Suppression by intrathecal BmK IT2 on rat spontaneous pain behaviors and spinal c-Fos expression induced by formalin.

Abstract:

:The central anti-nociception of BmK IT2, a sodium channel modulator from scorpion Buthus martensi Karsh (BmK) was investigated in this study. It was found that the formalin-induced rat spontaneous flinches and spinal c-Fos expression could be significantly suppressed by intrathecal BmK IT2 pre- or post-formalin injection in a dose-dependent manner. The time course of inhibitory effect exerted by intrathecal BmK IT2 on spontaneous flinches was longer in the pre-treatment group than in post-treatment group. This was consistent with the stronger suppression on spinal c-Fos expression exerted by intrathecal BmK IT2 pre-treatment. In addition, the suppression by intrathecal BmK IT2 on formalin-induced c-Fos expression in superficial laminae was more significant than that in deeper laminae. These results indicate that BmK IT2 can induce central anti-nociceptive response and might thus be a valuable molecular tool for the understanding of pain mechanisms.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Bai ZT,Liu T,Pang XY,Chai ZF,Ji YH

doi

10.1016/j.brainresbull.2007.03.007

subject

Has Abstract

pub_date

2007-07-12 00:00:00

pages

248-53

issue

4-6

eissn

0361-9230

issn

1873-2747

pii

S0361-9230(07)00101-3

journal_volume

73

pub_type

杂志文章
  • Sex differences in interhemispheric correlation and spectral power of EEG activity.

    abstract::EEG activity was recorded from left and right parietal cortex in adult male and female rats on a daily basis during 3 days. Absolute and relative power and interhemispheric correlation of the EEG activity were calculated and compared between males and females. Interhemispheric correlation of the theta rhythm was highe...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(95)00081-o

    authors: Juárez J,Corsi-Cabrera M

    更新日期:1995-01-01 00:00:00

  • Effects of ovarian hormones on levels of luteinizing hormone in plasma and on serotonin concentrations in discrete brain nuclei.

    abstract::Levels of serotonin were measureed in microdissected, individual brain nuclei in ovariectomized rats after treatment with ovarian hormones. Regions sampled included nuclei in the forebrain, rostral and medial hypothalamus, and midbrain tegmentum. Estradiol benzoate decreased levels of luteinizing hormone in plasma but...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(79)90044-3

    authors: Crowley WR,O'Donohue TL,Muth EA,Jacobowitz DM

    更新日期:1979-07-01 00:00:00

  • Labeling knife cuts: a new method for revealing the functional anatomy of the CNS demonstrated on the noradrenergic dorsal bundle.

    abstract::To assess the efficacy of using an HRP-coated wire knife to label cells of origin of cut axons, labeling cuts were made both through and parallel to the dorsal noradrenergic bundle. The damage to the dorsal bundle was evaluated independently by using fluorescence microscopy to detect the buildup of norepinephrine in c...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(82)90050-8

    authors: Scouten CW,Harley CW,Malsbury CW

    更新日期:1982-02-01 00:00:00

  • The use of place conditioning in studying the neuropharmacology of drug reinforcement.

    abstract::The place conditioning paradigm has proven successful in identifying the neural mechanisms of drug reinforcement. Two classes of drugs, opiates and psychomotor stimulants, have received the most study, and in each case an important role for DA neurons of the mesolimbic system has been established. Moreover, both recep...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(89)90224-4

    authors: Hoffman DC

    更新日期:1989-10-01 00:00:00

  • α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a degenerative disease with a progressive loss of motor neurons in the central nervous system (CNS). However, there are unsolved problems with the therapies for this disease. α-Lipoic acid (LA) is a natural, universal antioxidant capable of scavenging hydroxyl radicals as well as...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2018.05.019

    authors: Wang T,Cheng J,Wang S,Wang X,Jiang H,Yang Y,Wang Y,Zhang C,Liang W,Feng H

    更新日期:2018-06-01 00:00:00

  • 3H-2-deoxyglucose uptake after electrical stimulation of cardioactive sites in insular cortex and mediodorsal nucleus of the thalamus in rabbits.

    abstract::The uptake of 3H-2-deoxyglucose (3H-2-DG) in selected brain structures was determined subsequent to electrical stimulation of insular cortex (Ins) and the mediodorsal (MD) nucleus of the thalamus in rabbits. Stimulation of Ins elicited parasympathetic-like responding (i.e., bradycardia and depressor responses); wherea...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(87)90148-1

    authors: Buchanan SL,Powell DA

    更新日期:1987-10-01 00:00:00

  • Inhibitory effect of regucalcin on Ca(2+)-dependent protein kinase activity in rat brain cytosol: involvement of endogenous regucalcin.

