Abstract:
:The effect of epinephrine (EPI) on the activity of 150 periaqueductal gray (PAG) neurons was examined using extracellular recordings in an in vitro slice preparation. Drop application of EPI inhibited 45%, excited 35%, and had no effect on 20% of PAG neurons. Both the excitatory and inhibitory effects of EPI were of long duration; excitatory responses averaged 17 min and inhibitory responses averaged 11 min in duration. EPI responses could be blocked by specific alpha-1 and alpha-2 receptor antagonists. In 35% of the neurons tested, blockade of synaptic transmission by perfusion with low calcium-high magnesium physiological saline blocked responses to EPI. The effects of EPI were site specific: 77% of the cells in the caudal ventrolateral region of the PAG were inhibited by EPI; in all other regions of PAG equal numbers of cells were excited and inhibited by EPI. It is concluded that: (a) EPI has potent effects on a majority (80%) of PAG neurons; (b) EPI responses are mediated by presynaptic as well as postsynaptic mechanisms; (c) EPI preferentially inhibits neurons in the ventrolateral subdivision of caudal PAG. As this part of PAG contains many neurons that project to the ventral medulla, it is possible that EPI modulates the PAG-medullary functions such as analgesia, autonomic regulation, defense reactions, and sexual behaviors.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Jiang M,Chandler SD,Ennis M,Shipley MT,Behbehani MMdoi
10.1016/0361-9230(92)90158-tkeywords:
subject
Has Abstractpub_date
1992-12-01 00:00:00pages
871-7issue
6eissn
0361-9230issn
1873-2747pii
0361-9230(92)90158-Tjournal_volume
29pub_type
杂志文章abstract::Calcitonin, a peptide hormone expressed in C-cells of the thyreoid gland, as well as capsaicin, isolated from chili, both, modify intracellular signalling in nociceptive neurones. The pathways triggered by the activation of either of these receptors results in a modulation of the intracellular calcium ([Ca(2+)](i)) co...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2011.02.006
更新日期:2011-04-25 00:00:00
abstract::In the central nervous system cell migration is usually restricted to developmental periods and occurs mainly radially, following the radial glia. Nevertheless, in the subependymal layer of the adult rodent forebrain tangential migration of newly generated neuronal precursors directed to the olfactory bulb, which foll...
journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(81)90111-8
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(87)90079-7
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:2007-04-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:2017-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90083-3
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0361-9230(94)90142-2
更新日期:1994-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2010.04.016
更新日期:2010-07-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2004.07.006
更新日期:2004-09-30 00:00:00
abstract::Methylphenidate (MPD) is currently one of the most prescribed drug therapies for attention deficit/hyperactivity disorder (ADHD) and moreover is abused for cognitive enhancement and used for recreation by the young and adults. Methylphenidate is used for prolonged periods of time and its mechanism of action on the bra...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2011.10.008
更新日期:2012-03-10 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2006-12-11 00:00:00
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pub_type: 杂志文章
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更新日期:2002-10-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2009.03.003
更新日期:2009-06-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(96)00227-4
更新日期:1996-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(77)90079-x
更新日期:1977-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90223-5
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:2012-04-10 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2002-01-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.05.015
更新日期:2005-09-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90095-9
更新日期:1984-09-01 00:00:00
abstract::Previously obtained data suggests that noradrenaline (NE) released from the efferent locus coeruleus (LC) endings in hippocampal formation (HPC) may serve as an important modulating signal involved in the pharmacological mechanisms responsible for the production of type 2 theta rhythm in rats. Hence, two distinct hypo...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.05.017
更新日期:2020-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2006-03-31 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90149-1
更新日期:1983-04-01 00:00:00
abstract::To investigate the direct actions of neurotropin (NSP, a nonproteinaceous extract from inflamed skin of rabbits which is in therapeutic use), intracellular recordings were made from neurons of the ventromedial hypothalamic nucleus (VMH) and lateral hypothalamic area (LHA) in slices of guinea pig brain. In the VMH, NSP...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90144-m
更新日期:1992-12-01 00:00:00
abstract::Groups of male Sprague-Dawley rats were predominantly fed either a high-fat or a high-carbohydrate (CHO) diet. For designated 2-day periods, their diets were switched. After baseline measurements of food and water intake, the rats were made diabetic by injections of either 40 or 46-50 mg/kg streptozotocin. Food and wa...
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pub_type: 杂志文章
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更新日期:1986-12-01 00:00:00