Inhibitory pathway from the frontal cortex to the hypothalamic ventromedial nucleus in the rat.

Abstract:

:Stimulation of the dorsal frontal cortex (area 10, FCtx) evoked two negative waves with short latencies (N1 and N2) followed by a large, longlasting positive wave (P) in the ventromedial nucleus (VMH) as well as in the more dorsal structures in the hypothalamus and the ventral thalamus. Since the N1 followed high frequency stimulation, it was concluded to be due to antidromic activity. Double or triple pulse stimulation summated the P, and reduced the amplitude of the negative waves of the second and the third responses. VMH neuronal discharges were also decreased during the time course of the P. Therefore, the P was concluded to be composed of the IPSPs. VMH neuronal discharges were frequently superimposed on the N2, indicating the origin of this wave to be EPSPs. Strychnine reduced or blocked the inhibition of the VMH neurons caused by not only FCtx stimulation but also glycine application. The results indicate that the VMH receives both excitatory and inhibitory projections from the FCtx, and the inhibition may be transmitted by glycine.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Ohta M,Oomura Y

doi

10.1016/0361-9230(79)90287-9

subject

Has Abstract

pub_date

1979-03-01 00:00:00

pages

231-8

issue

2

eissn

0361-9230

issn

1873-2747

pii

0361-9230(79)90287-9

journal_volume

4

pub_type

杂志文章
  • Discrete regional analysis of norepinephrine, dopamine, choline acetyltransferase and glutamic acid decarboxylase in the brain of the newborn and pubescent monkey.

    abstract::A method is described for the removal of discrete areas of the monkey brain. A detailed mapping of norepinephrine, dopamine, choline acetyltransferase and glutamic acid decarboxylase in the newborn and pubescent monkey brain is presented. ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(80)80016-5

    authors: Jacobowitz DM,Kato M,O'Neill RR,Speciale SG Jr,Gottesfeld Z,Caveness WF

    更新日期:1980-07-01 00:00:00

  • Actions of epinephrine on neurons in the rat midbrain periaqueductal gray maintained in vitro.

    abstract::The effect of epinephrine (EPI) on the activity of 150 periaqueductal gray (PAG) neurons was examined using extracellular recordings in an in vitro slice preparation. Drop application of EPI inhibited 45%, excited 35%, and had no effect on 20% of PAG neurons. Both the excitatory and inhibitory effects of EPI were of l...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(92)90158-t

    authors: Jiang M,Chandler SD,Ennis M,Shipley MT,Behbehani MM

    更新日期:1992-12-01 00:00:00

  • Chronic psychosocial stress down-regulates central cytokines mRNA.

    abstract::Brain cytokines have been implicated in brain plasticity and mood alterations. We present here the first evidence of a chronic stress-induced modulation of central cytokines, in absence of experimentally induced inflammatory processes. Several brain areas were extracted from stressed and control mice and cytokines mRN...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2003.09.009

    authors: Bartolomucci A,Palanza P,Parmigiani S,Pederzani T,Merlot E,Neveu PJ,Dantzer R

    更新日期:2003-12-30 00:00:00

  • NMDA and non-NMDA receptor antagonists inhibit photic induction of Fos protein in the hamster suprachiasmatic nucleus.

    abstract::We previously reported that systemic treatment with a noncompetitive antagonist affecting the NMDA subtype of excitatory amino acid (EAA) receptor, MK-801, inhibits photic induction of Fos-like immunoreactivity (Fos-lir) in the hamster suprachiasmatic nucleus (SCN). Because MK-801 blocks the Ca2+ channel associated wi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(92)90269-4

    authors: Abe H,Rusak B,Robertson HA

    更新日期:1992-05-01 00:00:00

  • Olfactory bulbectomy increases basal suprachiasmatic cyclic AMP levels in male rats.

    abstract::For further characterization of the olfactory bulb's role in the medication of chronobiological phenomena, we examined basal cyclic- 3',5'-adenosine monophosphate (cAMP) levels in the suprachiasmatic nuclei (SCN) and lateral hippocampus (LHIP) following bilateral olfactory bulbectomy (OBX) to assess the effects of olf...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(91)90219-a

    authors: Vagell ME,McGinnis MY,Possidente BP,Narasimhan VN,Lumia AR

    更新日期:1991-12-01 00:00:00

  • Development of the dopamine-immunoreactive system in the central nervous system of the sea lamprey.