    abstract::The effect of regucalcin, a Ca(2+)-binding protein, on Ca(2+)-dependent protein kinase activity in the brain cytosol of rats with different ages (5 and 50 weeks old) was investigated. The addition of calmodulin (10 microg/ml) or dioctanoylglycerol (5 microg/ml) in the enzyme reaction mixture caused a significant incre...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(99)00184-7

    authors: Hamano T,Hanahisa Y,Yamaguchi M

    更新日期:1999-10-01 00:00:00

  • Factors controlling adrenal weight and corticosterone secretion in male rats as revealed by median eminence lesions and pharmacological alteration of prolactin secretion.

    abstract::To determine whether or not prolactin, as well as ACTH, was involved in the control of adrenal weight and steroid release, lesions in the median eminence which had previously resulted in impaired steroid release and atrophy of the adrenal were placed in animals in which the plasma prolactin was allowed to rise as a re...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(87)90066-9

    authors: Marubayashi U,McCann SM,Antunes-Rodrigues J

    更新日期:1987-11-01 00:00:00

  • Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging.

    abstract::GnRH release from hypothalamic explants from young and aged male Wistar-Kyoto rats was evaluated following stimulation with glutamate receptor agonists. Glutamate stimulated GnRH release to a similar extent in hypothalami from young and old animals, whereas N-methyl-D-Aspartate (NMDA) and kainate appeared more efficac...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(96)00199-2

    authors: Sortino MA,Aleppo G,Scapagnini U,Canonico PL

    更新日期:1996-01-01 00:00:00

  • Response to commentary on evolution of slow-wave sleep and palliopallial connectivity in mammals and birds: a hypothesis.

    abstract::Mammals and birds are the only animals that exhibit high-amplitude slow-waves (SWs) in the electroencephalogram during sleep. The SWs that characterize slow-wave sleep (SWS) in mammals and birds reflect the large-scale synchronization of slow neuronal activity. In mammals, this synchronization is dependent upon the hi...

    journal_title:Brain research bulletin

    pub_type: 评论,杂志文章

    doi:10.1016/j.brainresbull.2007.02.010

    authors: Rattenborg NC

    更新日期:2007-05-30 00:00:00

  • Development of the serotonergic system in the rat embryo: an immunocytochemical study.

    abstract::The development of central serotonergic neurons has been examined immunocytochemically utilizing an antiserum to serotonin (5-HT). Cells of the B4-B9 complex are first detected early on embryonic day 13 (E13; 7 mm crown rump length, CRL) and increase rapidly in number through E15 when they appear as bilateral columns ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(83)90144-2

    authors: Wallace JA,Lauder JM

    更新日期:1983-04-01 00:00:00

  • Sadness as a passion of the soul: a psychopathological consideration of the Cartesian concept of melancholy.

    abstract::The relationship between the "passions" (emotions or feelings) and psychopathology has been a constant throughout the history of medicine. In this context, melancholy was considered a perversion of the soul (corruption of the passions). One of the most influential authors on this subject was René Descartes, who discus...

    journal_title:Brain research bulletin

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.brainresbull.2011.01.018

    authors: López-Muñoz F,Rubio G,Molina JD,Alamo C

    更新日期:2011-04-25 00:00:00

  • lncRNA Mtss1 promotes inflammatory responses and secondary brain injury after intracerebral hemorrhage by targeting miR-709 in mice.

    abstract::Secondary brain injuries following intracerebral hemorrhage (ICH) are mediated by inflammatory pathway activation. The present study aimed to characterize long noncoding RNAs (lncRNAs) that are differentially expressed in cerebral tissues during ICH pathogenesis and to investigate their pathogenic functions. An ICH mo...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2020.04.017

    authors: Chen JX,Wang YP,Zhang X,Li GX,Zheng K,Duan CZ

    更新日期:2020-09-01 00:00:00

  • Effects of chronic reserpine treatment on development of maturity of the putamen in fetal rabbits.

