anticonvulsant drug valproic acid (VPA) was studied in rat amygdaloid slices using intracellular recording techniques. In the presence of bicuculline (20 microM), stimulation of the endopyriform nucleus evoked an excitatory postsynaptic potential (EPSP) followed by a paroxysmal depolariz...

journal_title：Brain research bulletin

authors： Gean PW,Huang CC,Hung CR,Tsai JJ

更新日期：1994-01-01 00:00:00

abstract：:Several hypotheses have been proposed to explain why some neurological patients fail to recognise objects from unusual views: that it results from difficulty identifying an object's principal axis when it is foreshortened, identifying an object when landmark features are occluded, or an inability to rotate mental imag...

journal_title：Brain research bulletin

authors： Turnbull OH,McCarthy RA

更新日期：1996-01-01 00:00:00

abstract：:Somatostatin immunoreactive (SOM-I) perikarya were first observed in the ventral horn at E12, in the presumptive intermediate gray area at E14, and in the alar plate of the rostral spinal cord at E14. In general, after their initial appearance, their density increased and then decreased during development. A moderate ...

journal_title：Brain research bulletin

authors： Ho RH

更新日期：1988-07-01 00:00:00

abstract：:Rats with chronic hippocampal electrode implants had afterdischarges induced with electrical stimulus intensities of 115, 200, and 800% of a previously determined threshold. Afterdischarge duration, postictal EEG depression duration, and the duration of postictal electrical hypoexcitability were assessed. After discha...

journal_title：Brain research bulletin

authors： Swartzwelder HS,Wegener ST,Johnson CT,Dyer RS

更新日期：1980-09-01 00:00:00

abstract：:The interaction between nitric oxide (NO) and the release of [(3)H]noradrenaline ([(3)H]NA) in conditions of non-activated and activated nicotinic receptors in guinea-pig gastric fundus preincubated with [(3)H]NA was studied. Nicotinic receptor agonist, 1,1-dimethyl-4-phenyl-piperazinium iodide (DMPP) (100 microM) sig...

journal_title：Brain research bulletin

authors： Sotirov E,Papasova M

更新日期：2000-03-15 00:00:00

abstract：:Impairment of endosomal/lysosomal functions are reported as some of the earliest changes in several age-related neurological disorders such as Alzheimer's disease. Dysregulation of the lysosomal system is also accompanied by the accumulation of age-associated pigments and several recent reports have indicated that thi...

journal_title：Brain research bulletin

authors： Ditaranto-Desimone K,Saito M,Tekirian TL,Saito M,Berg M,Dubowchik G,Soreghan B,Thomas S,Marks N,Yang AJ

更新日期：2003-02-15 00:00:00

abstract：:The possible existence of two separate RSA generators in the dorsal hippocampus raises questions as to the degree of coupling or independence of both. In order to answer these questions bipolar EEG recording were made in the CA1 and dentate gyrus of freely moving rats during conditions of RSA generation by different m...

journal_title：Brain research bulletin

authors： Krug M,Brödemann R,Ott T

更新日期：1981-01-01 00:00:00

abstract：:The role of several hippocampal innervations in the sensitivity to barbital-induced narcosis was studied in selected mice strains. The outbred and inbred mouse strains HS/lgb, SABRA/HUC, C57BL, CBA/LAC, and BALB/c were tested for barbital-induced sleep (315 mg/kg). The relatively short sleeping HS/lbg (HS) and the lon...

journal_title：Brain research bulletin

authors： Yanai J,Pick CG

更新日期：1995-01-01 00:00:00