    abstract::The development of dopamine-immunoreactive (DAir) populations in the central nervous system of the sea lamprey, a modern representative of the earliest vertebrates, was studied to achieve further understanding of dopaminergic systems in vertebrates. The first DAir cell groups appeared in the spinal cord, the posterior...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2005.05.004

    authors: Abalo XM,Villar-Cheda B,Anadón R,Rodicio MC

    更新日期:2005-09-15 00:00:00

  • Activity of thermosensitive neurons of monkey preoptic hypothalamus during thermoregulatory operant behavior.

    abstract::Unit activities of thermosensitive (TS) and non-TS neurons in the medial preoptic area (MPO) of the monkey were investigated during a high fixed-ratio (FR 12-30) bar press behavior to seek cool air (CT) in a warm environment. The monkey performed the task when ambient temperature (Ta) was raised (35-43 degrees C) and ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(87)90134-1

    authors: Hori T,Kiyohara T,Oomura Y,Nishino H,Aou S,Fujita I

    更新日期:1987-05-01 00:00:00

  • GABA(A) receptor alpha4 subunit in DBA/2J and C57BL/6J mice.

    abstract::GABA(A) receptors are chloride channels in the brain activated by binding of gamma-aminobutyric acid (GABA). Several important classes of drugs, including alcohol and certain antiepileptic drugs, modulate the actions of GABA. We report the sequence and expression of alpha4 subunits of GABA(A) receptors in two inbred s...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(98)00134-8

    authors: Cestari IN,Liu ZF,Mu W,Burt DR

    更新日期:1998-12-01 00:00:00

  • The role of Nogo-A in neuroregeneration: a review.

    abstract::Nogo, also known as Reticulon-4, is a protein that is specific to the central nervous system (CNS), and has been identified as an inhibitor of neurite outgrowth. Nogo-A is the largest member of the Nogo family and is responsible for inhibition of CNS regeneration. The structural information and biological functions of...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainresbull.2012.02.011

    authors: Wang T,Xiong JQ,Ren XB,Sun W

    更新日期:2012-04-10 00:00:00

  • Is binding to nicotinic acetylcholine and dopamine receptors related to working memory in rats?

    abstract::Nicotinic acetylcholine (ACh) and dopamine (DA) receptor activation has been found to be important for working memory. The regional distribution of these receptors in the brain has been well characterized. However, the relationship of the region-specific nicotinic ACh and DA binding density to memory performance has n...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(97)00009-9

    authors: Levin ED,Torry D,Christopher NC,Yu X,Einstein G,Schwartz-Bloom RD

    更新日期:1997-01-01 00:00:00

  • The role of alpha-2 adrenoceptors in the regulation of oxytocin neurones in the suckled rat.

    abstract::The role of alpha-2 adrenoceptors in the milk-ejection reflex was investigated by making electrophysiological recordings from oxytocin neurones in the supraoptic nucleus of urethane-anaesthetised rats. Systemic administration of the alpha-2 adrenoceptor antagonist. Idazoxan (0.5 mg/kg, i.v.), temporarily suppressed OT...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(97)00115-9

    authors: Bailey A,Clarke G,Wakerley J

    更新日期:1997-01-01 00:00:00

  • Baroreceptor regulation of salt intake.

    abstract::Baroreceptor input plays a critical role in body fluid balance and the endocrine response to NaCl consumption [25]. Experiments were performed to characterize the alterations in salt intake that are seen after baroreceptor denervation. Using chronically baroreceptor denervated (SAD) or control (CON) male Sprague-Dawle...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(96)00234-1

    authors: Rocha MJ,Callahan MF,Morris M

    更新日期:1997-01-01 00:00:00

  • Expression of Fos in the spinal motoneurons labelled by horseradish peroxidase following middle cerebral artery occlusion in rat.

    abstract::The study was aimed at the investigation of the rat corticospinal system both functionally and anatomically using as a functional marker the immediate early gene c-fos, combined with retrograde tracing with horseradish peroxidase (HRP). This was achieved by mapping c-fos induction immunocytochemically in the spinal co...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(97)00451-6

    authors: Wu YP,Ling EA

    更新日期:1998-04-01 00:00:00

  • Raccoon forelimb motorsensory cortex: II. Somatosensory inputs to single neurons.

