Abstract：
:After placing bilateral electrolytic lesions in the fasciculus retroflexus (FR) of the rat, the endogenous content of serotonin, glutamate and gamma-aminobutyrate (GABA) as well as choline acetyltransferase activity (ChAT) were measured in the interpeduncular nucleus (IPN) at the 7th, 28th and 120th survival days. Confirming earlier results, an almost total depletion of ChAT was obtained in the IPN following complete FR lesions at any survival day studied. In such cases, the following changes were observed; 1) the serotonin level increased consistently and roughly doubled at the 120th survival day, suggesting heterotypic sprouting of serotonergic fibers and/or enhanced serotonin synthesis in the serotonergic neurons in the IPN, 2) the glutamate level decreased by approximately one-half, while the activity of high affinity uptake of glutamate remained unaltered, at the 7th survival day, suggesting a lowered glutamate formation coupled with lowered glucose utilization in the IPN, and 3) the GABA level decreased at a slower rate and reached one-third of the control at the 120th survival day, for which either transsynaptic degeneration of GABA neurons in the IPN or a suppressed metabolic rate in the GABA shunt following the lowered glutamate formation is a possible explanation.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Takishita N,Kubo H,Mitani A,Nakamura Y,Masuda S,Iwahashi K,Kataoka Kdoi
10.1016/0361-9230(90)90113-esubject
Has Abstractpub_date
1990-10-01 00:00:00pages
569-74issue
4eissn
0361-9230issn
1873-2747pii
0361-9230(90)90113-Ejournal_volume
25pub_type
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更新日期：2008-07-01 00:00:00
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更新日期：1996-01-01 00:00:00
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更新日期：1992-09-01 00:00:00
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更新日期：1996-01-01 00:00:00
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更新日期：1991-12-01 00:00:00
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更新日期：1999-09-01 00:00:00
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更新日期：1992-02-01 00:00:00
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journal_title：Brain research bulletin
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更新日期：1979-09-01 00:00:00
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更新日期：1987-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2000-11-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1985-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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更新日期：2017-01-01 00:00:00