    abstract::Developing nigrostriatal axons and their perikarya have substantial quantities of dopamine (DA) before the axons reach their postsynaptic target. In order to investigate possible developmental effects of these stores of DA, we have depleted DA chronically during critical periods in the ontogeny of the nigrostriatal sy...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(82)90169-1

    authors: Tennyson VM,Budininkas-Schoenebeck M,Gershon P

    更新日期:1982-07-01 00:00:00

  • Suppression of inflammation by dexamethasone prolongs adenoviral vector-mediated transgene expression in the facial nucleus of the rat.

    abstract::Adenoviral vector directed gene transfer to rat facial motoneurons occurs efficiently following intra-parenchymal injection of relatively high dosages (> or =10(7) pfu per injection) of a prototype first generation adenoviral vector. However, high level of transgene expression, as observed during the first week follow...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(98)00042-2

    authors: Hermens WT,Verhaagen J

    更新日期:1998-09-15 00:00:00

  • Behavioural and hormonal effects of restraint stress and formalin test in male and female rats.

    abstract::The formalin test was used to measure the analgesia induced by restraint in male and female rats. Animals were restrained for 30 min or left undisturbed in their cage and then (1) killed immediately to collect blood for hormonal determinations; or (2) subcutaneously injected with formalin in the hind paw (or sham-inje...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(98)00063-x

    authors: Aloisi AM,Ceccarelli I,Lupo C

    更新日期:1998-09-01 00:00:00

  • The distribution of substance P in the cerebral cortex and hippocampal formation: an immunohistochemical study in the monkey and rat.

    abstract::The distribution of substance P-containing fibers in the cerebral cortex and the hippocampal formation of the Japanese monkey (Macaca fuscata fuscata) was studied by immunohistochemistry using a monoclonal antibody raised against substance P. The results were compared with the distribution in homologous regions of the...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(89)90057-9

    authors: Iritani S,Fujii M,Satoh K

    更新日期:1989-02-01 00:00:00

  • Evidence for hemispheric specialization in the marmoset (Callithrix penicillata) based on lateralization of behavioral/neurochemical correlations.

    abstract::A correlative study between behavioral, neurochemical and hormonal measures was conducted on male black tufted-ear marmoset monkeys (Callithrix penicillata). Behavioral analysis was performed in order to examine the effects of confrontation with a natural predator (taxidermized oncilla cat, Felis tigrina). The subject...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2007.07.012

    authors: Silva MA,Topic B,Lamounier-Zepter V,Huston JP,Tomaz C,Barros M

    更新日期:2007-11-01 00:00:00

  • The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function.

    abstract::Locomotor performance of transgenic R6/2 mice carrying the Huntington's disease (HD) mutation was assessed using four different tasks, fixed speed rotarod, accelerating rotarod, Digigait and footprint test. The tasks were compared directly in age- and CAG repeat-matched R6/2 mice. Accelerating rotarod was more sensiti...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2008.10.007

    authors: Pallier PN,Drew CJ,Morton AJ

    更新日期:2009-03-30 00:00:00

  • Effects of L- and D-enantiomers of N omega-nitro-arginine on NMDA-evoked striatal dopamine overflow.

    abstract::The microdialysis method was utilized to study the effects of N omega-nitro-L-arginine (L-NNA) and N omega-nitro-D-arginine (D-NNA), an inhibitor of nitric oxide (NO) synthesis from L-arginine and its D-enantiomer, on spontaneous and N-methyl-D-aspartate (NMDA)-evoked overflow of striatal extracellular dopamine (DA) i...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(94)90021-3

    authors: Ishida Y,Yamamoto R,Mitsuyama Y

    更新日期:1994-01-01 00:00:00

  • Association of dopaminergic terminals and neurons releasing nitric oxide in the rat striatum: an electron microscopic study using NADPH-diaphorase histochemistry and tyrosine hydroxylase immunohistochemistry.

    abstract::To examine synaptic input and association of terminals containing dopamine and other transmitters to rat striatal nitric oxide synthase-expressing neurons, an electron microscopic study using tyrosine hydroxylase (TH) immunohistochemistry combined with histochemistry for NADPH-diaphorase (NADPHd) was performed. NADPHd...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(96)00035-4

    authors: Fujiyama F,Masuko S

    更新日期:1996-01-01 00:00:00

  • The response of central glia to peripheral nerve injury.

    abstract::Microglial and astroglial cells undergo prompt responses to peripheral motor and sensory axon injury. These responses include proliferation of microglial cells as well as hypertrophy and increased levels of glial fibrillary acidic protein around the axotomized motoneurons and in the central projection territories of p...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/0361-9230(93)90284-i

    authors: Svensson M,Eriksson P,Persson JK,Molander C,Arvidsson J,Aldskogius H

    更新日期:1993-01-01 00:00:00

  • Monkey pyramidal tract neurons and changes of movement parameters in visual tracking.