    abstract::Somatosensory input to 431 neurons in MsI has been studied in unanesthetized, paralyzed raccoons (Procyon lotor). The type of sensory input to neurons in lateral sigmoid gyrus (cytoarchitectonic area 4) and in posterior sigmoid gyrus (areas 4 and 3a) was not significantly different. Of these neurons, 36% were activate...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(90)90146-q

    authors: Gugino LD,Rowinski MJ,Stoney SD Jr

    更新日期:1990-06-01 00:00:00

  • Special issue on 'Cytoskeletal proteins in health and neurodegenerative disease'.

    abstract::The cytoskeleton is the major intracellular structure that determines the morphology of neurons and maintains their structural integrity. It is therefore not surprising that a disturbance of cytoskeletal structure and functionunderlies many neurodegenerative diseases. This special issue brings together current informa...

    journal_title:Brain research bulletin

    pub_type: 社论

    doi:10.1016/j.brainresbull.2016.08.003

    authors: Brandt R,Götz J

    更新日期:2016-09-01 00:00:00

  • Excitatory amino acid transporters in the zebrafish: Letter to "Expression and functional analysis of Na(+)-dependent glutamate transporters from zebrafish brain" from Rico et al.

    abstract::Excitatory amino acid transporters (EAATs) represent a group of high affinity glutamate transporters that are involved in the regulation of extracellular glutamate levels at glutamatergic synapses. EAAT proteins have been found on neurons as well as on glia cells where they act synergistically to remove the released g...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2010.04.018

    authors: Gesemann M,Maurer CM,Neuhauss SC

    更新日期:2010-10-30 00:00:00

  • Anterograde transport of HSV-1 and HSV-2 in the visual system.

    abstract::The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 18...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(92)90038-y

    authors: Norgren RB Jr,McLean JH,Bubel HC,Wander A,Bernstein DI,Lehman MN

    更新日期:1992-03-01 00:00:00

  • Depth amplitude and phase profiles of carbachol-induced theta in hippocampal formation slices.

    abstract::Phase and amplitude depth profiles of EEG theta-like activity (TLA) induced by bath perfusion of 50 micro M of the cholinergic agonist carbachol were investigated using rat hippocampal formation slices. The data showed that the amplitude and phase of laminar profiles of TLA recorded in vitro were the same as the type ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(02)00827-4

    authors: Kowalczyk T,Konopacki J

    更新日期:2002-09-30 00:00:00

  • Progesterone receptor isoforms expression in the prepuberal and adult male rat brain.

    abstract::Progesterone receptor (PR) isoforms expression was determined in several regions of the prepuberal and adult male rat brain by using reverse transcription coupled to polymerase chain reaction. Rats under a 14:10-h light-dark cycle, with lights on at 0600 h were used. We found that in the hypothalamus of prepuberal ani...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(00)00410-x

    authors: Guerra-Araiza C,Reyna-Neyra A,Salazar AM,Cerbón MA,Morimoto S,Camacho-Arroyo I

    更新日期:2001-01-01 00:00:00

  • Cortical evolution and human behaviour.

    abstract::All mammals have complex behaviours but these are generally stereotyped in nature and lack the flexibility of human behaviour. Can the flexibility of human behaviour be understood as an evolutionary extension of previous behaviours or is it a departure? Theories pertaining to this question have a long history includin...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainresbull.2007.06.008

    authors: Neill D

    更新日期:2007-09-28 00:00:00

  • Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos.

    abstract::Developing animals are more sensitive than adults to the delayed neurotoxicity caused by chlorpyrifos exposure. In developing rat brain, chlorpyrifos doses that cause no discernible systemic toxicity and only a minor degree of cholinesterase inhibition, nevertheless evoke alterations in cell function and number that a...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(97)00329-8

    authors: Johnson DE,Seidler FJ,Slotkin TA

    更新日期:1998-01-01 00:00:00

  • Immunohistochemical estimation of rat brain somatostatin on avoidance learning impairment induced by thiamine deficiency.

    abstract::In rats, on the 25th day after the start of a thiamine-deficient (TD) diet, impairment of avoidance learning was significantly induced in proportion to the decrease somatostatin (SST) fluorescence intensity in the cortex, amygdala, thalamus, hypothalamus, and hippocampus, including the CA1, CA2, and dentate gyrus (DG)...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(99)00201-4

    authors: Nakagawasai O,Tadano T,Niijima F,Tan-No K,Kisara K

    更新日期:2000-01-01 00:00:00

  • The activity and expression of aromatase in songbirds.

    abstract::Songbirds have emerged as extremely important animals for investigating sex steroid hormone effects on the central nervous system. The masculinizing effects of exogenous estrogen on the neural circuits controlling song in female zebra finches are well documented. There is evidence that estrogens are necessary for the ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/s0361-9230(97)00215-3

    authors: Schlinger BA

    更新日期:1997-01-01 00:00:00

  • Location of putative glutamatergic neurons projecting to the medial preoptic area of the rat hypothalamus.

    abstract::The medial preoptic area is a key structure in the neural control of reproduction. Considerable evidence has accumulated indicating that glutamatergic innervation of the area plays an important role in this control. Sources of the glutamatergic input are unknown. Present investigations were aimed at studying this ques...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(03)00180-1

    authors: Kocsis K,Kiss J,Csáki A,Halász B

    更新日期:2003-08-30 00:00:00

  • Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats.

    abstract::A reduction in nerve conduction velocity and an increase in resistance to ischemic conduction failure are early signs of neural dysfunction in both diabetic patients and animal models of diabetes. The effect of Bimoclomol (BRLP-42), a drug under clinical development for the treatment of diabetic complications, on expe...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(97)00118-4

    authors: Bíró K,Jednákovits A,Kukorelli T,Hegedüs E,Korányi L

    更新日期:1997-01-01 00:00:00

  • Widespread dopaminergic projections of the subparafascicular thalamic nucleus in the rat.

    abstract::The subparafascicular thalamic nucleus (Spf) contains a substantial number of dopaminergic neurons. The present study was designed to investigate in the rat whether or not Spf neurons projecting to a variety of central nervous system structures are dopaminergic. The following eight structures were tested for projectio...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(93)90191-d

    authors: Takada M

    更新日期:1993-01-01 00:00:00

  • Circadian rhythms differ between selected mouse lines: a model to study the role of vasopressin neurons in the suprachiasmatic nuclei.

    abstract::Mice selected for differences in nest-building behavior differ in the number of arginine-vasopressin (AVP)-immunoreactive neurons in the suprachiasmatic nuclei (SCN). Although previous efforts to link AVP-immunoreactive neurons in the SCN to clock function have failed, we show that differences in several circadian par...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(93)90164-7

    authors: Bult A,Hiestand L,Van der Zee EA,Lynch CB

    更新日期:1993-01-01 00:00:00

  • Atlas of serotonergic cell bodies in the cat brainstem: an immunocytochemical analysis.

    abstract::The localization and relative number of serotonergic (5HT) cell bodies in the brainstem of the cat were studied through the use of a specific immunocytochemical technique. A surprisingly large number of 5HT cells were found in regions in addition to the classical raphe nuclei (obscurus, pallidus, magnus, centralis sup...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(84)90003-0

    authors: Jacobs BL,Gannon PJ,Azmitia EC

    更新日期:1984-07-01 00:00:00

  • Direct connections of primary afferent fibers with spinal neurons projecting to the facial nucleus in the cat.

    abstract::Spinal neurons projecting to the facial nucleus, located in the lateral portion of lamina V from the C1 to C4 segments, had long dendrites extending into lamina IV. The detailed morphology of these spinal neurons was confirmed using the Golgi impregnation method. Dorsal root fibers were distributed mainly to lamina IV...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(87)90155-9

    authors: Takeuchi Y,Takahashi O,Satoda T,Matsushima R

    更新日期:1987-10-01 00:00:00

  • Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin.

    abstract::The central anti-nociception of BmK IT2, a sodium channel modulator from scorpion Buthus martensi Karsh (BmK) was investigated in this study. It was found that the formalin-induced rat spontaneous flinches and spinal c-Fos expression could be significantly suppressed by intrathecal BmK IT2 pre- or post-formalin inject...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2007.03.007

    authors: Bai ZT,Liu T,Pang XY,Chai ZF,Ji YH

    更新日期:2007-07-12 00:00:00