    abstract::During a single-step visual tracking task of monkeys, parametric changes of the wrist extension-flexion movement and related discharge rate changes of pyramidal tract neurons (PTNs) of hand-arm motor area were studied. The task consisted of preparatory, precontraction, contraction and target periods. If the displaceme...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(79)90289-2

    authors: Hamada I,Kubota K

    更新日期:1979-03-01 00:00:00

  • Immunohistochemical and chromatographic identification of peptides derived from proneuropeptide Y in the human frontal cortex.

    abstract::Proneuropeptide Y (proNPY) is posttranslationally processed to NPY(1-36)amide and the C-terminal flanking peptide of NPY (CPON). Antisera directed against the N-terminal part of NPY, CPON, or CysNPY(32-36)amide were used to identify peptide fragments processed from proNPY in biopsies of human frontal cortical specimen...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(93)90235-4

    authors: Mikkelsen JD,Larsen PJ,Kruse-Larsen C,O'Hare MM,Schwartz TW

    更新日期:1993-01-01 00:00:00

  • Altered conditioned taste aversion and glucose utilization in related brain nuclei of diabetic GK rats.

    abstract::The impact of diabetes and especially hyperglycemia on brain glucose utilization and insulin binding are still not clear. This is probably due to the fact that most studies have been performed in streptozotocin treated rats that are highly hyperglycemia and that could have an effect per se on the brain. The aim of the...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(95)00060-r

    authors: Marfaing-Jallat P,Portha B,Pénicaud L

    更新日期:1995-01-01 00:00:00

  • Enhancing effects of binary mixtures of acid with salt on the gustatory neural activity in the clawed toad, Xenopus laevis.

    abstract::Binary mixtures of acid with salt were observed to produce enhancing effects on oral chemoreceptor responses by recording the activity of the whole glossopharyngeal nerve of the clawed toad (Xenopus laevis). The mixtures of HCl with various inorganic salts elicited responses larger than the sum of the responses to ind...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(96)00326-7

    authors: Yamashita S,Hisadome K,Yotsumata Y,Kiyohara S

    更新日期:1997-01-01 00:00:00

  • The history of the Golgi apparatus in neurones from its discovery in 1898 to electron microscopy.

    abstract::We celebrate in 1998 the centenary of the discovery of the Golgi apparatus. Neurones have played a special role in the history of this cell organelle, primarily because the endocellular apparatus was discovered in nerve cells by Camillo Golgi when he was studying the cerebellum of an owl. In the following years, the a...

    journal_title:Brain research bulletin

    pub_type: 传,历史文章,杂志文章,评审

    doi:10.1016/s0361-9230(98)00080-x

    authors: Dröscher A

    更新日期:1998-10-01 00:00:00

  • Electrophysiological correlates among the radial nerve, the caudate and the entopeduncular nuclei in cats.

    abstract::The entopeduncular nucleus (EPN), as the medial part of the globus pallidum, has been considered the efferent structure of the striatum. Based on this, we decided to study its possible somatosensory projections and the electrophysiological relationship with the caudate nucleus (CN). Radial nerve stimulation produced e...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(81)80050-0

    authors: Saavedra de Camargo B,Brust-Carmona H,Roig JA

    更新日期:1981-03-01 00:00:00

  • Isolation of glomeruli from areas of bovine cerebellum and comparison of [3H]serotonin uptake.

    abstract::A method for bulk preparation of glomerular particles from subdivisions of the bovine cerebellum is presented. This method represents a modification of that previously reported by Hajos et al. [8], which increases the yield of glomerular protein by five-fold (5.5 mg/g wet wt) without compromising structural integrity ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(85)90025-5

    authors: Terrian DM,Butcher WI,Wu PH,Armstrong DL

    更新日期:1985-05-01 00:00:00

  • The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression.

    abstract::Flinders Sensitive Line (FSL) rat is as an animal model of depression with altered parameters of the serotonergic (5-HT) system function (5-HT synthesis rates, tissue concentrations, release, receptor density and affinity), as well as an altered sensitivity of these parameters to different 5-HT based antidepressants. ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2012.04.009

    authors: Skelin I,Kovačević T,Sato H,Diksic M

    更新日期:2012-08-01 00:00:00